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NCOA4 acts as a regulator of DNA replication origins that helps prevent inappropriate DNA synthesis and replication stress.
The H-ferritin could bind up to 24 NCOA4(383-522) fragments forming highly stable and insoluble complexes. The binding was partially inhibited only by Fe(II) among the various divalent metal ions analyzed. The iron-dependent, highly-specific formation of the remarkably stable H-ferritin-NCOA4 complex shown in this work may be important for the characterization of the mechanism of ferritinophagy.
the ATG5 (show ATG5 Proteins)-ATG7 (show ATG7 Proteins)-NCOA4 autophagic pathway has a role in ferroptosis
Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.
Studies indicate nuclear receptor coactivator 4 (NcoA4) as a coactivator for a variety of nuclear receptors.
provide a new mechanism for selective autophagy of ferritin (show FTL Proteins) and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo
RET (show RET Proteins)/PTC3 gene rearrangements are the most prevalent form of rearrangements in papillary thyroid carcinomas of Chennai population.
identification of NCOA4 as a selective cargo receptor for autophagic turnover of ferritin (show FTL Proteins) (ferritinophagy), which is critical for iron homeostasis, and provides a resource for further dissection of autophagosomal cargo-receptor connectivity
mechanism dissection shows that KLK2 (show KLK2 Proteins) may cooperate with the AR coregulator, ARA70, to enhance AR transactivation that may result in alteration of prostate cancer formation
Data indicate that the increase in prostate cancer (PC) risk associated with rs10993994:C>T is likely mediated by the variant's effect of MSMB (show MSMB Proteins)-encoded protein PSP94 (show MSMB Proteins) expression; however, this effect does not extend to NCOA4 in the data.
These studies demonstrate the importance of ferritin (show FTL Proteins) for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 (show PCBP1 Proteins) and NCOA4 in mediating iron flux through ferritin (show FTL Proteins).
NCOA4 prevents iron accumulation and ensures efficient erythropoiesis, playing a central role in balancing iron levels in vivo.
Results demonstrate ubiquitous NcoA4 expression throughout development and suggest that this coactivator may play a role in modulating nuclear receptor activity, particularly that of the aryl hydrocarbon receptor (show AHR Proteins), during development.
Data suggest that myostatin (show MSTN Proteins) decreases the activity of androgen receptors (AR) by down-regulating the expression of ARA70, a known stimulating co-factor of AR
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.
nuclear receptor coactivator 4
, Nuclear receptor coactivator 4
, 70 kDa AR-activator
, 70 kDa androgen receptor coactivator
, RET-activating gene ELE1
, androgen receptor-associated protein of 70 kDa
, ret fused