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anti-Rat (Rattus) IL6RA Antibodies:
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IL6R (show IL6R Antibodies) protein levels were higher in bone than in lymph node and visceral metastases of castration-resistant prostate cancer.
study focused on IL-6 (show IL6 Antibodies) and activation of its receptors gp80 (show CLU Antibodies) and gp130 (show IL6ST Antibodies) in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet (show FBXL15 Antibodies) Kit, Unifast, and Duralay on control of inflammation
In the present study, the authors show that deletion of a triple serine (3S) motif (Ser (show SIGLEC1 Antibodies)-359 to Ser (show SIGLEC1 Antibodies)-361) adjacent to the cleavage site is sufficient to prevent IL-6R cleavage by ADAM17 (show ADAM17 Antibodies), but not ADAM10 (show ADAM10 Antibodies). We find that the impaired shedding is caused by the reduced distance between the cleavage site and the plasma membrane.
IL6R (show IL6R Antibodies) SNPs are associated with simultaneously high CRP (show CRP Antibodies), LDL and ApoB (show APOB Antibodies) levels.
The sgp130, IL-6 (show IL6 Antibodies), and sIL (show PMEL Antibodies)-6R concentrations were statistically significantly elevated in patients with diabetic retinopathy (DR), suggesting a probable contributing role of the IL-6 (show IL6 Antibodies) trans-signaling pathway to the pathophysiology of DR.
The mRNA expression of IL6R (show IL6R Antibodies) was inversely correlated with miR (show MLXIP Antibodies)-449a in osteosarcoma tissues. In addition, JAK1 (show JAK1 Antibodies)/STAT3 (show STAT3 Antibodies) signaling pathway was regulated by circ_0009910/miR (show MLXIP Antibodies)-449a/IL6R (show IL6R Antibodies) axis.
IL-6 receptor blockade has an effect on high-sensitivity troponin T and NT-proBNP in rheumatoid arthritis
study demonstrates enhanced T cell responses to IL-6 (show IL6 Antibodies) in T1D due, in part, to an increase in IL-6R surface expression. Dysregulated IL-6 (show IL6 Antibodies) responsiveness may contribute to diabetes through multiple mechanisms including altered T cell trafficking
Enterovirus 71 antagonizes the antiviral activity of host STAT3 (show STAT3 Antibodies) and IL-6R with partial dependence on virus-induced miR (show MLXIP Antibodies)-124.
we present evidence for the role of M2 phenotype TAM (show CCNA1 Antibodies) in IL-6 (show IL6 Antibodies) receptor-mediated signals, particularly tyrosine phosphorylation of STAT3 (show STAT3 Antibodies), responsible for the prosurvival adaptation of tumor cells to hypoxia.
role for IL-6R expression in regulating RBC (show CACNA1C Antibodies) alloimmunization
There are functional interleukin-6 receptor-alpha (show IL6R Antibodies) on tanycytes at the bottom of the third ventricle, in agreement with the possibility that ventricular administration of IL-6 (show IL6 Antibodies) decreases obesity in mice via an effect on this cell type.
TNF (show TNF Antibodies)/IL-6 (show IL6 Antibodies) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (show NFATC1 Antibodies), DNAX-activation protein 12 (show TYROBP Antibodies), and cell proliferation
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Interleukin-6 receptor alpha (show IL6R Antibodies) may have a role in skin lesions in a murine model of systemic lupus erythematosus
findings identify TRAF3 (show TRAF3 Antibodies) and PTPN22 (show PTPN22 Antibodies) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (show TRAF3 Antibodies) in the regulation of plasma cell differentiation
Data show that blockade of interleukin-6 receptor (show IL6R Antibodies) by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs (show UGCG Antibodies)) and inhibit the bone loss they cause.
established that endogenous IL-6R of both human and murine origin is shed by ADAM17 (show ADAM17 Antibodies) in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (show ADAM10 Antibodies)
Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
IL-6 receptor subunit alpha
, IL-6R 1
, IL-6R subunit alpha
, interleukin 6 receptor, alpha
, interleukin-6 receptor subunit alpha
, CD126 antigen
, membrane glycoprotein 80
, IL-6 receptor alpha chain