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anti-MPL Antibodies

54 results:

anti-MPL antibody (Myeloproliferative Leukemia Virus Oncogene) Primary Antibody

MPL Reactivity: Human FACS, ELISA, WB Host: Mouse Monoclonal 1H2 unconjugated
Pubmed 2
Catalog No. ABIN969542
$448.80
Plus shipping costs $45.00
0.1 mg
local_shipping Shipping to: United States
Delivery in 3 to 4 Business Days

anti-MPL antibody (Myeloproliferative Leukemia Virus Oncogene) (AA 26-175) Primary Antibody

MPL Reactivity: Human ELISA, FACS, WB Host: Mouse Monoclonal 1D6B7 unconjugated
Catalog No. ABIN5611182
$448.80
Plus shipping costs $45.00
0.1 mg
local_shipping Shipping to: United States
Delivery in 3 to 4 Business Days

anti-MPL antibody (Myeloproliferative Leukemia Virus Oncogene) (Internal Region) Primary Antibody

MPL Reactivity: Human, Mouse, Rat ELISA, IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3187963
$396.83
Plus shipping costs $45.00
100 μL (More quantities available)
local_shipping Shipping to: United States
Delivery in 11 to 13 Business Days

anti-MPL antibody (Myeloproliferative Leukemia Virus Oncogene) Primary Antibody

MPL Reactivity: Human EIA, FACS, WB Host: Mouse Monoclonal 1H2 unconjugated
Catalog No. ABIN1105749
$592.90
Plus shipping costs $45.00
0.1 mg
local_shipping Shipping to: United States
Available

anti-MPL antibody (Myeloproliferative Leukemia Virus Oncogene) (AA 1-635) Primary Antibody

MPL Reactivity: Human IP, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN948145
$510.67
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 11 to 12 Business Days

anti-MPL antibody (Myeloproliferative Leukemia Virus Oncogene) (AA 1-635) Primary Antibody

MPL Reactivity: Human FACS, WB Host: Mouse Polyclonal unconjugated
Catalog No. ABIN517994
$524.00
Plus shipping costs $45.00
50 μg
local_shipping Shipping to: United States
Delivery in 11 to 12 Business Days

anti-MPL antibody (Myeloproliferative Leukemia Virus Oncogene) (AA 321-370) Primary Antibody

MPL Reactivity: Human, Mouse, Rat ELISA, IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6283334
$318.71
Plus shipping costs $45.00
50 μL
local_shipping Shipping to: United States
Delivery in 11 to 13 Business Days

anti-MPL antibody (Myeloproliferative Leukemia Virus Oncogene) (AA 311-460) Primary Antibody

MPL Reactivity: Human ELISA, ICC, IHC (fro), IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6996098
$332.00
Plus shipping costs $45.00
200 μL
local_shipping Shipping to: United States
Available

anti-MPL antibody (Myeloproliferative Leukemia Virus Oncogene) (AA 66-260) Primary Antibody

MPL Reactivity: Mouse ICC, IHC, IP, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6996099
$342.00
Plus shipping costs $45.00
200 μL
local_shipping Shipping to: United States
Available

anti-MPL antibody (Myeloproliferative Leukemia Virus Oncogene) (AA 615-628) Primary Antibody

