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anti-Mouse (Murine) IL15 Antibodies:
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Human Monoclonal IL15 Primary Antibody for FACS - ABIN4897621
Anguille, Van Acker, Van den Bergh, Willemen, Goossens, Van Tendeloo, Smits, Berneman, Lion: Interleukin-15 Dendritic Cells Harness NK Cell Cytotoxic Effector Function in a Contact- and IL-15-Dependent Manner. in PLoS ONE 2015
Show all 8 Pubmed References
Human Monoclonal IL15 Primary Antibody for CyTOF, FACS - ABIN4900390
Marra, Mathew, Grigoriadis, Wu, Kyle-Cezar, Watkins, Rashid, De Rinaldis, Hessey, Gazinska, Hayday, Tutt: IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers. in Cancer research 2014
Show all 6 Pubmed References
Human Monoclonal IL15 Primary Antibody for CyTOF, FACS - ABIN4900389
Ong, Hamid, Travers, Strickland, Al Kerithy, Boguniewicz, Leung: Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis. in Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 6 Pubmed References
Human Monoclonal IL15 Primary Antibody for - ABIN1383961
Bernard, Harb, Mortier, Quéméner, Meloen, Vermot-Desroches, Wijdeness, van Dijken, Grötzinger, Slootstra, Plet, Jacques: Identification of an interleukin-15alpha receptor-binding site on human interleukin-15. in The Journal of biological chemistry 2004
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Human Polyclonal IL15 Primary Antibody for FACS, WB - ABIN4900388
Tejman-Yarden, Zlotnik, Lewis, Etzion, Chaimovitz, Douvdevani: Renal cells express a functional interleukin-15 receptor. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2005
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Human Monoclonal IL15 Primary Antibody for FACS - ABIN4897620
Ferlazzo, Pack, Thomas, Paludan, Schmid, Strowig, Bougras, Muller, Moretta, Münz: Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. in Proceedings of the National Academy of Sciences of the United States of America 2004
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Human Polyclonal IL15 Primary Antibody for ELISA, WB - ABIN4324547
Schneider, Mohebiany, Ifergan, Beauseigle, Duquette, Prat, Arbour: B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients. in Journal of immunology (Baltimore, Md. : 1950) 2011
Human Polyclonal IL15 Primary Antibody for Func, IHC (p) - ABIN2474939
Miller: T4 DNA polymerase (gene 43) is required in vivo for repair of gaps in recombinants. in Journal of virology 1975
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Human Monoclonal IL15 Primary Antibody for FACS - ABIN4897618
Pangrazzi, Meryk, Naismith, Koziel, Lair, Krismer, Trieb, Grubeck-Loebenstein: "Inflamm-aging" influences immune cell survival factors in human bone marrow. in European journal of immunology 2017
T cells in chimpanzees infected with human immunodeficiency virus express surface interleukin-15.
CD3 (show CD3 Antibodies)(-) CD8 (show CD8A Antibodies)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma (show IFNG Antibodies), and that IL-15 elicits IFN-gamma (show IFNG Antibodies) production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 (show CD8A Antibodies) antigen, IFN-gamma (show IFNG Antibodies)]
the protective effect on metastasis was lost upon patrolling monocyte or NK cell depletion, IL15 neutralization, or IFNgamma ablation. The combined analysis of these approaches allowed us to establish a hierarchy in which patrolling monocytes, making IL15 in response to primary tumors, activate NK cells and IFNg (show IFNG Antibodies) production that then inhibit lung metastasis formation.
an IL-15 isoform lacking exon-6, IL-15DeltaE6, generated by alternative splicing events of activated immune cells, including macrophages and B cells, is reported.
IL-15, but not IL-15Ralpha, is required for the development of spontaneous and virus-induced Type 1 diabetes.
These data demonstrate that mice with an endogenous IL-15 deficiency are susceptible to the development of severe, enhanced Th2-mediated allergic airway disease, which can be regulated by CD8 (show CD8A Antibodies)(+) T cells.
IL-15 induces the activation and survival of effector immune cells that are necessary for its antitumoral activity; but, long-term exposure to IL-15 is associated with the development of important side effects mainly mediated by IFN-gamma (show IFNG Antibodies)-producing T-cells
findings indicated that IL-15 plays an important role in preventing leukemia development.
NK cells activated by IL-4 (show IL4 Antibodies) in cooperation with IL-15 exhibit distinctive characteristics with enhanced immunologic cytotoxicity.
