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anti-Human UBR5 Antibodies:
anti-Mouse (Murine) UBR5 Antibodies:
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Human Polyclonal UBR5 Primary Antibody for ICC, IF - ABIN151138
Nash, Chen, Salganik, Muzyczka: Identification of cellular proteins that interact with the adeno-associated virus rep protein. in Journal of virology 2008
Show all 7 Pubmed References
Human Polyclonal UBR5 Primary Antibody for IHC (p), IHC - ABIN249850
Garbow, Doherty, Schugar, Travers, Weber, Wentz, Ezenwajiaku, Cotter, Brunt, Crawford: Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet. in American journal of physiology. Gastrointestinal and liver physiology 2011
Show all 2 Pubmed References
BMI1 (show BMI1 Antibodies) and UBR5 repress the polymerase II (show POLR2F Antibodies) (Pol II (show 0 Antibodies))-mediated transcription at damaged sites
Results found that EDD was consistent with GOLPH3 (show GOLPH3 Antibodies) expression and also promoted the EMT (show ITK Antibodies) process and activated Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling in epithelial ovarian cancer.
UBR5 directly binds to the tumor suppressor esophageal cancer-related gene 4, increasing its ubiquitination to reducing the protein stability of ECRG4 (show C2orf40 Antibodies) to promote colorectal cancer progression.
Wnt (show WNT2 Antibodies)-dependent inactivation of the Groucho/TLE co-repressor by the HECT E3 ubiquitin ligase (show MUL1 Antibodies) Hyd/UBR5 is a key prerequisite that enables Armadillo/beta-catenin to activate transcription.
UBR5 downregulates proapoptotic MOAP-1 (show MOAP1 Antibodies) and suggest that UBR5 can confer cisplatin resistance in ovarian cancer.
Data suggest that UBR5 down-regulates levels of TRAF3 (show TRAF3 Antibodies), a key component of Toll (show TLR4 Antibodies)-like receptor signaling, via the miRNA pathway; p90RSK (show RPS6KA1 Antibodies) is an upstream regulator of UBR5; p90RSK (show RPS6KA1 Antibodies) phosphorylates UBR5 as required for translational repression of TRAF3 (show TRAF3 Antibodies) mRNA. (UBR5 = ubiquitin protein ligase E3 component n-recognin 5 protein; TRAF3 (show TRAF3 Antibodies) = TNF receptor-associated factor 3 (show TRAF3 Antibodies); p90RSK (show RPS6KA1 Antibodies) = 90 kDa ribosomal protein S6 (show RPS6 Antibodies) kinase (show RPS6KB1 Antibodies))
Data show that ubiquitin protein ligase E3 component n-recognin 5 protein (UBR5) bound the tumor suppressor gastrokine 1 (GKN1 (show GKN1 Antibodies)) and increased its ubiquitination to reduce the protein stability of GKN1 (show GKN1 Antibodies).
Findings unveil UBR5 as a novel and critical regulator of tumor growth, metastasis, and immune response in triple negative breast cancer.
Study highlights many functional biological role of UBR5 especially in cancer where it seems to be a key regulator of cell signaling. [review]
Colony-formation assays and soft agar assays show that gain of function of TIP60 or depletion of EDD1 in HPV-positive cervical cancer cells significantly inhibits cell growth in vitro
Hence, while loss of UBR5 perturbed Hedgehog (show SHH Antibodies) signalling in the developing limb, there were no obvious morphological defects.
UBR5-mediated ATMIN (show ATMIN Antibodies) ubiquitination is a vital event for ATM (show ATM Antibodies) pathway selection and activation in response to DNA damage
a novel function of RIP1 (show RALBP1 Antibodies) kinase involving its interaction with EDD to regulate JNK (show MAPK8 Antibodies) activation and TNFalpha (show TNF Antibodies) production.
Silencing Edd1 with shRNA in mouse embryonic stem cells significantly suppressed their growth.
The SCF (show KITLG Antibodies) E3 ligase complex containing Fbxo40 (show FBXO40 Antibodies) directly ubiquitinates IRS1 (show IRS1 Antibodies), and this activity is enhanced by increased tyrosine phosphorylation of IRS1 (show IRS1 Antibodies).
Through the PABC domain, EDD participates in miRNA silencing by recruiting downstream effectors.
UBR5 can attenuate myocardin (show MYOCD Antibodies) protein degradation resulting in increased myocardin (show MYOCD Antibodies) protein expression without affecting myocardin (show MYOCD Antibodies) mRNA expression.
Results suggest that Edd has an essential role in extraembryonic development.
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.
E3 identified by differential display
, E3 ubiquitin protein ligase, HECT domain containing, 1
, E3 ubiquitin-protein ligase UBR5
, E3 ubiquitin-protein ligase, HECT domain-containing 1
, hyperplastic discs protein homolog
, progestin induced protein
, progestin-induced protein
, ubiquitin-protein ligase
, extraembryonic development