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PRIP deficiency impairs osteoclast differentiation, particularly at the early stages, and PRIP stimulates osteoclast differentiation through calcium-calcineurin-NFATc1 signaling via regulating intracellular Ca(2+)
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The results suggest that NCOA6 stimulates insulin secretion, at least partially, by modulating Nampt expression in pancreatic beta-cells.
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These results indicate that PRIP is implicated in BMP-induced osteoblast differentiation by the negative regulation of Smad phosphorylation, through the methylation of inhibitory Smad6.
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The results indicate that PRIP negatively regulates UCP1-mediated thermogenesis in brown adipocytes.
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Two independent mouse models of NCOA6 dysfunction develop severe dilated cardiomyopathy with impaired mitochondrial function and reduced activity of peroxisome proliferator-activated receptor delta.
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The NCOA6 controls E(2) sensitivity and uterine receptivity by regulating multiple E(2)-signaling components.
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ASC-2 negatively affects hepatic insulin sensitivity, at least in part, through induction of the insulin signalling inhibitors SOCS1 and SOCS3.
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PRIP is implicated in the negative regulation of bone formation
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diverse physiological function of NCOA6 may be mediated by multiple isoforms expressed in different tissues and localized in different subcellular compartments
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methylation of transporter promoters by MLL3 as part of activating signal cointegrator-2 -containing complex is essential for activation of bile salt export pump
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The apoptotic-like processes in the transgenic lens were both p53-dependent and p53-independent. Lens-specific deletion of Ncoa6 also resulted in disrupted lens fiber cell differentiation.
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These results suggest that AIB3 is required for PPARgamma function in placental development and for normal heart development.
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role as modulator of placental, cardiac, hepatic, and embryonic development
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Our results demonstrate that RAP250 is necessary for placental development and thus essential for embryonic development
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AIB3 mRNA and protein are preferentially expressed in specific cell types, suggesting that AIB3 may support the function of nuclear receptors in a cell type-specific manner.
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PRIP, like PPARgamma-binding protein, is a downstream regulator of PPARgamma-mediated adipogenesis and that both these coactivators are required for the successful completion of adipogenic program
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peroxisome proliferator-activated receptor-interacting protein (PRIP)is important for normal mammary gland development
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Overexpressed ASC-2 increased glucose-elicited insulin secretion, whereas insulin secretion was decreased in islets from ASC-2+/- mice.
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Results show that PRIP is not essential for nuclear translocation of constitutive androstane receptor.
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Results suggest that ASC-2 confers target gene specificity to MLL3 and MLL4 H3K4MT complexes and that recruitment of H3K4MTs to their target genes involves interactions between integral components of H3K4MT complexes and transcription factors.