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anti-Human LIF Antibodies:
anti-Mouse (Murine) LIF Antibodies:
anti-Rat (Rattus) LIF Antibodies:
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Mouse (Murine) Polyclonal LIF Primary Antibody for WB - ABIN3042667
Hu, Feng, Tang, Zhu, Lin, Yu: LIF upregulates expression of NK-1R in NHBE cells. in Mediators of inflammation 2007
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Human Polyclonal LIF Primary Antibody for IHC (p), WB - ABIN3043403
Gui, Xiong, Yang, Li, Huang: Effects of acupuncture on LIF and IL-12 in rats of implantation failure. in American journal of reproductive immunology (New York, N.Y. : 1989) 2012
Show all 5 Pubmed References
Human Polyclonal LIF Primary Antibody for IF (p), IHC (p) - ABIN737046
Liang, Zhou, Jiang, Zhang, Wang, Wang: Expression of LIF and LIFR in periodontal tissue during orthodontic tooth movement. in The Angle orthodontist 2011
Human Polyclonal LIF Primary Antibody for ELISA, ICC - ABIN4330945
Gao, Carson: Lewis lung carcinoma regulation of mechanical stretch-induced protein synthesis in cultured myotubes. in American journal of physiology. Cell physiology 2016
Cow (Bovine) Polyclonal LIF Primary Antibody for WB - ABIN2785833
Muntz, Malpass, McGonigle, Robertson, Weiden: Phase 2 study of intraperitoneal topotecan as consolidation chemotherapy in ovarian and primary peritoneal carcinoma. in Cancer 2008
Show all 2 Pubmed References
The expression of LIF was associated with tumor size and a poorer overall survival. Microarray and quantitative real-time polymerase chain reaction assessments suggest that LIF can facilitate tumor-promoting inflammation. Results indicate that LIF plays a role in maintaining cancer stem cells in chordomas.
study indicated impaired LIF expression levels only in women with unexplained infertility, while LIF-R (show LIFR Antibodies) expression was impaired in all sub-groups of infertile women.
findings illustrate that DeltaNp63alpha can inhibit the levels of LIF mRNA by direct transcription regulation and decrease LIF mRNA stability by suppressing the expression of Lnc-LIF-AS. An inverse interaction of LIF and DeltaNp63alpha expression was as well validated in clinical samples of cervical cancer, and high level of LIF in cervical cancers was related with poor patient survival.
ATF3 (show ATF3 Antibodies) plays a significant role in regulating human endometrial receptivity and embryo attachment in vitro via up-regulation of leukemia inhibitory factor.
Although further studies would be required to deconvolute the targets involved in LIF induction and to confirm activity of hits in more disease-relevant assays, our results have demonstrated the potential of the phenotypic approach to identify specific and chemically tractable small molecules that trigger the production of LIF in relevant cell lines
SNP 3951C/T of LIF may not be associated with in vitro fertilization and embryo transfer outcome in Iranian population.
In summary, this study has shown that LIF is implicated in the HG-mediated inhibition of osteoblast differentiation, via promoting STAT3 (show STAT3 Antibodies)/SOCS3 (show SOCS3 Antibodies) signaling. This study may provide insights into the signal pathway of HG-induced bone loss or delayed injured joint healing.
Cytokines of the LIF/CNTF (show CNTF Antibodies) family and metabolism
These results demonstrate the involvement of PIM (show PIM1 Antibodies) kinases in LIF-induced regulation in different trophoblastic cell lines which may indicate similar functions in primary cells.
Data suggest a 216-nucleotide proximal cis (show CISH Antibodies)-element in LIF mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis (show CISH Antibodies)-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin (show NCL Antibodies) and PCBP1 (show PCBP1 Antibodies), 2 trans-acting factors that bind to and stabilize LIF mRNA. [LIF = leukemia inhibitory factor; PCBP1 (show PCBP1 Antibodies) = poly(rC) binding protein 1 (show PCBP1 Antibodies)]
mouse embryonic stem cells inside microchambers formed colonies and expressed markers of pluripotency in the absence of feeders or pluripotency-inducing signals such as leukemia inhibitory factor.
lung epithelium, specifically alveolar type II cells, is the predominant site of LIF transcript induction in pneumonic mouse lungs.
LIF/STAT3 (show STAT3 Antibodies) and MEK (show MDK Antibodies)/ERK (show EPHB2 Antibodies) signaling in naive embryonic stem cell pluripotency, is reported.
LIF stimulates, in part, stem cell-derived cardiomyocyte regeneration by activating cardiac stem or precursor cells.
Our data show that absence of SOCS2 (show SOCS2 Antibodies) turns cardiomyocytes unresponsive to LIF-induced [Ca(2 (show CA2 Antibodies)+)] raise, indicating that endogenous levels of SOCS2 (show SOCS2 Antibodies) are crucial for full activation of LIF signaling in the heart.
These results establish that Bcl3 (show BCL3 Antibodies) positively regulates pluripotency genes and thus shed light on the mechanism of Bcl3 (show BCL3 Antibodies) as a downstream molecule of LIF/STAT3 (show STAT3 Antibodies) signaling in pluripotency maintenance.
The role of LIF in acetylcholine synthesis via the STAT3 (show STAT3 Antibodies), PI3 (show PI3 Antibodies) kinases, or cAMP-protein kinase A pathways, are reported.
Either LIF or EGF (show EGF Antibodies) is needed during development of pre-implantation embryo.
Our data suggest that LIF plays an important role in placentation in vivo and the maintenance of healthy pregnancy.
Despite common signal transduction mechanisms (JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies), MAPK (show MAPK1 Antibodies) and PI3K) LIF can have paradoxically opposite effects in different cell types including stimulating or inhibiting each of cell proliferation, differentiation and survival.
Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and the generation of cloned embryos.
Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 (show STAT3 Antibodies) markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Antibodies)-supplemented media.
LIF and IL-6 (show IL6 Antibodies) are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway.
favorable effect on litter size in pigs of the A allele for a SNP within the LIF gene
LIF (Leukemia inhibitory factor) mRNA was elevated in stented segments of coronary arteries; vascular smooth muscle cell proliferation was inhibited by LIF treatment in an in-vitro model of atherosclerosis
study found significant association of two diallelic polymorphisms in the porcine genes for leukaemia inhibitory factor (LIF) and retinol-binding protein 4 (RBP4 (show RBP4 Antibodies)) with number of piglets born alive (NBA) in two German pig lines
Studied the effects of leukemia inhibitory factor (LIF) on bovine oocyte maturation and early embryo development in vitro.
results suggest that leukemia inhibitory factor and macrophage-colony stimulating factor (show CSF2 Antibodies) are produced in the endometrium and may play different roles in early and mid-pregnancy
Leukemia inhibitory factor (LIF) can effectively accelerate the corneal nerve regeneration of rabbit eyes after LASIK surgery and decrease the occurrence of dry eye symptoms.
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, cholinergic differentiation factor
, differentiation inhibitory activity
, differentiation-inducing factor
, differentiation-stimulating factor
, hepatocyte-stimulating factor III
, human interleukin in DA cells
, melanoma-derived LPL inhibitor
, d factor
, leukemia inhibitory factor (cholinergic differentiation factor)
, cholinergic neuronal differentiation factor
, leukemia inhibitory factor
, Leukemia Inhibitory Factor (LIF)