-
CARM1 methylates PKM2 at arginines 445 and 447, which enhances PKM2 tetramer formation. Consequently, Carm1 knockout cells exhibit significant survival advantages over WT cells when extracellular serine is limited, likely due to their enhanced de novo serine synthesis capacity. Altogether, we identified CARM1 as an important regulator of glucose metabolism and serine synthesis.
-
CARM1 gene expression was repressed by p53 in 3T3L1 preadipocytes when activated with Nutlin-3a treatment. Ectopic CARM1 overexpression could rescue inhibitory effect of p53 on adipogenesis. p53 and CARM1 showed antagonistic regulatory influence on PPAR-gamma expression. p53-mediated suppression of adipogenesis could be partly via repression of CARM1 expression.
-
Study shows that peripheral nerve injury induced the upregulation of the mRNA and protein expression of coactivator-associated arginine methyltransferase 1 (CARM1) in the injured dorsal root ganglion. Findings suggest that CARM1 may serve as a promising therapeutic target for neuropathic pain treatment in clinical applications.
-
PRMT activity is selectively augmented during the initial activation of exercise-induced skeletal muscle remodeling in vivo.
-
C9orf72 acts by promoting the lysosomal degradation of coactivator-associated arginine methyltransferase 1 (CARM1), which in turn regulates autophagy-lysosomal functions and lipid metabolism.
-
the present study increases our understanding of PRMT1, -4, and -5 biology during the plasticity of skeletal muscle development. Our results provide evidence for a role of PRMT1, via a mitochondrially mediated mechanism, in driving the muscle differentiation program.
-
Study describes peptide-based transition state mimics that form stable complexes with CARM1 resulting in high-resolution co-crystal structures. The findings provide an exciting approach to understanding protein arginine methyltransferase (PRMT) substrate recognition and the regulation of arginine methylation.
-
CARM1 promotes EZH2-mediated silencing of EZH2/BAF155 target tumor suppressor genes by methylating BAF155.
-
These observations demonstrate that oxidative stress destabilizes PRMT4 via GSK-3beta signaling to impede lung epithelial cell migration that may hinder the lung repair and regeneration process.
-
AMPK deficiency results in nuclear CARM1 decrease mediated in part by SKP2, contributing to autophagy dysfunction in the aged heart.
-
Study identifies CARM1, which methylates histone H3 at arginine 26 (H3R26), as an upstream regulator of Sox21 expression. These results indicate that heterogeneity in gene expression patterns biases cell fate in the mouse embryo as early as the 4-cell stage.
-
findings demonstrate that CARM1-dependent histone arginine methylation is a crucial nuclear event in autophagy, and identify a new signalling axis of AMPK-SKP2-CARM1 in the regulation of autophagy induction after nutrient starvation
-
CARM1 haploinsufficiency impairs transdifferentiation and wound healing in a mouse model.
-
PRMT4 might be a key regulator of high-glucose-induced insulin secretion from pancreatic beta cells via H3R17 methylation.
-
Data show that the methyltransferase CARM1 (coactivator-associated arginine methyltransferase 1; PRMT4) methylated Notch intracellular domain (NICD) at five conserved arginine residues.
-
we identify BAF155 as a substrate for arginine methyltransferase CARM1.
-
Arginine methylation of Pax7 by Carm1 functions as a molecular switch controlling the epigenetic induction of Myf5 during satellite stem cell asymmetric division and entry into the myogenic program.
-
CARM1 is a key epigenetic regulator of hematopoiesis that affects multiple lineages at various stages of differentiation.
-
our study provides evidence for a role of CARM1-mediated arginine methylation in regulation of histone acetylation and transcription.
-
PRMT4 is necessary for selective control of a specific gene expression program associated with glycogen metabolism.
