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anti-Mouse (Murine) Serotonin Receptor 2B Antibodies:
anti-Human Serotonin Receptor 2B Antibodies:
anti-Rat (Rattus) Serotonin Receptor 2B Antibodies:
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Human Polyclonal Serotonin Receptor 2B Primary Antibody for ICC, IF - ABIN4890720
Lee, Cho, Tonello, Lee, Jang, Park, Hwang, Park, Jung, Berta: Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice. in The Journal of allergy and clinical immunology 2018
Human Polyclonal Serotonin Receptor 2B Primary Antibody for IHC, IHC (p) - ABIN4276881
De Sousa E Melo, Wang, Jansen, Fessler, Trinh, de Rooij, de Jong, de Boer, van Leersum, Bijlsma, Rodermond, van der Heijden, van Noesel, Tuynman, Dekker, Markowetz, Medema, Vermeulen: Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. in Nature medicine 2013
Human Polyclonal Serotonin Receptor 2B Primary Antibody for IHC (p) - ABIN270524
Assetta, Morris-Love, Gee, Atkinson, OHara, Maginnis, Haley, Atwood: Genetic and Functional Dissection of the Role of Individual 5-HT2 Receptors as Entry Receptors for JC Polyomavirus. in Cell reports 2019
5-HT(2) receptors are coupled to phospholipase C in bovine ciliary epithelium.
these observations indicate that the 5-HT2B receptor acts as a direct positive modulator of serotonin Pet1-positive neurons in an opposite way as the known 5-HT1A negative autoreceptor.
Our results indicate that prolonged Htr2b activation in murine beta-cells decreases glucose-stimulated insulin secretion and mitochondrial activity by mechanisms likely dependent on enhanced PGC1a/PPARygexpression.
heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively.
Activation of 5-HT2B receptors stimulates GSIS in beta cells by triggering downstream changes in cellular Ca(2+) flux that enhance mitochondrial metabolism.
Heritable pulmonary arterial hypertension (PAH) results from increased SRC activation, cellular contraction, and vascular resistance, but antagonism of HTR2B prevents SRC phosphorylation and development of PAH.
Results support that the abnormal organization of retinal projections in Htr2B-/- animals is due to the lack of 5-HT activation of 5-HT2B receptors in postnatal microglial cells
5HT2BR-mediated signaling pathways are involved in enamel formation and dentinogenesis
5-HT2B stimulation has no effectin neurite outgrowth.
the serotonin transporter has a role in regulating clearance of apoptotic cells through neuroendocrine signaling
Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR-ss/delta in osteoblasts.
the results suggested that RKT improves the decrease in food intake after novelty stress probably via 5-HT(2B) receptor antagonism of isoliquiritigenin contained in RKT.
Augmented contractile properties of arteries in a model of type 2 diabetes mellitus are not due to changes in 5HT(2A)/5HT(2B) receptors.
Thermal unfolding of the 5-hydroxytryptamine receptors occurred in consecutive steps at distinct protein locations
5-HT(2B) R [deficiency] interferes with the mechanisms directing amelogenesis
Activation of 5-HT(2B) receptors on bone marrow lineage progenitors is critical for the development of pulmonary arterial hypertension.
5-HT2B blockade enhances liver regeneration by inhibiting induction of TGF-beta1 expression by hepatic stellate cells that is dependent on 5-HT, ERK and JunD.
The results of this study suggest a significant role of 5-HT(2A)R and 5-HT(2B)R in respiratory network modulation.
Data suggest that transgenic mice without 5HT2B receptors are more prone to develop 5HT syndrome; further, data suggest that the presence of 5HT2B receptors hinders acute 5HT toxicity once high levels of 5HT are attained.
Knockout of Htr2b increased impulsive behaviours in mice
Once the HT2B receptor is expressed, it constitutively controls tissue-nonspecific alkaline phosphatase activity at a post-translational level along the overall period of bone mineral deposition
In humans, mitral valve prolapse is associated with an upregulation in 5HTR2B expression and increased 5HT receptor signaling in the leaflets.
findings support a role for the serotonin receptor 2B in the proliferation and migration of uveal melanoma cells, through activation of many signaling pathways such as WNT, Focal adhesion kinase and Janus kinase/STAT
HTR2B transcription is regulated by NFI and RUNX1 in uveal melanoma cells.
The biological role of 5-HT2B which may act not only as a neurotransmitter receptor.
The 3.0-A resolution structure of a complex between the human 5-hydroxytryptamine 2B (5-HT2B) receptor and an antibody Fab fragment bound to the extracellular side of the receptor reveals the mechanism of selectivity in extracellular recognition of the receptor by monoclonal antibodies.
These findings suggest that 5-HT promotes CCN2 production through the 5-HT2AR in growth plates, and that it represses CCN2 production through the 5-HT2BR in articular cartilage for harmonized development of long bones
MFSD2B, CCL20 and STAT1, or STARD7 and ZNF512 genes may be risk or protect factors in prognosis of ADC; HTR2B, DPP4, and TGFBRAP1 genes may be risk factors in prognosis of SQC.
The HTR2B Q20* allele and testosterone predicted lower BMI independently, but an interaction between HTR2B Q20* and testosterone lead to increased insulin sensitivity among HTR2B Q20* carriers with low testosterone levels.
Study describes the crystal structure of Lysergic acid diethylamide (LSD) in complex with the human serotonin receptor 5-HT2B. The complex reveals conformational rearrangements to accommodate LSD, providing a structural explanation for the conformational selectivity of LSD's key diethylamide moiety.
The 5-HT2B receptor may contribute to the regulation of human glucagon and glucose homeostasis and the interplay between glucagon and insulin secretion.
Authors hypothesize that HTR2B expression in the infarcted territory may render degenerating neurons susceptible to attack by activated microglia and thus aggravate the consequences of stroke.
the 5-HT2B receptor limits degeneration of spinal cord mononuclear phagocytes, most likely microglia, and slows disease progression in amyotrophic lateral sclerosis
Studies have found that the HTR2B Q20* connected with impulsive behavior and cognitive impulsivity.
Data indicate that hydrogen bonding interactions with Ser3.36 and Thr3.37 were important for isoflurane binding with the 5HT2B receptor.
results of the present study suggest that the HTR2B polymorphism is not likely to be associated with personality traits, including novelty seeking and impulsivity.
Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-HT2 receptors.
a new and unanticipated role of the 5-HT2B receptor N terminus as a negative modulator, affecting both constitutive and agonist-stimulated activity.
5-HT2AR, 5-HT2BR, and 5-HT2CR expression in HEK293A cells significantly increases susceptibility to JCPyV infection
distribution of serotonin 2B receptor is species different in the pig small intestine and the intensity of serotonin 2B receptor becomes stronger as the small intestine matures
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.
5-hydroxytryptamine (serotonin) receptor 2B
, 5-hydroxytryptamin receptor
, 5-hydroxytryptamine receptor 2B
, 5HT2B receptor
, serotonin receptor 2B
, 5-hydroxytryptamine receptor 2B-like
, NP75 protein
, 5-HT2B serotonin receptor
, 5-HT 2B receptor
, 5-hydroxytryptamine 2B receptor
, 5-hydroxytryptamine receptor 2B variant b
, stomach fundus serotonin receptor
, serotonin 2B receptor