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SYK (show SYK Proteins) mediates the actions of EPO (show EPO Proteins) and GM-CSF (show CSF2 Proteins) and coordinates with TGF-beta (show TGFB1 Proteins) in erythropoiesis.
Exome sequencing identified candidate variants, including a missense mutation in DUOX2 (show DUOX2 Proteins) that impaired its function and a frameshift mutation in CSF2RB that was associated with Crohn's Disease in an independent cohort of Ashkenazi Jewish individuals.
In a genetic analysis of Ashkenazi Jewish individuals, we associated Crohn's Disease with a frameshift mutation in CSF2RB. Intestinal monocytes from carriers of this mutation had reduced responses to granulocyte-macrophage colony-stimulating factor (show CSF2 Proteins), providing an additional mechanism for alterations to the innate immune response in individuals with Crohn's Disease.
VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF and MED14
These data suggest that expression of GM-CSF (show CSF2 Proteins) and its receptor subunits by colon tumors may be a useful marker for prognosis
This study reveals a novel functional role of clathrin-coated structure in GMR (show CSF2RA Proteins) signaling and the oncogenesis of JAK2V617F.
JAK (show JAK3 Proteins) kinase binding to betac requires the presence of three critical betac lysine residues, and this binding event is essential for receptor ubiquitination, endocytosis, and signaling.
Granulocyte/macrophage colony-stimulating factor (show CSF2 Proteins) causes a paradoxical increase in the BH3-only (show BBC3 Proteins) pro-apoptotic protein Bim (show BCL2L11 Proteins) in human neutrophils
The results of the study support CSF2RB as a risk factor common to both schizophrenia and major depression in the Chinese Han population.
Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations [case report]
IL-3 (show IL-3 Proteins) signaling does not contribute to Jak2 (show JAK2 Proteins) V617F myeloproliferative neoplasm pathogenesis.
blockage of betaCR abrogated the EPO (show EPO Proteins)-conferred anti-inflammatory action on oxLDL-induced production of macrophage inflammatory protein-2 (show CXCL2 Proteins)
Deletion of the Csf2rb gene slows the progression of chronic myelomonocytic leukemia in mice.
Increased levels of Csf2rb on hematopoietic stem cells lead to expansion of these populations in ApoE (show APOE Proteins)(-/-) BM-transplanted Ldlr (show LDLR Proteins)(-/-) mice, contributing to monocytosis and increased lesional macrophage content.
Erythropoietin (show EPO Proteins) attenuates the impaired systolic contractility associated with sepsis by activation of the beta-common receptor.
Findings indicate that SLP-76 (show LCP2 Proteins) is an essential signaling component for basophil activation downstream of both FcepsilonRI (show FCER1A Proteins) and the IL-3 (show IL-3 Proteins) receptor.
Csf-2 (show CSF2 Proteins) receptor acts in the steady state to promote the survival & homeostasis of nonlymphoid tissue-resident CD103 (show ITGAE Proteins)(+) & CD11b (show ITGAM Proteins)(+) DCs. It is dispensable for the differentiation & innate function of inflammatory DCs during acute injuries.
GM-CSF can regulate beta-catenin stability, most likely via GSK3b.
Suggest that beta common receptor may play an integrative role in the erythropoietin (show EPO Proteins) signaling-mediated activation of eNOS (show NOS3 Proteins) in endothelial cells.
NF-kappaB (show NFKB1 Proteins) activation by beta(c) is dependent on TNFR (show TNFRSF1A Proteins)-associated factor (TRAF)6 (show TRAF6 Proteins); association of TRAF6 (show TRAF6 Proteins) with beta(c) requires a consensus-binding motif found in other molecules known to interact with TRAF6 (show TRAF6 Proteins).
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP).
cytokine receptor common subunit beta
, interleukin 3 common beta chain
, colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage)
, colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
, interleukin 3 receptor beta common
, cytokine receptor common subunit beta-like
, GM-CSF/IL-3/IL-5 receptor common beta subunit
, GM-CSF/IL-3/IL-5 receptor common beta-chain
, colony-stimulating factor-2 receptor, beta, low-affinity
, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity)
, CD131 antigen
, beta c
, common beta chain
, interleukin-5 receptor beta chain