LIF antibody (Leukemia Inhibitory Factor) (AA 24-203)

Details for Product anti-LIF Antibody No. ABIN5692888
Antigen
  • CDF
  • DIA
  • HILDA
  • MLPLI
  • LIF, interleukin 6 family cytokine
  • leukemia inhibitory factor
  • LIF
  • Lif
Epitope
AA 24-203
12
10
8
7
6
4
4
3
3
2
2
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
83
38
26
11
9
6
4
2
2
2
2
1
1
1
Host
Rabbit
95
15
2
2
2
1
Clonality
Polyclonal
Conjugate
This LIF antibody is un-conjugated
4
2
2
2
2
2
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
104
43
37
17
15
9
7
7
6
4
2
1
1
1
Options
Brand Picoband™
Immunogen E. coli-derived mouse LIF recombinant protein (Position: S24-F203).
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for LIF detection. Tested with WB, ELISA(Cap) in Human,Mouse,Rat.
Plasmids, Primers & others Plasmids, Primers & others LIF products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Lif (LIF Antibody Abstract)
Background

Synonyms: Leukemia inhibitory factor, LIF, Differentiation-stimulating factor, D factor, Lif

Background: LIF is a pleiotropic cytokine produced at the maternal-fetal interface which has been shown to play an essential role in implantation in mice. This gene is mapped to 22q11-q12.2, between the Philadelphia translocation BCR gene and the breakpoint of the translocation in cell line GM2324 at 22q12.2. LIF is produced in high amounts by the human endometrium and the trophoblast itself, and LIF receptors are present on cytotrophoblast cells. LIF could, thus, play a role in modulating HLA-G production and immune tolerance at the maternal-fetal interface.

UniProt P09056
Pathways JAK-STAT Signaling, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Stem Cell Maintenance, Growth Factor Binding
Application Notes

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Application Details: Western blot, 0.1-0.5&mu,g/mL
ELISA(Cap), 1-5&mu,g/mL

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Buffer Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Supplier Images
Image no. 1 for anti-Leukemia Inhibitory Factor (LIF) (AA 24-203) antibody (ABIN5692888) Western blot analysis of LIF using anti-LIF antibody . Electrophoresis was performed...
Product cited in: Zhang, Liu, Liu, Zhou, Song, Cao, An: "miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression." in: PLoS ONE, Vol. 12, Issue 7, pp. e0179783, 2017 (PubMed).

Dong, Sui, Huang, Wang, Hu, Xiong, Wang, Zhang: "MicroRNA-223-3p suppresses leukemia inhibitory factor expression and pinopodes formation during embryo implantation in mice." in: American journal of translational research, Vol. 8, Issue 2, pp. 1155-63, 2016 (PubMed).

Hu, Feng, Tang, Zhu, Lin, Yu: "LIF upregulates expression of NK-1R in NHBE cells." in: Mediators of inflammation, Vol. 2006, Issue 5, pp. 84829, 2007 (PubMed).

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