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anti-Human POU4F2 Antibodies:
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Cow (Bovine) Polyclonal POU4F2 Primary Antibody for WB - ABIN2780610
Samady, Faulkes, Budhram-Mahadeo, Ndisang, Potter, Brabant, Latchman: The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells. in International journal of cancer. Journal international du cancer 2006
Show all 2 Pubmed References
DNA methylation in a combination of POU4F2/PCDH17 has yielded the highest sensitivity and specificity of 90.00% and 93.96% in all the 312 individuals, showing the capability of detecting bladder cancer effectively among pathologically varied sample groups.
The genes BCL6, NFE2, POU4F2 and ELF4 are primary 1,25(OH)2D3 targets in THP-1 cells
Methylation levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 in urine specimens are promising diagnostic biomarkers for bladder cancer recurrence surveillance
Levels of CDK4 mRNA and protein correlate with levels of Brn-3b in breast cancer cell lines manipulated to express different levels of Brn-3b and in human breast cancer biopsies; Brn-3b can activate the CDK4 promoter
Brn-3b transcription factor contributes to proliferation of neuroblastoma cells in vivo and in vitro but may also influence progression and/or invasion during tumorigenesis.
Brn-3b can, directly and indirectly (via interaction with the ER), activate HSP-27 expression, and this may represent one mechanism by which Brn-3b mediates its effects in breast cancer cells.
Brn-3b expression has been shown to be a prerequisite for developmental survival of most retinal ganglion cells.
first time that a Brn-3b POU family transcription factor has been shown to regulate a member of the catenin family, which provides insight into the molecular mechanisms by which Brn-3b expression may favour breast cancer progression and tumor invasion
Two different microRNAs that potentially regulate the stability of Brn-3b have been identified in neuroblastoma cells.
May act to alter growth properties of breast cancer and neuroblastoma cells by enhancing cyclin D1 expression in these tumor cells.
Brn3b specifies the RGC fate from multipotential precursors not only by promoting RGC differentiation but also by suppressing non-RGC differentiation programs as a safeguard mechanism.
Double morphant embryos targeted with morpholino oligonucleotides to both TFs develop significant cardiac defects (looping abnormalities and valve defects) suggesting essential roles for Brn-3a and Brn-3b in developing hearts.
Dlx1 and Dlx2 function both downstream of ATOH7 and in parallel, but cooperative, pathways that involve regulation of Brn3b expression to determine retinal ganglion cell fate.
he present Pou4f2-GFP knock-in mouse line is a useful tool for further studies on the differentiation and regeneration of retinal ganglion cells
Strongylocentrotus purpuratus Pou4f1/2 and mouse Pou4f2 share conserved components of a gene network for photosensory development and they maintain their conserved intrinsic functions despite vast morphological differences in mouse and sea urchin photosensory structures.
Dynamic expression of Brn3b was identified in the somatosensory component of cranial nerves during different stages of development.
transient expression ofFezf2in the retina modulates the transcription ofBrn3band the survival of RGCs.
Pou4f2 KO mice exhibit profound hyperglycemia, increased GSK3B expression, and decreased GLUT4 expression. In C2C12 myocytes, Pou4f2 mRNA and protein are induced by glucose and inhibited by insulin.
Results suggest the existence of a coordinated mechanism by miR-23a and miR-374 to down regulate Brn3b and ultimately regulate the development of retinal ganglion cells from their precursors
Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate in ATOH7 deficient mice
Increased Brn-3b and p53 correlated with elevated expression of pro-apoptotic target genes, Bax, Noxa and PUMA, whereas cleaved caspase-3 confirmed the presence of apoptotic cells within this region of the injured heart.
Study demonstrates a sequential expression order of NEUROD1>ISL1>POU4F1>POU4F2 during the inner ear neurogenesis.
Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice.
Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells.
Data indicate that Brn3 transcription factors Brn3b affects Brn3a and Brn3c positive Retinal Ganglion Cells (RGCs) in cell autonomous and non-cell autonomous fashion.
Brn3b is expressed in a subset of intrinsically photosensitive retinal ganglion cells
Brn-3b suppresses the role of DLX1/2 through physical interaction and biases the competent precursors toward retinal ganglion cell fates.
Generalized retinal ganglion cell and combined nerve fiber layer and inner plixiform layer loss was observed in Brn3b(-/-) retinas
Brn3b regulates gene expression through the action of a strong transcriptional activation domain within its N-terminal sequence.
Eomes is a crucial regulator positioned immediately downstream of Pou4f2 and is required for retinal ganglion cell differentiation and optic nerve development.
Math5 and Brn3b double null mice exhibit over a 99% reduction in the number of retinal ganglion cells during development.
The cloning and expression profile of brn-3b in the zebrafish (Danio rerio) were assessed as the first step for understanding its role in the development of sensory systems.
member of the POU family of transcription factors\\\\; play key roles in the development of specific neuronal cell types
Brn3b POU domain transcription factor
, POU domain class 4 transcription factor 2
, POU domain protein
, POU domain, class 4, transcription factor 2
, brain-specific homeobox/POU domain protein 3B
, POU domain, class 4, transcription factor, related sequence 1
, POU class 4 homeobox 2
, POU-homeodomain protein