SAFB Proteins

Protein Summary

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SAFB

• scaffold attachment factor B (SAFB) antibody
• scaffold attachment factor B (Safb) antibody
• scaffold attachment factor B (safb) antibody
• scaffold attachment factor B S homeolog (safb.S) antibody
• SAFB-like transcription modulator (LOC5570070) antibody
• Show all gene names
• scaffold attachment factor B (CpipJ_CPIJ017179) antibody
• Scaffold attachment factor B (Bm1_49330) antibody
• scaffold attachment factor B (LOAG_00080) antibody

• 3110021E02Rik antibody
• 5330423C17Rik antibody
• AU018122 antibody
• D18386 antibody
• E130307D12 antibody
• Show all synonym aliases
• HAP antibody
• HET antibody
• SAF-B1 antibody
• SAFB antibody
• SAFB1 antibody
• SAFB2 antibody
• wu:fb40a03 antibody
• wu:fd42g06 antibody
• zgc:55387 antibody

Protein level used designations for SAFB

HSP27 ERE-TATA-binding protein , HSP27 estrogen response element-TATA box-binding protein , Hsp27 ERE-TATA binding protein , SAB-B1 , SAF-B , glutathione S-transferase fusion protein , heat-shock protein (HSP27) estrogen response element and TATA box-binding protein , scaffold attachment factor B1 , SAF-B1 , scaffold attachment factor B2 , scaffold attachment factor B , scaffold attachment factor b , Scaffold attachment factor B