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anti-Mouse (Murine) Integrin beta 7 Antibodies:
anti-Human Integrin beta 7 Antibodies:
anti-Rat (Rattus) Integrin beta 7 Antibodies:
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Baboon Monoclonal Integrin beta 7 Primary Antibody for FACS - ABIN262944
Yoshino, Ami, Terao, Tashiro, Honda: Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. in Experimental animals / Japanese Association for Laboratory Animal Science 2000
Show all 6 Pubmed References
Human Monoclonal Integrin beta 7 Primary Antibody for FACS - ABIN2689794
Butcher, Picker: Lymphocyte homing and homeostasis. in Science (New York, N.Y.) 1996
Show all 4 Pubmed References
Mouse (Murine) Monoclonal Integrin beta 7 Primary Antibody for CyTOF, FACS - ABIN4899531
Richard, Roy, Audoy-Rémus, Tremblay, Vallières: Crawling phagocytes recruited in the brain vasculature after pertussis toxin exposure through IL6, ICAM1 and ITGαM. in Brain pathology (Zurich, Switzerland) 2011
AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.
beta7 integrin, when expressed by hematopoietic stem cells (HSC (show FUT1 Antibodies)), interacted with its endothelial ligand MAdCAM-1 (show MADCAM1 Antibodies) in the Bone marrow microenvironment, thereby promoting HSC (show FUT1 Antibodies) homing and engraftment.
CCR9 (show CCR9 Antibodies) and Integrin-beta7 expression has a differential effect on graft fate during acute graft-versus-host disease (GVHD) of the liver depending on the GVHD target tissue.
The E-cadherin (show CDH1 Antibodies) beta-7 integrin pathway probably controls migration of enterocytes within the small intestinal surface lining epithelial layer.
KLF3 (show KLF3 Antibodies) acts as transcriptional repressor for the leukocyte-specific integrin beta7 (Itgb7, Ly69) by binding to the beta7 promoter, as revealed by chromatin immunoprecipitation.
Mice lacking beta7 integrins in the innate immune compartment are more susceptible to intestinal inflammation, which is correlated with a requirement of beta7 integrins to reconstitute gut (show GUSB Antibodies) mononuclear phagocytes with tolerogenic potential.
E-cadherin (show CDH1 Antibodies) and alpha(E)beta(7) integrin on dendritic epidermal T cells regulate their activation threshold through binding to E-cadherin (show CDH1 Antibodies) on keratinocytes
lack of alpha4beta7 or E-selectin (show SELE Antibodies) significantly reduced trafficking of CD4 (show CD4 Antibodies) T cells to the GT of mice infected with C. muridarum.
results suggest the importance of alphaEbeta7 expression by TGF-beta (show TGFB1 Antibodies) in selective localization of intestinal intraepithelial T lymphocytes
The induction of alpha4beta7 following activation of mouse cells with the APC (show APC Antibodies)-dependent stimulus soluble anti-CD3 (show CD3E Antibodies) has been examined. (alpha4beta7 integrin)
gut (show GUSB Antibodies)-homing alpha4beta7 CD4 (show CD4 Antibodies)(+) T cells and their functional subsets were profoundly depleted during acute HIV-1 infection.
Collectively, these data suggest a role for alpha4beta7 integrin in HIV infection that is influenced by both viral and host factors including the sequence of the HIV gp120 (show ITIH4 Antibodies) alpha4beta7 binding motif, the cytokine milieu and bacterial vaginosis in the genital tract.
circulating trisomy 12 CLL cells also have increased expression of the integrins CD11b (show ITGAM Antibodies), CD18 (show ITGB2 Antibodies), CD29 (show ITGB1 Antibodies), and ITGB7, and the adhesion molecule (show NCAM1 Antibodies) CD323.
Disruption of the hydrophobic contacts induces the active conformation of integrin alpha 4 (show ITGA4 Antibodies) beta 7.
Only rotavirus specific CD4 (show CD4 Antibodies) T cells expressed intestinal homing receptors alpha4beta7 and CCR9 (show CCR9 Antibodies).
Data indicate that signaling by HIV-1 gp120 (show ITIH4 Antibodies) through integrin alpha4beta7 resulted in increased expression of the immunosuppressive cytokine TGF-beta1 (show TGFB1 Antibodies) and FcRL4 (show FCRL4 Antibodies).
Integrin alpha4beta7 binds gp120 (show ITIH4 Antibodies) but does not mediate HIV envelope-induced death signaling.
Consistent with structural predictions, strain increases beta-integrin binding to FLNA (show FLNA Antibodies), whereas it causes FilGAP (show ARHGAP24 Antibodies) to dissociate from FLNA (show FLNA Antibodies), providing a direct and specific molecular basis for cellular mechanotransduction
mediates adhesion to mucosal addressin cell adhesion molecule-1 (MAdCAM-1)
M290 IEL antigen
, integrin beta-7
, integrin beta-P
, gut homing receptor beta subunit
, integrin beta 7 subunit