Browse our anti-IL-6 Receptor (IL6R) Antibodies

Full name:: anti-Interleukin-6 Receptor Antibodies (IL6R)

On www.antibodies-online.com are 294 Interleukin-6 Receptor (IL6R) Antibodies from 31 different suppliers available. Additionally we are shipping IL-6 Receptor Kits (63) and IL-6 Receptor Proteins (46) and many more products for this protein. A total of 421 IL-6 Receptor products are currently listed.

Synonyms:: CD126, gp80, IL-6R, IL-6R-1, IL-6RA, IL-6Ralpha, IL6Q, Il6r, IL6R1, Il6ra, IL6RQ

list all antibodies	Gene Name	GeneID	UniProt
	IL6R	3570	P08887
	IL6R	24499
	IL6R	16194	P22272
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Most Popular Reactivities for anti-IL-6 Receptor (IL6R) Antibodies

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anti-Human IL-6 Receptor Antibodies:

anti-Rat (Rattus) IL-6 Receptor Antibodies:

anti-Mouse (Murine) IL-6 Receptor Antibodies:

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Relevant Pathways for anti-IL-6 Receptor Antibodies

Growth Factor Binding

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Top referenced anti-IL-6 Receptor Antibodies

Human Monoclonal IL-6 Receptor Primary Antibody for ELISA - ABIN2688946 : Müller-Newen, Köhne, Keul, Hemmann, Müller-Esterl, Wijdenes, Brakenhoff, Hart, Heinrich: Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing. in European journal of biochemistry / FEBS 1996 (PubMed)
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Human Monoclonal IL-6 Receptor Primary Antibody for CyTOF, ELISA (Capture) - ABIN4899503 : Hurst, Wilkinson, McLoughlin, Jones, Horiuchi, Yamamoto, Rose-John, Fuller, Topley, Jones: Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. in Immunity 2001 (PubMed)
Show all 15 Pubmed References
Human Monoclonal IL-6 Receptor Primary Antibody for CyTOF, ELISA (Capture) - ABIN4899502 : Hurst, McLoughlin, Monslow, Owens, Morgan, Fuller, Topley, Jones: Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. in Journal of immunology (Baltimore, Md. : 1950) 2002 (PubMed)
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Human Monoclonal IL-6 Receptor Primary Antibody for FACS, ELISA - ABIN2688945 : Hirano, Nakajima, Hibi: Signaling mechanisms through gp130: a model of the cytokine system. in Cytokine & growth factor reviews 1998 (PubMed)
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Human Monoclonal IL-6 Receptor Primary Antibody for IHC (fro), FACS - ABIN1383672 : Dubois, Massacrier, Vanbervliet, Fayette, Brière, Banchereau, Caux: Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes. in Journal of immunology (Baltimore, Md. : 1950) 1998 (PubMed)
Show all 9 Pubmed References
Mouse (Murine) Polyclonal IL-6 Receptor Primary Antibody for CyTOF, ELISA (Capture) - ABIN4899510 : Chalaris, Rabe, Paliga, Lange, Laskay, Fielding, Jones, Rose-John, Scheller: Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. in Blood 2007 (PubMed)
Show all 8 Pubmed References
Human Monoclonal IL-6 Receptor Primary Antibody for FACS - ABIN1383676 : Lebeau, Montero Julian, Wijdenes, Müller-Newen, Dahmen, Chérel, Heinrich, Brailly, Hallet, Godard, Minvielle, Jacques: Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties. in FEBS letters 1997 (PubMed)
Show all 5 Pubmed References
Mouse (Murine) Polyclonal IL-6 Receptor Primary Antibody for ELISA (Detection), FACS - ABIN4899507 : Osuchowski, Siddiqui, Copeland, Remick: Sequential ELISA to profile multiple cytokines from small volumes. in Journal of immunological methods 2005 (PubMed)
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Mouse (Murine) Monoclonal IL-6 Receptor Primary Antibody for CyTOF, FACS - ABIN4899509 : Bailey, Huang, Kam, Farzan: Ifitm3 limits the severity of acute influenza in mice. in PLoS pathogens 2012 (PubMed)
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Human Monoclonal IL-6 Receptor Primary Antibody for FACS - ABIN1383675 : Mouthon, Freund, Titeux, Katz, Guichard, Breton-Gorius, Vainchenker: Growth and differentiation of the human megakaryoblastic cell line (ELF-153): a model for early stages of megakaryocytopoiesis. in Blood 1994 (PubMed)
Show all 2 Pubmed References

More Antibodies against IL-6 Receptor Interaction Partners

Zebrafish Interleukin-6 Receptor (IL6R) interaction partners

The expression of IL-6, IL-6R and gp130 transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.

