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ITGA4 is an important integrin in the molecular pathogenesis of gastrointestinal stromal tumours and may influence their clinical behaviour.
Increased frequencies of pre-HIV alpha4beta7(+) CD4(+) T cells were also associated with higher postinfection expression of lipopolysaccharide binding protein, a microbial translocation marker, suggestive of more extensive gut damage.
our data link for the first time NOTCH1 mutations to CD49d expression regulation through the involvement of the NF-kappaB pathway in CLL.
defines molecularly distinct subsets of articular cartilage that are enriched for osteochondral proteins
study suggests a novel association of ITGA4 +3061A/G polymorphism with AD and its possible contribution to the disease pathology.
The results of this study demonstrated that aggregation of hWJSCs into spherules alters their expression of ITGA4 and ITGA5.
human ADAM11, ADAM23, and ADAM29 selectively support integrin alpha4-dependent cell adhesion.
Recombinant human IL33 inhibited trophoblast invasion and adhesion, and decreased adhesion and invasionassociated molecules such as integrin alpha4beta1 and CD62L.
study analyzes for the first time the expressions of epithelial-mesenchymal transition marker proteins - periostin, integrin alpha4, fibronectin - in metastatic castration-resistant prostate cancer
ITGalpha4beta1 and TLR4 have roles in inducing fibrotic gene expression in response to fibronectin's EDA domain
ITGA4 and PLCG1 are regulated by miR-30b in coronary artery endothelial cells from coronary atherosclerosis clinical samples.
Low CD49D expression is associated with chronic lymphocytic leukaemia in comparison to small lymphocytic lymphoma.
alpha-Integrin expression and function modulates presentation of cell surface calreticulin.
AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.
sPLA2-IIA activates Integrin alphaVbeta3 and Integrin alpha4beta1 in an allosteric manner. (Review)
Our results suggest that the analysis of alpha4beta7 integrin expression on circulating lymphocytes cannot be considered a reliable test for gastrointestinal involvement in CVID patients
Glycosylation of V1V2 domain of HIV envelope protein determined its binding to alpha4ss7 integrin.
confirmed CD49d as an independent negative OS prognosticator in CLL also in comprehensive models comprising the novel recurrent mutations.
In colon cancer samples, there was a positive correlation between the expression of integrin alpha4 and VEGF-C. Integrin alpha4 and VEGF-C were significantly associated with the clinicopathological parameters (LMVD, Duke's stage, and lymph node metastasis). patients with high integrin alpha4 or VEGF-C expression had significantly shorter overall survival and tumor-free survival time.
Macrophage tissue factor prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking.
inhibition of FAK activity may reduce VCAM-1 expression within lymph nodes and thus reduce metastasis of alpha4 integrin-expressing melanoma to lymph nodes.
results establish ROS-elicited glutathionylation and its modulation by Grx1 as pivotal regulatory mechanisms controlling alpha4 integrin affinity and neutrophil mobilization from the bone marrow under physiological conditions.
the data suggest that CXCR3 and the integrin alpha4 mediate T cell recruitment to uninfected salivary glands but that redundant mechanisms mediate T cell recruitment after Murine Cytomegalovirus infection.
As blockade of PI3Kgamma or integrin alpha4 prevents accumulation of myeloid-derived suppressor cells and reduces myeloid cell expression of immunosuppressive factors that stimulate tumor immune escape, these results highlight PI3Kgamma and integrin alpha4 as targets for the design of cancer therapeutics.
integrin alpha4beta1 mediates the inhibitory effect of oncofetal Fibronectin both in vitro as well as in vivo.
investigation of the role of alpha4 integrin and the therapeutic effect of HCA3551, a newly synthesized orally active small molecule alpha4 integrin antagonist, in the development of Theiler's murine encephalomyelitis virus-induced demyelinating disease
Here we delineated an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity that required direct adhesive interactions between macrophages and adipocytes mediated by the integrin alpha4 and its counter-receptor VCAM-1, respectively; expression of the latter was upregulated in obesity.
uncovered the importance of Itga4 for the generation of regulatory B cells in peripheral immune organs and their control of pathogenic T cell response and CNS pathology
this study shows that alpha4beta1 integrin mediates memory CD8+ T cells accumulation in salivary glands after infection with lymphocytic choriomeningitis virus
The results uncovered a previously unknown role of integrin a4b7-MAdCAM-1 interactions as drivers of colitis by directing inflammatory monocytes into the colon.
Integrin a4b7 is essential for suppression of experimental colitis as it regulates the colonic Treg cell population and innate immunity.
These results suggest that Tie2 signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1.
ITGA4 expression enhances metastasis in MYCN low neuroblastoma.
investigated which alpha4beta1-integrin ligands expressed by endothelial cells are implicated
Data indicate a role of integrin alpha4beta7 (alpha4beta7) in diet-induced atherosclerosis.
CD49d-high-expressing Th1 memory phenotype CD4+ T cells with enhanced B cell helper activity develop early in the peritoneal cavity.
Data suggest that bortezomib mobilizes hematopoietic stem cells (HSPCs) by modulation of the integrin alpha4beta1 (VLA)-4/vascular cell adhesion molecule-1 (VCAM-1) axis.
Consistent with a role of alpha4beta7 in the generation of intestinal mononuclear phagocytes, bone marrow cells from beta7(-/-) mice poorly reconstituted small intestine retinoic acid (RA)-producing CD11c(hi) dendritic cells.
Administration of a novel recombinant antibody against alpha4beta7 gut-homing integrin during acute lentiviral infection prevents mobilization of cell lineages of the innate immune system and protects the gut tissues from acute lentiviral infection.
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
269C wild type
, CD49 antigen-like family member D
, VLA-4 subunit alpha
, antigen CD49D, alpha-4 subunit of VLA-4 receptor
, integrin alpha 4
, integrin alpha-4
, integrin alpha-4 subunit
, integrin alpha-IV
, very late activation protein 4 receptor, alpha 4 subunit
, LPAM subunit alpha
, VLA-4 receptor, alpha 4 subunit
, lymphocyte Peyer patch adhesion molecules subunit alpha