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anti-Human DAB2 Antibodies:
anti-Mouse (Murine) DAB2 Antibodies:
anti-Rat (Rattus) DAB2 Antibodies:
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Mouse (Murine) Polyclonal DAB2 Primary Antibody for WB - ABIN1881248
Collaco, Jakab, Hegan, Mooseker, Ameen: Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine. in The Journal of biological chemistry 2010
Show all 5 Pubmed References
DAB2 is a frequent target of epigenetic silencing in oral carcinomas and may be potentially used for tumor detection
Dab2 Ser723 phosphorylation is a key molecular event in thrombin (show F2 Antibodies)-stimulated inside-out signaling and platelet activation, contributing to a new function of Dab2 in thrombin (show F2 Antibodies) signaling.
DAB2 might be involved in excessive aldosterone biosynthesis and correlate with specific clinical characteristics of aldosterone-producing adenoma patients.
the results indicated that substrate stiffness could regulate EMT (show ITK Antibodies) of cervical cancer cell lines HeLa and SiHa at least partially through miR (show MLXIP Antibodies)-106b and its downstream target DAB2.
DAB2 can suppress the ERK (show EPHB2 Antibodies) signaling, but correlate to have TGF-beta (show TGFB1 Antibodies)-induced epithelial-to-mesenchymal transition (EMT (show ITK Antibodies)) in esophageal squamous cell carcinomas (ESCCs).
The various novel mechanisms are described by which Dab2 mediates an array of signaling events with vast physiological consequences.
In conclusion, DAB2 and Intelectin-1 (show ITLN1 Antibodies) are newly identified positive markers of mesothelioma and have potential to be included in future immunohistochemical marker panels for differentiation of epithelioid mesothelioma from pulmonary adenocarcinoma
cathepsin B (CTSB (show CTSB Antibodies)) inhibition or expression of a CTSB (show CTSB Antibodies)-resistant Dab2 mutant maintains Dab2 expression and shifts long-term TGF-beta (show TGFB1 Antibodies)-treated cells from autophagy to apoptosis
abundances of megalin (show LRP2 Antibodies) and Dab2 (p = 0.046) were reduced in infected placentas from women with LBW deliveries
Data show that miR106b was frequently up-regulated in human cervical carcinoma tumors and cell lines and inversely correlated with DAB2 expression. Its regulation in under TGF-beta1 (show TGFB1 Antibodies) which contributes to cell migration by targeting DAB2 in cervical carcinoma.
miR149 was able to target Dab2 and promote the cardiac differentiation of mouse MSCs in vitro, which depended upon the Wnt/betacatenin signaling pathway.
Dab2 functions as a negative immune regulator of TLR4 (show TLR4 Antibodies) endocytosis and signaling; it has a role in the regulatory circuit in controlling the inflammatory response of macrophages to endotoxin
The results suggest that Dab2 is required for the excessive calorie-induced differentiation of an adipocyte progenitor cell population that is present in juvenile but depleted in mature animals. The finding provides evidence for a limited pre-adipocyte population in juvenile mammals and the requirement of Dab2 in the regulation of Ras/MAPK (show MAPK1 Antibodies) signal in the commitment of the precursor cells to adipose tissues.
The combination of Arh (show LDLRAP1 Antibodies) and Dab2 is responsible for the majority of adaptor function in LDLR (show LDLR Antibodies) endocytosis and LDLR (show LDLR Antibodies)-mediated cholesterol homeostasis.
Results identified a novel activation marker, DAB2, which expression is significantly different between microglia activation stages M2a and either M1 or M2b.
these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages
Dab2 expression is induced by hormones
Results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in multiple sclerosis
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Antibodies) and PTGS2 (show PTGS2 Antibodies), and decreased the expression of SOD2 (show SOD2 Antibodies), GPX3 (show GPX3 Antibodies), DAB2, and NR3C1 (show NR3C1 Antibodies). TNF (show TNF Antibodies) and IL6 (show IL6 Antibodies) levels were also decreased while those of NAMPT (show NAMPT Antibodies) were unaffected.
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
, disabled homolog 2
, disabled homolog 2, mitogen-responsive phosphoprotein
, disabled homolog 2-like
, differentially-expressed protein 2
, mitogen-responsive phosphoprotein
, DOC-2 p82 isoform
, disabled homolog 2 mitogen-responsive phosphoprotein