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Cow (Bovine) Polyclonal FHL2 Primary Antibody for IHC, WB - ABIN2775839
Lee, Chung, Kang: Combined treatment of high pressure and heat on killing spores of Alicyclobacillus acidoterrestris in apple juice concentrate. in Journal of food protection 2006
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Human Polyclonal FHL2 Primary Antibody for ICC, IF - ABIN4311636
Li, Ponten, dos Remedios: The interactome of LIM domain proteins: the contributions of LIM domain proteins to heart failure and heart development. in Proteomics 2012
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Human Polyclonal FHL2 Primary Antibody for ICC, IF - ABIN4311635
Pontén, Gry, Fagerberg, Lundberg, Asplund, Berglund, Oksvold, Björling, Hober, Kampf, Navani, Nilsson, Ottosson, Persson, Wernérus, Wester, Uhlén: A global view of protein expression in human cells, tissues, and organs. in Molecular systems biology 2009
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Human Monoclonal FHL2 Primary Antibody for IHC (fro), IF - ABIN2192004
Samson, Smyth, Janetzky, Wendler, Müller, Schüle, von der Mark, von der Mark, Wixler: The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor. in The Journal of biological chemistry 2004
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Human Polyclonal FHL2 Primary Antibody for ELISA, WB - ABIN268526
Morgan, Madgwick: Slim defines a novel family of LIM-proteins expressed in skeletal muscle. in Biochemical and biophysical research communications 1996
FHL2 is an important prognostic factor in cervical cancer (CC) and that it plays a crucial oncoprotein role by promoting cell proliferation and inhibiting apoptosis in CC.
FHL2 and iASPP (show PPP1R13L Antibodies) interacted with each other and co-localized in both nucleus and cytoplasm. Either FHL2 or iASPP (show PPP1R13L Antibodies) silenced could reduce cell proliferation, induce cell cycle arrest at G0/G1 phase, and increase cell apoptosis.
FHL2 phosphorylation by FAK (show PTK2 Antibodies) is a critical, mechanically dependent step in signaling from soft matrices to the nucleus to inhibit cell proliferation by increasing p21 (show CDKN1A Antibodies) expression.
FHL2 facilitates ovarian granulosa cell tumor progression via controlling AKT1 (show AKT1 Antibodies) transcription.
we determined the molecular mechanism responsible for IER3 (show IER3 Antibodies) degradation, involving a ternary complex of IER3 (show IER3 Antibodies), MDM2 (show MDM2 Antibodies) and FHL2, which may contribute to cervical tumor growth. Furthermore, we demonstrated that FHL2 serves as a scaffold for E3 ligase and its substrate during the ubiquitination reaction, a function that has not been previously reported for this protein
FHL2 interacts with ADAM-17 (show ADAM17 Antibodies) in normal, dysplastic and malignant colon epithelial cells. Colocalisation of these proteins is more frequent in malignant than in normal and dysplastic cells, suggesting a role for ADAM-17 (show ADAM17 Antibodies)/FHL2 complex in the development of colorectal cancer.
FHL2 overexpression could enhance the differentiation and mineralization of human dental pulp cells
findings show that mAbp1 (show DBNL Antibodies) and FHL2 are novel binding partners that differentially regulate Rho GTPase (show RACGAP1 Antibodies) signaling and MTLn3 breast cancer cell invasion
These results identify FHL2 as a novel gene associated with asthma severity in human.
FHL2 might interact with Runx2 (show RUNX2 Antibodies) to mediate mesenchymal cell differentiation at the early stages of tooth development and human dental pulp cell differentiation.
Fhl2 anticipates the emerging inflammation and specifically the development of psoriatic arthritis by impeding the Adam17 (show ADAM17 Antibodies)-mediated release of TNF (show TNF Antibodies)
Loss of FHL2 is associated with liver fibrosis.
loss of Fhl2 leads to an altered immune response to myocardial ischemia, which results in smaller infarcts and better hemodynamic performance up to 21 days after myocardial ischemia reperfusion.
also found that phosphorylation of ERK1/2 is markedly attenuated in FHL2-KO lung
Overexpression of FHL2 alone had no effect on Erbin (show ERBB2IP Antibodies) expression, but in the presence of MITF (show MITF Antibodies), Erbin (show ERBB2IP Antibodies) expression was decreased.
these data identify a previously unrecognized role for FHL2 in the pathogenesis of pulmonary granulomatous inflammation
we conclude that FHL2 has both structural and functional protein-protein interactions with b-catenin in the podocyte nucleus and that FHL2 protein inhibition can mitigate Wnt/b-catenin-induced podocytopathy.
FHL2 serves as a protective factor and that, rather than promoting the pathology, the upregulation of FHL2 in RA occurs in frame of a regenerative attempt.
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified.
LIM domain protein DRAL
, aging-associated gene 11
, down-regulated in rhabdomyosarcoma LIM protein
, four and a half LIM domains protein 2
, skeletal muscle LIM-protein 3
, SLIM 3
, four and a half LIM domains 2
, four and half LIM domains protein 2