IL-6 Receptor antibody (AA 20-365)

Catalog No. ABIN7092952

The Rabbit Monoclonal anti-IL-6 Receptor antibody is suitable to detect IL-6 Receptor in samples from Human. It has been validated for FACS and ELISA.

Quick Overview for IL-6 Receptor antibody (AA 20-365) (ABIN7092952)

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This IL-6 Receptor antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA

Clone: DM152

Product Details anti-IL-6 Receptor Antibody

Binding Specificity: AA 20-365

Purpose: Anti-IL6R antibody(DM152), Rabbit mAb

Purification: Purified from cell culture supernatant by affinity chromatography

Immunogen: Recombinant human IL6R(Leu20-Pro365) (ABIN6964085) produced by using human HEK293 cells

Isotype: IgG

Application Details

Application Notes: ELISA 1:5000-10000, Flow Cyt 1:100

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for IL-6 Receptor

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Alternative Name: IL6R

Background: Synonyms:CD126, gp80, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ
Description:This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Molecular Weight: 51.5KDa

UniProt: P08887

Pathways: JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints