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Findings unveil a negative role for PKC-delta in cell-cell adhesion through phosphorylation of E-cadherin (show CDH1 Proteins).
ADP inhibits mesothelioma cell proliferation via PKC-delta/JNK (show MAPK8 Proteins)/p21 (show CDKN1A Proteins)/p27 (show PAK2 Proteins) signaling.
PKCdelta, via MAPK (show MAPK1 Proteins) pathway, is involved in the glycodelin (show PAEP Proteins)-driven cell differentiation.
PKCdelta is a critical regulator of signaling mechanisms of neutrophil-endothelium interaction in acute inflammation. Inhibition of PKCdelta in human endothelial cells and neutrophils reduced chemoattractant-induced neutrophil migration across TNF-alpha (show TNF Proteins)-activated endothelium, and reduced expression of E-selectin (show SELE Proteins) and ICAM-1 (show ICAM1 Proteins). Shear rate and vascular geometry regulate the impact of PKCdelta inhibition of neutrophil-endot...
Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck (show HCK Proteins)-dependent activation of PKCdelta, which stimulates PKCgamma (show PRKCG Proteins), resulting in translocation of phosphorylated p47(phox).
The interplay between intracellular progesterone receptor (show PGR Proteins) and PRKCA (show PKCa Proteins)-PRKCD plays a key role in migration and invasion of human glioblastoma cells.
Amphiregulin (show AREG Proteins) enhances VEGF-A (show VEGFA Proteins) production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR (show MLXIP Proteins)-206 via FAK (show PTK2 Proteins)/c-Src (show SRC Proteins)/PKCdelta pathway.
In the present investigation, we demonstrated that miR486 is negatively associated with the expression of PKC-delta and could regulate the development of osteosarcoma. miR (show MLXIP Proteins)-486 may be a potential target for the treatment of osteosarcoma
PKCdelta and PKCepsilon (show PRKCE Proteins) work as a functional couple with opposite roles on thrombopoiesis, and the modulation of their balance strongly impacts platelet production.
These findings suggest that targeting Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) or Akt (show AKT1 Proteins) pathways may increase the efficacy of taxane chemotherapy in advanced human prostate cancers that have lost PKCdelta expression.
Our key findings provide novel insights into the mechanism of action of heterotrimeric complex (PKCdelta-TIRAP (show TIRAP Proteins)-p38 (show CRK Proteins)) in proinflammatory cytokine expression, which controls the development of the inflammatory trigger in stimulated macrophages.
sustained PKCdelta activation drives sustained microglial inflammatory responses and concomitant dopaminergic neurotoxicity consequently leading to neurobehavioral deficits
spinal PKCdelta has a role in the development of chronic pain in SCD (show SCD Proteins), which may become a potential target for pharmacological interventions
K8/K18 (show KRT18 Proteins)-dependent PKCdelta- and ASMase (show SMPD1 Proteins)-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (show KRT18 Proteins) loss.
MALAT1 recruits splice factor serine-arginine-rich splice factor 2 (SRSF2 (show SRSF2 Proteins)) to promote alternative splicing of PKCdeltaII.
SphK1 (show SPHK1 Proteins) dependent PKC-delta activation plays an important role in promoting NF-kappaB (show NFKB1 Proteins) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta activation might be a potential therapeutic strategy for this disease.
PKCdelta activity exerts a dual role through the autophagy mechanism, decreasing proliferative capacity of mammary tumor cells but also regulating tumor stem cell self-renewal.
alpha(1)-AR activation is anti-apoptotic and protective during cardiac ischemia due to glucose deprivation and not hypoxia by enhancing glucose uptake into the heart via PKCdelta-mediated GLUT (show SLC1A3 Proteins) translocation that may be specific to the alpha(1A)-AR subtype.
Study shows that PRKCD influences corticotroph cell viability, POMC (show POMC Proteins) and ACTH (show POMC Proteins) expression suggesting that PRKCD plays an important role in restraining corticotroph cell proliferation and function.
PKCdelta-mediated phosphorylation of 14-3-3zeta (show YWHAZ Proteins) contributes to the nuclear retention of FOXO1 (show FOXO1 Proteins), even when FOXO1 (show FOXO1 Proteins) is phosphorylated as under non-stress conditions
Report PRKCD-dependent regulation of bovine embryonic development, gene expression and post-hatching events.
investigation of signaling mechanism used by fibroblast growth factor-2 (FGF2 (show FGF2 Proteins)) to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 (show FGF2 Proteins) regulates IFNT production in trophoblasts by acting through PRKCD
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS (show NOS3 Proteins) post-translational modification
stimulation of bovine theca cells with lysophosphatidic acid leads to redistribution of protein kinase C delta from the cytosol to the perinuclear area and in the presence of LH, complete nuclear translocation of protein kinase C delta is induced
Protein kinase (show CDK7 Proteins) Cdelta-dependent phosphorylation of syndecan-4 (show SDC4 Proteins) regulates cell migration.
Activation of PKC induces the translocation of Nrf2 (show NFE2L2 Proteins) and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
PKC-delta (show PRKCG Proteins) mediates the apoptotic processes through ROS (show ROS1 Proteins)-dependent caspase-3 (show CASP3 Proteins) activation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
protein kinase C delta VIII
, protein kinase C delta type
, tyrosine-protein kinase PRKCD
, protein kinase C delta variant IX
, protein kinase C, delta IV
, protein kinase C, delta V
, protein kinase C[d]
, protein kinase-delta2
, protein kinase C, delta
, protein kinase C delta type-like
, protein kinase C delta