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anti-Human IL21 Antibodies:
anti-Mouse (Murine) IL21 Antibodies:
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Human Polyclonal IL21 Primary Antibody for ICC, IF - ABIN315232
Liu, Xia, Wu, Wu, Tang, Chen, Xu, Cong, Xu, Liu: Anti-tumour necrosis factor therapy enhances mucosal healing through down-regulation of interleukin-21 expression and T helper type 17 cell infiltration in Crohn's disease. in Clinical and experimental immunology 2013
Show all 5 Pubmed References
Human Polyclonal IL21 Primary Antibody for ICC, ELISA - ABIN1002621
Asao, Okuyama, Kumaki, Ishii, Tsuchiya, Foster, Sugamura: Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. in Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 3 Pubmed References
Mouse (Murine) Monoclonal IL21 Primary Antibody for FACS - ABIN4896832
Carrier, Whitters, Miyashiro, LaBranche, Ramon, Benoit, Ryan, Keegan, Guay, Douhan, Collins, Dunussi-Joannopoulos, Medley: Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells. in European journal of immunology 2012
Show all 2 Pubmed References
Mouse (Murine) Monoclonal IL21 Primary Antibody for FACS - ABIN4896831
Hondowicz, Batheja, Metzgar, Caton, Erikson: ICOS expression by effector T cells influences the ability of regulatory T cells to inhibit anti-chromatin B cell responses in recipient mice. in Journal of autoimmunity 2010
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Human Monoclonal IL21 Primary Antibody for ELISA - ABIN2689754
Leonard, Spolski: Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. in Nature reviews. Immunology 2005
Show all 2 Pubmed References
Human Monoclonal IL21 Primary Antibody for ELISA - ABIN2689755
Sivakumar, Foster, Clegg: Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. in Immunology 2004
Show all 2 Pubmed References
Mouse (Murine) Monoclonal IL21 Primary Antibody for CyTOF, FACS - ABIN4899869
Pot, Jin, Awasthi, Liu, Lai, Madan, Sharpe, Karp, Miaw, Ho, Kuchroo: Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. in Journal of immunology (Baltimore, Md. : 1950) 2009
Mouse (Murine) Monoclonal IL21 Primary Antibody for FACS - ABIN4896826
Lee, Rigby, Zotos, Tsai, Kawamoto, Marshall, Ramiscal, Chan, Gatto, Brink, Yu, Fagarasan, Tarlinton, Cunningham, Vinuesa: B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells. in The Journal of experimental medicine 2011
Human Monoclonal IL21 Primary Antibody for ICC, IF - ABIN4324913
Chen, Xiao, Lao, Wei, Liu, Zeng, Wang, Ouyang, Chen, Chan, Shi, Zheng, Kuang: Polarization of Tissue-Resident TFH-Like Cells in Human Hepatoma Bridges Innate Monocyte Inflammation and M2b Macrophage Polarization. in Cancer discovery 2016
These results suggest that cetuximab treatment in combination with IL-21 adjuvant therapy in patients with EGFR-positive pancreatic cancer results in significant NK cell activation, irrespective of KRAS mutation status, and may be a potential therapeutic strategy
serum IL-21 (show IL17C Antibodies) levels at 12 weeks treatment was significantly elevated, which can predict the EVR, and contributes to individualization of antiviral therapy in HBeAg-positive CHB+NAFLD (show TSC2 Antibodies) patients.
IL-23 (show IL23A Antibodies) activates gammadelta T cells in early stage PNS, which amplifies the Th17 cell population and leads to kidney injury through the secretion of IL-21 (show IL17C Antibodies).
IL-21 (show IL17C Antibodies) promotes the survival and CTLA-4 (show CTLA4 Antibodies) expression of Tregs and enhanced the suppressive capacity of Tregs during HIV infection. These results broaden the understanding of HIV pathogenesis and provide critical information for HIV interventions.
IL-21 (show IL17C Antibodies) are important in the pathophysiology of chronic rhinosinusitis with nasal polyposis
Data show that interleukin-21-primed cytotoxic T-cell lymphocytes (CTL) with cytotoxic T-lymphocyte associated protein 4 (CTLA-4 (show CTLA4 Antibodies)) blockade is safe and produces durable clinical responses.
These results indicate that significant increased IL-21 (show IL17C Antibodies) expression present within the adenoma/CRC (show CALR Antibodies) microenvironment might have a potential predicating significance for survival time in patients with CRC (show CALR Antibodies).
IL-21 (show IL17C Antibodies) modulates the effector functions of T, B and NK cells, which not only have key roles in antitumoral and antiviral immunity but also in exerting major effects on inflammatory responses promoting the development of autoimmune diseases.
CCL21 (show CCL21 Antibodies)/IL21 (show IL17C Antibodies)-armed oncolytic adenovirus enhances antitumor activity against TERT (show TERT Antibodies)-positive tumor cells.
Report efficient retroviral vector transduction of primary human natural killer cells that were stimulated by a combination of IL-2 (show IL2 Antibodies) and engineered K562 cells expressing membrane-bound IL-21 (show IL17C Antibodies) for cancer immunotherapy.
IL-6 (show IL6 Antibodies) is identified as a master regulator of IL-21 in effector CD8 (show CD8A Antibodies)(+) T cells.
Our work suggests that IL-21 regulates megakaryocyte development and platelet homeostasis. Thus, IL-21 may link immune responses to physiological or pathological platelet-dependent processes.
we identify novel distal regulatory elements in the mouse Il21 locus and demonstrate a dynamic long-range chromatin interaction between the Il21 promoter and these regulatory elements, which contributes to the regulated expression of IL-21
this study shows that IL-21 acts as a potent inhibitor of a IL-17A (show IL17A Antibodies)-producing T-cell subset during Mycobacterium bovis Bacillus infection
IL-21 may play an important role in the pathogenesis of SSc (show CYP11A1 Antibodies) as a Th17 effector cytokine, and IL-21 may induce the differentiation of Th17 cells in the BLM (show BLM Antibodies)-induced systemic sclerosis mouse model via Il21R (show IL21R Antibodies).
The data of this study suggested that an increase in astrocyte-derived IL-21 expression in hippocampal subregions following KA-induced seizures may have potent regulatory effects on epileptogenesis.
this study reveals a context-dependent role for IL-21 in sustaining effector phenotype CD8 (show CD8A Antibodies) T cells and influencing their migratory properties, accumulation, and functions.
Dysregulated development of IL-17 (show IL17A Antibodies)- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat.
results demonstrate that, in the setting of lupus-like CD4 (show CD4 Antibodies) T cell-driven B cell hyperactivity, IL-21 signaling on Ag-specific donor CD8 (show CD8A Antibodies) T cells is critical for CTL effector maturation whereas a lack of IL-21R (show IL21R Antibodies) downregulates CTL responses that would otherwise limit B cell hyperactivity and autoantibody production
Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21, IL21R (show IL21R Antibodies), and a series of genes associated with TFH cell development and function.
The results revealed that the peak expression of IL6 (show IL6 Antibodies) and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, interleukin-21 isoform