Human Interleukin-6 Receptor (IL6R) interaction partners

sIL (show PMEL Antibodies)-6R may be a useful biomarker to assess insulin (show INS Antibodies) resistance among morbidly obese subjects
Study identified variants associated with the age of onset of Alzheimer's disease in APOE (show APOE Antibodies) varepsilon4 carriers. Across five datasets, p.D358A had a meta P = 3 x10-4 and an odds ratio = 1.3, 95% confidence interval 1.12 -1.48. Study suggests that a common coding region variant of the IL-6 (show IL6 Antibodies) receptor results in neuroinflammatory changes that may influence the age of onset of Alzheimer's disease in APOE (show APOE Antibodies) varepsilon4 carriers.
IL-6R protein expression on plasma membrane of ovarian cancer cells mediates enhanced cell migration/invasiveness in response to IL6 (show IL6 Antibodies) in ascites.
IL6R protein levels were higher in bone than in lymph node and visceral metastases of castration-resistant prostate cancer.
study focused on IL-6 (show IL6 Antibodies) and activation of its receptors gp80 (show CLU Antibodies) and gp130 (show IL6ST Antibodies) in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet (show FBXL15 Antibodies) Kit, Unifast, and Duralay on control of inflammation
In the present study, the authors show that deletion of a triple serine (3S) motif (Ser (show SIGLEC1 Antibodies)-359 to Ser (show SIGLEC1 Antibodies)-361) adjacent to the cleavage site is sufficient to prevent IL-6R cleavage by ADAM17 (show ADAM17 Antibodies), but not ADAM10 (show ADAM10 Antibodies). We find that the impaired shedding is caused by the reduced distance between the cleavage site and the plasma membrane.
IL6R SNPs are associated with simultaneously high CRP (show CRP Antibodies), LDL and ApoB (show APOB Antibodies) levels.
The sgp130, IL-6 (show IL6 Antibodies), and sIL (show PMEL Antibodies)-6R concentrations were statistically significantly elevated in patients with diabetic retinopathy (DR), suggesting a probable contributing role of the IL-6 (show IL6 Antibodies) trans-signaling pathway to the pathophysiology of DR.
The mRNA expression of IL6R was inversely correlated with miR (show MLXIP Antibodies)-449a in osteosarcoma tissues. In addition, JAK1 (show JAK1 Antibodies)/STAT3 (show STAT3 Antibodies) signaling pathway was regulated by circ_0009910/miR (show MLXIP Antibodies)-449a/IL6R axis.
IL-6 receptor blockade has an effect on high-sensitivity troponin T and NT-proBNP in rheumatoid arthritis

Pig (Porcine) Interleukin-6 Receptor (IL6R) interaction partners

IL-6sR and gp130 (show ANPEP Antibodies), but not IL-6R alpha, play important roles in regulation of granulosa cell survival

Cow (Bovine) Interleukin-6 Receptor (IL6R) interaction partners

Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Antibodies) and IL-6 (show IL6 Antibodies)/sIL (show STIL Antibodies)-6R in causing proteoglycan (show Vcan Antibodies) degradation in human and bovine cartilage.

Mouse (Murine) Interleukin-6 Receptor (IL6R) interaction partners

In the CNS, LPS (show TLR4 Antibodies) administration had the greatest effect on IL-6R mRNA.
IL-6 (show IL6 Antibodies) Receptor is overexpressed in glioma, and it can be used for targeted delivery of the therapeutic ING4 (show ING4 Antibodies) to the tumor.
role for IL-6R expression in regulating RBC (show CACNA1C Antibodies) alloimmunization
There are functional interleukin-6 receptor-alpha on tanycytes at the bottom of the third ventricle, in agreement with the possibility that ventricular administration of IL-6 (show IL6 Antibodies) decreases obesity in mice via an effect on this cell type.
we present evidence for the role of M2 phenotype TAM (show CCNA1 Antibodies) in IL-6 (show IL6 Antibodies) receptor-mediated signals, particularly tyrosine phosphorylation of STAT3 (show STAT3 Antibodies), responsible for the prosurvival adaptation of tumor cells to hypoxia.
TNF (show TNF Antibodies)/IL-6 (show IL6 Antibodies) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (show NFATC1 Antibodies), DNAX-activation protein 12 (show TYROBP Antibodies), and cell proliferation
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Interleukin-6 receptor alpha may have a role in skin lesions in a murine model of systemic lupus erythematosus
findings identify TRAF3 (show TRAF3 Antibodies) and PTPN22 (show PTPN22 Antibodies) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (show TRAF3 Antibodies) in the regulation of plasma cell differentiation
Data show that blockade of interleukin-6 receptor by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs (show UGCG Antibodies)) and inhibit the bone loss they cause.

IL-6 Receptor (IL6R) Antigen Profile

Antigen Summary

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Alternative names and synonyms associated with IL-6 Receptor (IL6R)

interleukin 6 receptor (IL6R) antibody
interleukin 6 receptor (il6r) antibody
interleukin 6 receptor (Il6r) antibody
interleukin 6 receptor, alpha (Il6ra) antibody

CD126 antibody
gp80 antibody
IL-6R antibody
IL-6R-1 antibody
IL-6RA antibody
IL-6Ralpha antibody
IL6Q antibody
Il6r antibody
IL6R1 antibody
Il6ra antibody
IL6RQ antibody

Protein level used designations for IL6R

interleukin 6 receptor , interleukin 6 receptor alpha , interleukin-6 receptor subunit alpha , CD126 antigen , IL-6 receptor subunit alpha , IL-6R 1 , membrane glycoprotein 80 , IL-6R subunit alpha , IL-6R-alpha , IL-6RA , interleukin 6 receptor, alpha , IL-6 receptor alpha chain

GENE ID	SPECIES
469506	Pan troglodytes
100135755	Danio rerio
3570	Homo sapiens
24499	Rattus norvegicus
101085689	Felis catus
399522	Sus scrofa
612271	Canis lupus familiaris
507359	Bos taurus
100730490	Cavia porcellus
101103369	Ovis aries
100347752	Oryctolagus cuniculus
16194	Mus musculus

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Show all anti-Interleukin-6 Receptor (IL6R) Antibodies with Pubmed References