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SYK mediates the actions of EPO and GM-CSF and coordinates with TGF-beta in erythropoiesis.
Exome sequencing identified candidate variants, including a missense mutation in DUOX2 that impaired its function and a frameshift mutation in CSF2RB that was associated with Crohn's Disease in an independent cohort of Ashkenazi Jewish individuals.
In a genetic analysis of Ashkenazi Jewish individuals, we associated Crohn's Disease with a frameshift mutation in CSF2RB. Intestinal monocytes from carriers of this mutation had reduced responses to granulocyte-macrophage colony-stimulating factor, providing an additional mechanism for alterations to the innate immune response in individuals with Crohn's Disease.
VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF and MED14
These data suggest that expression of GM-CSF and its receptor subunits by colon tumors may be a useful marker for prognosis
This study reveals a novel functional role of clathrin-coated structure in GMR signaling and the oncogenesis of JAK2V617F.
JAK kinase binding to betac requires the presence of three critical betac lysine residues, and this binding event is essential for receptor ubiquitination, endocytosis, and signaling.
Over expression of IL-3Ralpha and truncated mutation of hbetac may be involved in proliferation and differentiation block in NB4 cells.
Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils
The results of the study support CSF2RB as a risk factor common to both schizophrenia and major depression in the Chinese Han population.
Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations [case report]
the up-regulation of IL-3Rbeta expression may contribute to the maintenance of proliferation rather than cell differentiation.
The beta1 integrin-interacting domain in the extracellular domain of IL-3Rbeta was identified. A fragment of a protein corresponding to domain 4 of IL-3Rbeta prevented IL-3-mediated arterial morphogenesis and endothelial cell migration.
the domain 1 D-E loop disulfide of hbetac and beta(IL-3) have roles in maintaining the precise positions of ligand-binding residues necessary for normal high affinity binding and signaling
Two different modes of beta c binding are utilized in the presence of the hIL-3R alpha isoforms.
Data show that Deletion of the Ig-like domain of GM-CSFRalpha abolished direct GM-CSF binding and decreased growth signalling in the presence of hbetac.
hGM-CSF activation of hGM/beta(c)with or w/o the hbeta(c) subunit, promoted primitive phenotype maintenance, indicating that the hGM Ralpha chain cytosolic domain is needed for differentiation mediated by the hGM Ralpha, beta(c) receptor complex.
soluble forms of the GM-CSF receptor alpha chain and beta chain were produced and a novel mechanism of receptor assembly was demonstrated
JAK2 activation mediates cross-talk between extracellular domain mutants of the beta-subunit of the GM-CSF receptor and EpoR
Interleukin-3 binding to the human betac receptor involves functional epitopes formed by domains 1 and 4 of different protein chains
IL-3 signaling does not contribute to Jak2 V617F myeloproliferative neoplasm pathogenesis.
blockage of betaCR abrogated the EPO-conferred anti-inflammatory action on oxLDL-induced production of macrophage inflammatory protein-2
Deletion of the Csf2rb gene slows the progression of chronic myelomonocytic leukemia in mice.
Increased levels of Csf2rb on hematopoietic stem cells lead to expansion of these populations in ApoE(-/-) BM-transplanted Ldlr(-/-) mice, contributing to monocytosis and increased lesional macrophage content.
Erythropoietin attenuates the impaired systolic contractility associated with sepsis by activation of the beta-common receptor.
Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI and the IL-3 receptor.
Csf-2 receptor acts in the steady state to promote the survival & homeostasis of nonlymphoid tissue-resident CD103(+) & CD11b(+) DCs. It is dispensable for the differentiation & innate function of inflammatory DCs during acute injuries.
GM-CSF can regulate beta-catenin stability, most likely via GSK3b.
Suggest that beta common receptor may play an integrative role in the erythropoietin signaling-mediated activation of eNOS in endothelial cells.
NF-kappaB activation by beta(c) is dependent on TNFR-associated factor (TRAF)6; association of TRAF6 with beta(c) requires a consensus-binding motif found in other molecules known to interact with TRAF6.
Interleukin-3 binding to the murine betaIL-3 receptor involves functional epitopes formed by domains 1 and 4 of different protein chains
A previously unrecognized negative signaling role for Tyr577 in beta(c); uncoupling Shc from cytokine receptors enhances PI3K signaling as well as survival and proliferation.
Ligand-binding and receptor activation are not critically dependent on individual N-glycosylation sites within the IL-3- and IL-5-receptor common beta-subunit.
Although endogenous GM-CSF is not required to induce tumor immunity, signaling through betac receptor is critically needed for efficient cancer vaccination in both genetically modified GM-CSF-secreting tumor cells and a spontaneously immunogenic models.
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP).
cytokine receptor common subunit beta
, interleukin 3 common beta chain
, colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage)
, colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
, interleukin 3 receptor beta common
, cytokine receptor common subunit beta-like
, GM-CSF/IL-3/IL-5 receptor common beta subunit
, GM-CSF/IL-3/IL-5 receptor common beta-chain
, colony-stimulating factor-2 receptor, beta, low-affinity
, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity)
, CD131 antigen
, beta c
, common beta chain
, interleukin-5 receptor beta chain