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anti-Mouse (Murine) LIF Antibodies:
anti-Human LIF Antibodies:
anti-Rat (Rattus) LIF Antibodies:
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Mouse (Murine) Polyclonal LIF Primary Antibody for WB - ABIN3042667
Hu, Feng, Tang, Zhu, Lin, Yu: LIF upregulates expression of NK-1R in NHBE cells. in Mediators of inflammation 2007
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Human Polyclonal LIF Primary Antibody for IHC (p), WB - ABIN3043403
Gui, Xiong, Yang, Li, Huang: Effects of acupuncture on LIF and IL-12 in rats of implantation failure. in American journal of reproductive immunology (New York, N.Y. : 1989) 2012
Show all 5 Pubmed References
Human Polyclonal LIF Primary Antibody for ELISA, ICC - ABIN4330945
Gao, Carson: Lewis lung carcinoma regulation of mechanical stretch-induced protein synthesis in cultured myotubes. in American journal of physiology. Cell physiology 2016
Cow (Bovine) Polyclonal LIF Primary Antibody for WB - ABIN2785833
Muntz, Malpass, McGonigle, Robertson, Weiden: Phase 2 study of intraperitoneal topotecan as consolidation chemotherapy in ovarian and primary peritoneal carcinoma. in Cancer 2008
Show all 2 Pubmed References
Human Polyclonal LIF Primary Antibody for IF (p), IHC (p) - ABIN737046
Liang, Zhou, Jiang, Zhang, Wang, Wang: Expression of LIF and LIFR in periodontal tissue during orthodontic tooth movement. in The Angle orthodontist 2011
mouse embryonic stem cells inside microchambers formed colonies and expressed markers of pluripotency in the absence of feeders or pluripotency-inducing signals such as leukemia inhibitory factor.
Authors demonstrate heterozygous novel or rare LIFR (show LIFR Antibodies) mutations in 3.3% of CAKUT patients, and provide evidence that Lifr (show LIFR Antibodies) deficiency and deactivating LIFR (show LIFR Antibodies) mutations cause highly similar anomalies of the urogenital tract in mice and humans.
lung epithelium, specifically alveolar type II cells, is the predominant site of LIF transcript induction in pneumonic mouse lungs.
LIF/STAT3 (show STAT3 Antibodies) and MEK (show MDK Antibodies)/ERK (show EPHB2 Antibodies) signaling in naive embryonic stem cell pluripotency, is reported.
uterine expression of the LIFR (show LIFR Antibodies) is essential for embryo implantation; this further define the components of the LIF signaling pathway necessary for effective implantation.
LIF stimulates, in part, stem cell-derived cardiomyocyte regeneration by activating cardiac stem or precursor cells.
Our data show that absence of SOCS2 (show SOCS2 Antibodies) turns cardiomyocytes unresponsive to LIF-induced [Ca(2 (show CA2 Antibodies)+)] raise, indicating that endogenous levels of SOCS2 (show SOCS2 Antibodies) are crucial for full activation of LIF signaling in the heart.
OSM (mOSM) signals mainly via an OSM receptor (OSMR)-gp130 heterodimer and binds with only very low affinity to mLIFR.
These results establish that Bcl3 (show BCL3 Antibodies) positively regulates pluripotency genes and thus shed light on the mechanism of Bcl3 (show BCL3 Antibodies) as a downstream molecule of LIF/STAT3 (show STAT3 Antibodies) signaling in pluripotency maintenance.
The role of LIF in acetylcholine synthesis via the STAT3 (show STAT3 Antibodies), PI3 (show PI3 Antibodies) kinases, or cAMP-protein kinase A pathways, are reported.
Although further studies would be required to deconvolute the targets involved in LIF induction and to confirm activity of hits in more disease-relevant assays, our results have demonstrated the potential of the phenotypic approach to identify specific and chemically tractable small molecules that trigger the production of LIF in relevant cell lines
SNP 3951C/T of LIF may not be associated with in vitro fertilization and embryo transfer outcome in Iranian population.
In summary, this study has shown that LIF is implicated in the HG-mediated inhibition of osteoblast differentiation, via promoting STAT3 (show STAT3 Antibodies)/SOCS3 (show SOCS3 Antibodies) signaling. This study may provide insights into the signal pathway of HG-induced bone loss or delayed injured joint healing.
Cytokines of the LIF/CNTF (show CNTF Antibodies) family and metabolism
These results demonstrate the involvement of PIM (show PIM1 Antibodies) kinases in LIF-induced regulation in different trophoblastic cell lines which may indicate similar functions in primary cells.
Data suggest a 216-nucleotide proximal cis (show CISH Antibodies)-element in LIF mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis (show CISH Antibodies)-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin (show NCL Antibodies) and PCBP1 (show PCBP1 Antibodies), 2 trans-acting factors that bind to and stabilize LIF mRNA. [LIF = leukemia inhibitory factor; PCBP1 (show PCBP1 Antibodies) = poly(rC) binding protein 1 (show PCBP1 Antibodies)]
Leukemia inhibitory factor (LIF) - STAT3 (show STAT3 Antibodies) transcription factor (STAT3 (show STAT3 Antibodies)) signaling pathway is systemically dysregulated in in the endometrium of patients with recurrent/repeated implantation failure (RIFE).
Endometrial expression of LIF and LIFR (show LIFR Antibodies) is significantly reduced in the epithelial cells of infertile women.
LIF SNP T/G (rs929271) seems to be a susceptibility biomarker capable of predicting implantation efficiency and pregnancy outcomes.
Overexpression of LIF promotes Epithelial-mesenchymal transition and results in cancer.
Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and the generation of cloned embryos.
Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 (show STAT3 Antibodies) markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Antibodies)-supplemented media.
LIF and IL-6 (show IL6 Antibodies) are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway.
favorable effect on litter size in pigs of the A allele for a SNP within the LIF gene
LIF (Leukemia inhibitory factor) mRNA was elevated in stented segments of coronary arteries; vascular smooth muscle cell proliferation was inhibited by LIF treatment in an in-vitro model of atherosclerosis
study found significant association of two diallelic polymorphisms in the porcine genes for leukaemia inhibitory factor (LIF) and retinol-binding protein 4 (RBP4 (show RBP4 Antibodies)) with number of piglets born alive (NBA) in two German pig lines
Studied the effects of leukemia inhibitory factor (LIF) on bovine oocyte maturation and early embryo development in vitro.
results suggest that leukemia inhibitory factor and macrophage-colony stimulating factor (show CSF2 Antibodies) are produced in the endometrium and may play different roles in early and mid-pregnancy
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, differentiation-stimulating factor
, D factor
, cholinergic differentiation factor
, differentiation inhibitory activity
, differentiation-inducing factor
, hepatocyte-stimulating factor III
, human interleukin in DA cells
, melanoma-derived LPL inhibitor
, leukemia inhibitory factor (cholinergic differentiation factor)
, cholinergic neuronal differentiation factor
, leukemia inhibitory factor
, D-factor/LIF receptor
, LIF receptor
, leukemia inhibitory factor receptor alpha chain
, soluble differentiation-stimulating factor receptor