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Human PIAS1 Protein expressed in Wheat germ - ABIN1314985
Chen, Hsu, Ma, Tai, Lee: CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
these results indicate that PIAS1 is a positive regulator of MYC (show MYC Proteins).
PIAS1 overexpression exacerbated mutant Huntingtin-associated phenotypes and aberrant protein accumulation
Pias1 expression in primary myoblasts enhances the induction of cardiac muscle genes MyoD (show MYOD1 Proteins), Myogenin (show MYOG Proteins) and Myomaker. Endothelial cell specific inactivation of Pias1 in vivo impairs yolk sac (show ADCY10 Proteins) erythrogenesis, angiogenesis and recapitulates loss of myocardium muscle mass. Pias1 is an essential gene for YS erythropoiesis and vasculogenesis in vivo.
Data suggest overexpression of Pias1 in white adipose tissue (WAT) of obesity/prediabetes improves insulin (show INS Proteins) resistance; knockdown of Pias1 in normal WAT leads to insulin (show INS Proteins) resistance; Pias1 expression in WAT is down-regulated by c-Jun N-terminal kinase.
Between the E3 SUMO ligase PIAS1 and STAT-3 (show STAT3 Proteins).
Knockdown of PIAS1 in astrocytes impairs the accumulation of nuclear STI1 (show STIP1 Proteins) in response to irradiation. Moreover, a PIAS1 mutant lacking the STI1 (show STIP1 Proteins) binding site is unable to increase STI1 (show STIP1 Proteins) nuclear retention.
A novel role of PIAS1 in maintaining the quiescence of dormant hematopoietic stem cells and in the epigenetic repression of the myeloerythroid program.
The present study showed that PIAS1 functions as a SUMO E3 ligase of C/EBPbeta (show CEBPB Proteins) to regulate adipogenesis.
Piasy (show PIAS4 Proteins) represses the synergistic activation of PITX2 (show PITX2 Proteins) with interacting co-factors and Piasy (show PIAS4 Proteins) represses Pias1 activation of PITX2 (show PITX2 Proteins) transcriptional activity.
MAPK-activated protein kinase-2 limits endothelial inflammation via the PIAS1 S522 phosphorylation-mediated increase in PIAS1 transrepression and SUMO ligase activity.
PIAS1 is a prognostic biomarker in breast cancer
PIAS1 is a determinant of poor survival and acts as a positive feedback regulator of AR signaling through enhanced AR stabilization in prostate cancer
HBs protein-induced hPIAS1 transcription requires TAL1 (show TAL1 Proteins), E47 (show TCF3 Proteins), MYOG (show MYOG Proteins), NFI (show NFIC Proteins), and MAPK (show MAPK1 Proteins) signal pathways
identified the SUMO ligase PIAS1 as a constituent PML (show PML Proteins)-NB antiviral protein. This finding distinguishes a SUMO ligase that may mediate signaling events important in promyelocytic leukemia (show PML Proteins) nuclear body mediated intrinsic immunity.
PIAS1 enhances p300 (show EP300 Proteins) recruitment to c-Myb (show MYB Proteins)-bound sites through interaction with both proteins. In addition, the E3 activity of PIAS1 enhances further its coactivation
Results show that apocrine breast cancer and prostate cancer cells share a core AR cistrome and target gene signature linked to cancer cell growth, and PIAS1 plays a similar coregulatory role for AR in both cancer cell types.
c-Myc (show MYC Proteins) is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 (show SENP7 Proteins) and RNF4 (show RNF4 Proteins)
Data demonstrate that PIAS1 interacts with TRF2 (show TERF2 Proteins) and mediates its sumoylation serving as a molecular switch that controls the level of TRF2 (show TERF2 Proteins) at telomeres.
This gene encodes a member of the mammalian PIAS
protein inhibitor of activated STAT, 1
, DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1
, DEAD/H box-binding protein 1
, E3 SUMO-protein ligase PIAS1
, protein inhibitor of activated STAT protein 1
, AR interacting protein
, RNA helicase II-binding protein
, gu-binding protein
, protein inhibitor of activated STAT-1
, zinc finger, MIZ-type containing 3
, SUMO E3 ligase