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anti-Human CARM1 Antibodies:
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Human Polyclonal CARM1 Primary Antibody for ICC, IF - ABIN152377
Harrison, Tang, Dowhan: Protein arginine methyltransferase 6 regulates multiple aspects of gene expression. in Nucleic acids research 2010
Show all 6 Pubmed References
Human Monoclonal CARM1 Primary Antibody for ICC, FACS - ABIN969002
Fauquier, Duboé, Joré, Trouche, Vandel: Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
Show all 3 Pubmed References
Human Polyclonal CARM1 Primary Antibody for IF (p), IHC (p) - ABIN763061
Wang, Cui, Wen, Guo, Zhang, Chen: Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway. in Oncology letters 2017
Human Polyclonal CARM1 Primary Antibody for WB - ABIN4287938
Herrmann, Pably, Eckerich, Bedford, Fackelmayer: Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family. in Journal of cell science 2009
Human Polyclonal CARM1 Primary Antibody for WB - ABIN2668761
Mann, Cortez, Vadlamudi: PELP1 oncogenic functions involve CARM1 regulation. in Carcinogenesis 2013
N-terminal EVH1 domain of CARM1 is necessary and sufficient for substrate recognition and is required for methylation of most CARM1 substrates.
SKP2 promotes HCC (show FAM126A Antibodies) progression and its nuclear functions of autophagy induction with CARM1 and AMPK (show PRKAA1 Antibodies), which may provide a potential target for HCC (show FAM126A Antibodies) therapy.
The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3beta/beta-Catenin (show CTNNB1 Antibodies)/cyclinD1 Signaling Pathway
The CARM1-PKM2 axis serves as a metabolic reprogramming mechanism in tumorigenesis.
Arginine (di)methylated human leukocyte antigen class I peptides, which are asymmetrically dimethylated, most likely by CARM1, are favorably presented by HLA-B*07.
Estrogen receptor (show ESR1 Antibodies) recruits steroid receptor coactivator (show SRA1 Antibodies)-3 primary coactivator and secondary coactivators, p300/CBP (show CREBBP Antibodies) and CARM1 to regulate genetic transcription.
Arginine methylation of MDH1 (show MDH1 Antibodies) by CARM1 regulates cellular redox homeostasis and suppresses glutamine (show GFPT1 Antibodies) metabolism of pancreatic cancer.
Here, the crystal structures of human CARM1 with the S-adenosylmethione (SAM (show TTN Antibodies)) mimic sinefungin and three different peptide sequences from histone H3 (show HIST3H3 Antibodies) and PABP1 (show PABPC1 Antibodies) are presented, with both nonmethylated and singly methylated arginine residues exemplified.
CARM1 associates with major nonsense-mediated mRNA decay factor UPF1 (show UPF1 Antibodies) and promotes its occupancy on premature terminating codon-containing transcripts in spinal muscular atrophy.
Monitoring of the CARM1-dependent production of monomethylated and dimethylated peptides over time by self-assembled monolayer and matrix-assisted laser desorption ionization mass spectrometry revealed that methylation by CARM1 is distributive.
C9orf72 (show C9ORF72 Antibodies) acts by promoting the lysosomal degradation of coactivator-associated arginine methyltransferase 1 (CARM1), which in turn regulates autophagy-lysosomal functions and lipid metabolism.
the present study increases our understanding of PRMT1 (show PRMT1 Antibodies), -4, and -5 biology during the plasticity of skeletal muscle development. Our results provide evidence for a role of PRMT1 (show PRMT1 Antibodies), via a mitochondrially mediated mechanism, in driving the muscle differentiation program.
Study describes peptide-based transition state mimics that form stable complexes with CARM1 resulting in high-resolution co-crystal structures. The findings provide an exciting approach to understanding protein arginine methyltransferase (PRMT) substrate recognition and the regulation of arginine methylation.
CARM1 promotes EZH2 (show EZH2 Antibodies)-mediated silencing of EZH2 (show EZH2 Antibodies)/BAF155 (show SMARCC1 Antibodies) target tumor suppressor genes by methylating BAF155 (show SMARCC1 Antibodies).
These observations demonstrate that oxidative stress destabilizes PRMT4 via GSK-3beta signaling to impede lung epithelial cell migration that may hinder the lung repair and regeneration process.
AMPK deficiency results in nuclear CARM1 decrease mediated in part by SKP2, contributing to autophagy dysfunction in the aged heart.
Study identifies CARM1, which methylates histone H3 (show HIST3H3 Antibodies) at arginine 26 (H3R26), as an upstream regulator of Sox21 (show SOX21 Antibodies) expression. These results indicate that heterogeneity in gene expression patterns biases cell fate in the mouse embryo as early as the 4-cell stage.
findings demonstrate that CARM1-dependent histone arginine methylation is a crucial nuclear event in autophagy, and identify a new signalling axis of AMPK (show PRKAA1 Antibodies)-SKP2-CARM1 in the regulation of autophagy induction after nutrient starvation
CARM1 haploinsufficiency impairs transdifferentiation and wound healing in a mouse model.
PRMT4 might be a key regulator of high-glucose-induced insulin (show INS Antibodies) secretion from pancreatic beta cells via H3R17 methylation.
a combinatorial role of PRMT4/CARM1 and PRMT5 (show PRMT5 Antibodies) for proper myogenesis in zebrafish
Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002
histone-arginine methyltransferase CARM1
, protein arginine N-methyltransferase 4
, coactivator-associated arginine methyltransferase 1
, protein arginine methyltransferase