Genetic ablation of the IL2Rbeta chain on CD8 (show CD8A Antibodies)(+) T cells restrains inhibitory receptor induction, in particular 2B4 (show CD244 Antibodies) and Tim-3 (show HAVCR2 Antibodies); precludes terminal differentiation of highly defective PD-1 (show PDCD1 Antibodies)(hi) effectors; and rescues memory T-cell development and responsiveness to IL-7 (show IL7 Antibodies)-dependent signals. Together, we ascribe a previously unexpected role to IL-2 (show IL2 Antibodies) and IL-15 as instigators of CD8 (show CD8A Antibodies)(+) T-cell exhaustion during chronic viral infe...
aerobic interval training enhanced the anti-inflammatory indices IL-10 (show IL10 Antibodies)/TNF-alpha (show TNF Antibodies) ratio and IL-15 expression in skeletal muscle in tumor-bearing mice.
this study reveals the function of IL-15 in astrocyte survival via Akt (show AKT1 Antibodies) phosphorylation in response to OGD (show FGFR1 Antibodies)-induced damage.
These data support the combinatorial approach of in situ suppression of the PD-L inhibitory checkpoints with DC-mediated IL15 transpresentation to promote antigen-specific T-cell responses and, ultimately, contribute to graft-versus-tumor immunity
These data suggest that TLR2 activation is involved in the induction of IL-15 production by primary Sjogren's syndrome salivary gland epithelial cells and promotes inflammation through NF-kappaB (show NFKB1 Antibodies) activation.
Transgenic expression of IL15 is an appealing strategy to enhance CAR T-cell effector function. We tested this approach in our IL13Ralpha2-positive glioma model in which limited IL13Ralpha2-CAR T-cell persistence results in recurrence of antigen-positive gliomas. T cells were genetically modified with retroviral vectors encoding IL13Ralpha2-CARs or IL15 (IL13Ralpha2-CAR.IL15 T cells).
PLX4032, a selective BRAF (show BRAF Antibodies)-i, has no inhibitory effect either on NK cell proliferation in response to cytokines IL-2 (show IL2 Antibodies) or IL-15
this review will focus on IL-15 biology in NK cells and proposes the development novel therapies aimed at this pathway in humans
IL-15 levels were found to be elevated in depressed patients with asthma.
this paper show that IL-15 boosts the function and migration of human terminally differentiated CD8 (show CD8A Antibodies)+ T cells by inducing a unique gene signature
inhibits the Ca(2 (show CA2 Antibodies)+)-induced differentiation of keratinocytes, mainly via the attenuation of Ca(2 (show CA2 Antibodies)+)-stimulated PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) signalling
The 161533 TriKE induced superior NK cell cytotoxicity, degranulation, and cytokine production against CD33 (show CD33 Antibodies)(+) HL-60 targets and increased NK survival and proliferation.
In this article, we review the functions, expression, and regulation of IL-15 for designing an improved IL-15-based therapy targeting the IL-15 signaling pathway.
Study identified two completely linked SNPs in the porcine IL15 promoter region that could alter IL15 transcription activity. As interleukin-15 can inhibit porcine adipocyte differentiation, these promoter mutations could affect intramuscular fat deposition by producing differential levels of muscle-derived interleukin-15.
Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes.
results demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV)infection could induce IL-15 production in macrophages/dendritic cells; data further show that upregulation of IL-15 by PRRSV requires PKC (show FYN Antibodies) and NF-kappaB (show NFKB1 Antibodies) pathways
IFN-gamma (show IFNG Antibodies) targets the adipocyte to induce IL-15 expression, thus indicating a possible role for the adipocyte in the regulation of T-cell function and muscle metabolism during the innate immune response
When induced by IFN-gamma (show IFNG Antibodies) or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response.
Increased function and survival of IL-15-transduced dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2 (show BCL2 Antibodies).
IL 15 generates a dramatic expansion of short-lived memory CD8 (show CD8A Antibodies) T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4 (show CD4 Antibodies)(+) and CD8 (show CD8A Antibodies)(+) T cells.
These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 (show CD4 Antibodies) + T cell compartment.
IL-15 secretion significantly correlates with the up-regulated expression of CD4 (show CD4 Antibodies) on memory CD4 (show CD4 Antibodies) T cells that is associated with increased permissiveness to simian immunodeficiency virus infection.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.