MPL Reactivity: Human IHC, IP, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5617902
$1,150.89
Plus shipping costs $45.00
200 μg
local_shipping Shipping to: United States
Delivery in 9 to 11 Business Days
  • Type Primary
    • Primary
  • Target Myeloproliferative Leukemia Virus Oncogene (MPL)
    • Myeloproliferative Leukemia Virus Oncogene (MPL)
    • Histone 3 (H3)
    • Epidermal Growth Factor Receptor (EGFR)
    • Tumor Protein P53 (TP53)
    • Mast/stem Cell Growth Factor Receptor (KIT)
    • Protein tyrosine Phosphatase, Receptor Type, C (PTPRC)
    • tau Protein
    • CD4
    • Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2)
    • Tumor Necrosis Factor alpha (TNF alpha)
    • V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1)
    • Estrogen Receptor 1 (ESR1)
    • Interferon gamma (IFNG)
    • Nuclear Factor-kB p65 (NFkBP65)
    • V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1)
    • BCL2-Associated Agonist of Cell Death (BAD)
    • Albumin (ALB)
    • B-Cell CLL/lymphoma 2 (BCL2)
    • Tuberous Sclerosis 2 (TSC2)
    • CD19 Molecule (CD19)
    • CD8a Molecule (CD8A)
    • Hemagglutinin (HA)
    • Platelet/endothelial Cell Adhesion Molecule (PECAM1)
    • Jun Proto-Oncogene (JUN)
    • Integrin alpha M (ITGAM)
    • CD3 epsilon (CD3E)
    • Myc Proto-Oncogene protein (MYC)
    • CD44
    • Histone H4
    • Interleukin 6 (IL6)
    • Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1)
    • CD8
    • Interleukin 2 Receptor, alpha (IL2RA)
    • Vimentin (VIM)
    • C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)
    • VEGF Receptor 2 (VEGFR2)
    • Interleukin 2 (IL2)
    • Tuberous Sclerosis 1 (TSC1)
    • Amyloid beta (A4) Precursor Protein (APP)
    • CD5
    • Insulin Receptor Substrate 1 (IRS1)
    • Epithelial Cell Adhesion Molecule (EPCAM)
    • CD3
    • Glial Fibrillary Acidic Protein (GFAP)
    • CD34
    • Mucin 1 (MUC1)
    • PTK2 Protein tyrosine Kinase 2 (PTK2)
    • Catenin, beta (CATNB)
    • Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1)
    • Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1)
    • Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1)
  • Application
    • Flow Cytometry (FACS)
    • Western Blotting (WB)
    • ELISA
    • Immunofluorescence (Cultured Cells) (IF (cc))
    • Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    • Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    • Immunohistochemistry (Frozen Sections) (IHC (fro))
    • Immunohistochemistry (IHC)
    • Immunoprecipitation (IP)
    • Immunocytochemistry (ICC)
    • Enzyme Immunoassay (EIA)
    • Immunofluorescence (fixed cells) (IF/ICC)
  • Reactivity
    • Human
    • Mouse
    • Rat
    • Hamster
    • Monkey
  • Cited in publications
  • Images available
  • Preservative free only
  • Host
    • Rabbit
    • Mouse
  • Clonality
    • Polyclonal
    • Monoclonal
  • Clone
    • 1H2
    • 11D72
    • 1D6B7
    • RB56766
    • RB57635
  • Binding Specificity
    • AA 401-500
    • AA 26-491
    • AA 1-635
    • AA 615-628
    • Internal Region
    • AA 133-166
    • AA 25-423
    • AA 26-175
    • AA 311-460
    • AA 321-370
    • AA 514-546
    • AA 66-260
    • C-Term
    • pTyr626
  • Conjugate
    • Un-conjugated
    • PE
    • Biotin
    • FITC
    • HRP
    • Alexa Fluor 350
    • Alexa Fluor 488
    • Alexa Fluor 555
    • Alexa Fluor 594
    • Alexa Fluor 647
    • Alexa Fluor 680
    • Alexa Fluor 750
    • Cy3
    • Cy5
    • Cy5.5
    • Cy7
  • Isotype
    • IgG
    • IgG2a
    • Ig Fraction
    • IgG2b
  • Format
    • Liquid

MPL Antigen Profile

Protein Summary

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Alternative names and synonyms associated with MPL

  • MPL proto-oncogene, thrombopoietin receptor (MPL) antibody
  • myeloproliferative leukemia virus oncogene (Mpl) antibody
  • MPL proto-oncogene, thrombopoietin receptor (Mpl) antibody
  • MPL proto-oncogene, thrombopoietin receptor (mpl) antibody
  • c-mpl antibody
  • c-mpl-I antibody
  • c-mpl-II antibody
  • CD110 antibody
  • hlb219 antibody
  • MPL antibody
  • mpll antibody
  • MPLV antibody
  • THCYT2 antibody
  • TPO-R antibody
  • tpor antibody
  • tpor.b antibody

Protein level used designations for MPL

TPO-R , myeloproliferative leukemia protein , proto-oncogene c-Mpl , thrombopoietin receptor , myeloproliferative leukemia virus oncogene , thrombopoietin receptor-like , cytokine receptor , myeloproliferative leukemia virus oncogene, like , thrombopoietin receptor c-mpl

GENE ID SPECIES
4352 Homo sapiens
17480 Mus musculus
366455 Rattus norvegicus
414804 Gallus gallus
528492 Bos taurus
723813 Macaca mulatta
747522 Pan troglodytes
100066544 Equus caballus
100230798 Taeniopygia guttata
100355135 Oryctolagus cuniculus
100448006 Pongo abelii
100626347 Sus scrofa
445381 Danio rerio

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