Browse our anti-ITGA5 (ITGA5) Antibodies

Mouse (Murine) Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5) interaction partners

1. The Ang1/Tie2 system cross-talks with integrin alpha5beta1 in brain endothelial cells after cerebral ischemia.

2. A dual-specific MCSF antagonist of c-FMS and integrin alpha5beta3 prevents the progression of osteoporosis.

3. integrin alpha 5 (ITGA5) as one key functional miR-205 target in the re-epithelialization process and epidermal downregulation of miR-205 may desilence ITGA5 to promote keratinocyte migration.

4. kindlin-2 interactions with alphaVbeta3 and its other binding partners promote endothelial cell functions potentially relevant to angiogenesis

5. Data suggest that WISP1-alphavbeta3 integrin signaling is involved in Toll-Like Receptor 4 (TLR4) pathways in macrophages.

6. loss of alpha5 integrin-mediated fibrillogenesis interferes with the normal cytoskeleton organization that facilitates epithelial cysts polarization.

7. The findings provide insights into how integrin alphaVbeta3 acts as a molecular machine and how its physiological function and molecular structure are coupled at the single-molecule level.

8. results suggest that Edil3 may stimulate osteoblast differentiation and matrix mineralization by increasing expression of Runx2 through alpha5beta1 integrin /ERK pathway

9. KCNB1 and integrin alpha chain V (integrin-alpha5) coimmunoprecipitated in the mouse brain and these interactions were retained upon channel's oxidation.

10. We demonstrate that AnkB binds to Rab GTPase Activating Protein 1-Like (RabGAP1L) and recruits it to PI3P-positive organelles, where RabGAP1L inactivates Rab22A, and promotes polarized trafficking to the leading edge of migrating fibroblasts. We further determine that a5b1-integrin depends on an AnkB/RabGAP1L complex for polarized recycling

11. Osteoprotegerin facilitates pulmonary arterial hypertension pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation via integrin alphavbeta3/FAK/AKT signaling pathway.

12. endothelial cell alpha5 integrin plays an important role in stroke outcome and blood-brain barrier integrity

13. FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner.

14. cells on fibronectin suppressed cAMP via enhanced phosphodiesterase (PDE) activity, through direct binding of integrin alpha5 to phosphodiesterase-4D5

15. this study shows that protective effect of osteopontin results from integrin-alpha5-dependent enhancement of neutrophil migration and accumulation at sites of infection

16. The present study has revealed an integrin- and membrane lipid raft-dependent mechanotransduction mechanism by which atheroprone flow causes endothelial dysfunction.

17. Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 induced the expression of the alphaV sub-unit.

18. EGFR activation can be regulated by the N-glycosylation of integrin alpha5, which is a novel molecular paradigm for the cross-talk between integrins and growth factor receptors

19. Integrin alpha5beta1 and its FN ligand played critical roles not only in single-cell line adhesion, but also in adhesion between stem and niche cells.

20. An (as yet unknown) integrin alpha5-dependent signal extrinsic to the pharyngeal endothelium mediates the formation of the 4th pharyngeal arch arteries through fibronectin.

Human Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5) interaction partners

1. Results found that Integrin-a5 modulates the autophagy that mediates the cell aggregation and survival of breast cancer cells.

2. Results show that interleukin-6 (IL-6) and integrin alphavbeta6 (integrin alphanubeta6) are indicators of cancer progression and poor prognosis in patients with colon cancer.

3. EGFL7 expression promoted glioma growth in experimental glioma models in vivo and stimulated tumor vascularization. Mechanistically, this was mediated by an upregulation of integrin alpha5beta1 on the cellular surface of endothelial cells, which enhanced fibronectin-induced angiogenic sprouting.

4. Integrin alpha5beta6 down-regulation causes a significant increase in donor cancer cells, and their exosomes, of two molecules that have a tumor suppressive role, STAT1 and MX1.

5. Helicobacter pylori binding to alpha5beta1 integrin under shear flow is dependent on the CagY, but independent of the presence of the T4SS pili, which are only formed when H. pylori is in contact with host cells.

6. The results of this study demonstrated that aggregation of hWJSCs into spherules alters their expression of ITGA4 and ITGA5.

7. The results showed that in cervical cancer cells Rac1 activation by hypoxia could stimulate invasion and migration, and this process was mediated by integrin a5b3-facilitated FAK and PI3K phosphorylation.

8. A specific component of the gastric refluxate, deoxycholic acid, affects the epithelial barrier through modulation of integrin alpha V expression, providing a novel mechanism for bile acid-mediated erosion of esophageal squamous epithelium and promotion of Barrett's Esophagus.

9. first PET/CT scans of head and neck squamous cell carcinoma (HNSCC) and NSCLC patients displayed SFITGv6 accumulation specifically in tumors, but not in inflammatory lesions.Thus, SFITGv6 represents a novel powerful tracer for imaging and possibly for endoradiotherapy of ITGa5b6-positive carcinoma

10. Endothelial cell-derived matrix promotes the metabolic functional maturation of hepatocyte via integrin-Src signaling.

11. N-glycosylation controlled the EGFR complex formation with integrin alpha5beta1 or alpha6beta4

12. integrin alpha5 might be involved in Aggregatibacter actinomycetemcomitans Y4 invasion into gingival epithelial cells, and the resulting signal transduction cascade reduces cell adhesion by decreasing the expression of integrins, while the TLR2/4 signaling cascade regulates IL-8 expression.

13. Fibronectin fragments (FNFr) function as matrikines driving the chemotactic affinity of prostate cancer cells via the alpha5beta1 integrin.

14. Gene function analyses in in-vitro cultured adipose tissue stem cells (ASCs) indicated differential functions of integrin-alpha-5 (ITGA5) and integrin-alpha-V (ITGAV).

15. Hypoxia induces the expression of ITGA5 in breast cancer.ITGA5 plays role in the breast cancer metastasis.

16. miR-330-5p could suppress proliferation and invasion of glioblastoma cells through targeting ITGA5.

17. Inhibiting Fgf-R partly reversed alphavbeta3 integrin activity in Mll-Ell+ progenitor cells.

18. Thus, Aspergillus fumigatus CalA is an invasin that interacts with integrin alpha5beta1 on host cells, induces endocytosis and enhances virulence.

19. Data map the network of interactions between host-cell alpha5beta1 integrin and the cagT4SS proteins.

20. Data indicate integrinalphavbeta3 is a tumor target on breast cancer bone metastases.

Cow (Bovine) Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5) interaction partners

1. Putative function of fibronectin and its receptor (integrin alpha(5)beta(1)) in male and female gametes during bovine fertilization in vitro.

2. Results indicate that XIAP stabilizes the alpha(5)-integrin-associated focal adhesion complex, thereby further regulating endothelial cell adhesion and migration.

3. alphavbeta3 integrin engagement in vascular endothelium regulates Ca2+-dependent K+ current

4. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.