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CrkL Antigen Profile
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
Alternative names and synonyms associated with CrkL
CRK like proto-oncogene, adaptor protein (CRKL) ELISA Kit