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NODAL/Activin signaling induces dramatic chromatin landscape changes, and a dynamic transcriptional network regulated by SMAD2 (show SMAD2 Proteins), acting via multiple mechanisms.
these results therefore highlight an unanticipated role for p53 (show TP53 Proteins) family proteins in a regulatory network that integrates essential Wnt (show WNT2 Proteins)-Tcf (show HNF4A Proteins) and nodal-Smad (show SMAD1 Proteins) inputs.
In the presence of a Nodal heterozygous mutation mice lacking both Tgif1 (show TGIF1 Proteins) and its paralog, Tgif2 (show TGIF2 Proteins), survive to late gestation.
PGAP6 plays a critical role in Nodal signaling modulation through CRIPTO (show TDGF1 Proteins) shedding.
results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty (show LEFTY2 Proteins)-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (show DNMT3A Proteins) and DNMT3B (show DNMT3B Proteins); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (show HELLS Proteins) and demethylation crucial to regulation of key signalling pathways in early body plan formation
Results indicate that microRNA miR (show MLXIP Proteins)-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2 (show LEFTY2 Proteins)).
The finding that Foxh1 (show FOXH1 Proteins)-Grg (show AES Proteins)-mediated repression is not essential for Nodal expression during mouse embryogenesis suggests that other regulators compensate for the loss of repressive regulatory input that is mediated by Grg (show AES Proteins) interactions.
The Nodal morphogen (show SHH Proteins) gradient induces distinct gene expression patterns during zebrafish embryogenesis.
HEB is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells
Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2 (show LEFTY2 Proteins)) has a conserved role in left-right asymmetry.
cancer cells lack the presence of Lefty (show LEFTY2 Proteins), thus leading to uncontrolled tumor growth. Given this understanding, inhibition of the Nodal pathway offers a new novel therapeutic target in oncology
Nodal signaling through the Smad2 (show SMAD2 Proteins)/3 pathway up-regulated Slug, Snail (show SNAI1 Proteins) and c-Myc (show MYC Proteins) to induce EMT (show ITK Proteins), thereby promoting Vasculogenic mimicry (VM) formation.
n this work, we report two patients with a DAND5 (show DAND5 Proteins) heterozygous non-synonymous variant (c.455G > A) in the functional domain of the DAND5 (show DAND5 Proteins) protein (p.R152H), a master regulator of Nodal signaling. Patient 1 presents left isomerism, ventricular septal defect with overriding aorta and pulmonary atresia, while patient 2 presents ventricular septal defect with overriding aorta, right ventricular hypertrophy
Together SMAD3 (show SMAD3 Proteins) and ZIC2 (show ZIC2 Proteins) regulate FOXA2 (show FOXA2 Proteins) transcription in cultured cells and Zic2 (show ZIC2 Proteins) also controls the foxA2 (show FOXA2 Proteins) expression during Xenopus development. These findings reveal a new mechanism of NODAL signal transduction in the mammalian node and provide the first molecular explanation of how ZIC2 (show ZIC2 Proteins) loss-of-function precipitates Holoprosencephaly (HPE
Data show that BRAF (show BRAF Proteins) inhibitor (BRAFi) treatment failed to affect Nodal protein levels in melanoma tissues.
Oct-4 (show POU5F1 Proteins) signaling is modulated by nodal via nuclear translocation of beta-catenin (show CTNNB1 Proteins) in lung and prostate cancer cells
patients with tumors in which both Nodal and YAP1 (show YAP1 Proteins) were expressed at high levels had the worst prognosis
The MSX2 controls mesendoderm lineage commitment by simultaneous suppression of SOX2 (show SOX2 Proteins) and induction of NODAL expression through direct binding and activation of the Nodal promoter.
During a maturation phase, a fast acting NODAL loop stimulates its own activity and temporarily inhibits BMP signaling. During the stabilization phase, a slow acting NODAL loop, involving WNTs re-establishes BMP signaling and the pluripotency circuitry.
FoxH1 (show FOXH1 Proteins) and Grg4 occupy the Xnr1 enhancer, and Grg4 occupancy is dependent on the FoxH1 (show FOXH1 Proteins) EH1 (show EPHX1 Proteins) motif. Grg4 occupancy at the Xnr1 enhancer significantly decreases with Nodal activation or Smad2 (show SMAD2 Proteins) overexpression, while FoxH1 (show FOXH1 Proteins) occupancy is unaffected. These results suggest that Nodal-activated Smad2 (show SMAD2 Proteins) physically displaces Grg4 from FoxH1 (show FOXH1 Proteins), an essential feature of the transcriptional switch mechanism.
Data show taht combined Wnt (show WNT2 Proteins) and Nodal signaling synergistically activates transcription of Spemann organizer genes.
Data suggest that Coco (show DAND5 Proteins) acts as a critical target of flow, suggesting that symmetry is broken by flow-mediated left-asymmetric release of Nodal repression at the midline.
Data show that rapid differential transport of Nodal and Lefty (show LEFTY2 Proteins) on sulfated (show SULF1 Proteins) proteoglycan (show Vcan Proteins)-rich extracellular matrix regulates left-right asymmetry in Xenopus.
Unilateral expression of Xnr-1 in the left lateral plate mesoderm directs the orientation of the left-right axis by driving the left-specific gene cascade.
asymmetric expression of Nodal-related 1 (Xnr1) begins in the posterior left lateral plate mesoderm shortly after the initiation of bilateral perinotochordal expression in the posterior tailbud
Xnr1 and derriere (show GDF3 Proteins) are coexpressed in the posterior paraxial mesoderm at neurula stage, and with Coco (show DAND5 Proteins) define a posttranscriptionally regulated signaling center in the chain leading to an increased TGF-beta (show TGFB1 Proteins) signal on the left side of the embryo.
The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development.
nodal-related protein 1
, nodal homolog (mouse)
, nodal homolog
, Nodal protein
, nodal homolog-like
, early embryo mesoderm formation
, transgenic lethal 413.d
, Nodal homolog 4
, nodal homolog 4-A
, nodal-related protein 4-A
, nodal-related 1, induction of axial mesoderm