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anti-Mouse (Murine) Serotonin Receptor 6 Antibodies:
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Intracellular 5-hydroxytryptamine receptors (5-HT6R) signaling was found to be linked to RhoA GTPase activation and was involved in the maturation of osteoclasts. This signaling pathway also showed enhanced bone destruction after lipopolysaccharide (LPS) administration in mice.
Results suggest that degeneration of the nigrostriatal pathway causes the decreased dopamine levels in the limbic and limbic related brain regions and the enhanced sensitivity of the 5-HT6 receptor on the glutamate and GABA neurons in the basolateral amygdala, which appear to be an etiologic and pathophysiological factor for anxiety in Parkinson's disease.
High 5-HT6R expression is associated with delayed bone development and regeneration.
This study suggested that 5-HT6 plays a critical role in Alzheimer's disease development through regulating the morphology and function of neuronal primary cilia, which is possibly related to the AIS and axon alterations in Alzheimer's disease development.
these findings suggest that disrupting 5-HT6 receptor-neurofibromin interaction prevents agonist-independent 5-HT6 receptor-operated cAMP signaling in prefrontal cortex, an effect that might underlie neuronal abnormalities in NF1 patients.
Results implicate a role of 5-HT6 receptor signaling in primary cilia morphology, suggest that 5-HT6 receptor research should consider relative levels of receptor expression when evaluating their impact on primary cilia function.
5-HT6/7 receptor antagonist ADN-1184 displays anxiolytic-like activity in animal models of anxiety which employed punished stimuli.
SNX14 is a dual endogenous negative regulator in 5-HT6R-mediated signaling pathway.
Constitutive expression of 5-HT6R controls pyramidal neuron migration through an agonist-independent mechanism that requires Cdk5 activity.
Knockdown of MAO-A expression in embryos induces high serotonin levels and abnormal brain development, which can be rescued by inactivation of serotonin receptor-6.
Coexpression of 5HT6 with adenylyl cyclase type III normalizes cilia structure and restores dendrite outgrowth.
Serotonergic stimulation of 5-HT6 serotonin receptors augments extrapyramidal motor symptoms; antagonism of 5-HT6 receptors alleviates the symptoms.
5-HT6 receptors were expressed in embryonic mouse cortical interneurons and that 5-HT6 receptor activation decreased interneuron migration, whereas 5-HT6 receptor blockade prevented the migratory effects induced by 5-HT.
Serotonin 6 receptor has a role in Alzheimer's disease and depression
that HTR6 plays an important role in modulating seizure activity and that the blockade of the 5-HT6 receptor/mTOR pathway could be a potential therapeutic target for epilepsy treatment
Studies indicate that serotonin 5-HT6 receptor (5-HT6R) has been proposed as a promising drug target for cognition enhancement in Alzheimer's disease (AD).
[review] Controlling the activity of 5-HTR6 receptors seems to provide benefits by alleviating cognitive impairments.
Data indicate that hydrogen-bond formation of a methoxy or hydroxy group is not important for binding at the 5-HT6 receptor.
The human cloned 5-HT6 receptor is stably transfected in HeLa cells.
When expressed in pyramidal neuron progenitors, serotonin receptor 5-HT6 transgene decreases the migration speed of cortical pyramidal neurons, thereby affecting a fundamental step in the assembly of neural circuits.
These observations suggest that recruitment of mTOR by prefrontal 5-HT(6) receptors contributes to the perturbed cognition in schizophrenia, offering new vistas for its therapeutic control.
There was a statistically significant difference in semantic memory scores among the three genotype groups of T267C in 5-HT6.
present findings showed the presence of a higher density of 5-HT(6) receptors, as labeled by [(125)I]SB-258585, in striatum than in hippocampus and prefrontal cortex, and specifically within the neuronal body
results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia.
[review] Since discovery of the 5-HT6 receptor and development of its small-molecule ligands, neurochemical and localization studies have clearly demonstrated its central role in modulating GABAergic neurotransmission across brain structures and networks.
detected association between 2 markers (rs6693503 and rs1805054) and three markers (rs6693503, rs1805054 and rs4912138) in HTR6 and METH-induced psychosis respectively. HTR6 may play important role in pathophysiology of METH-induced psychosis in Japanese
Common variants in the gene for HT6R do not contribute to obesity.
we found no association involving HTR6 polymorphism and mood disorder in the Japanese population
Data show that analogues of 5-cyclic amine-3-arylsulfonylindazoles have been identified as high-affinity 5-HT(6) receptor ligands.
Jab1 provides a novel signal transduction pathway for 5-HT(6)R and may play an important role in 5-HT(6)R-mediated behavior changes in the brain
SNP might have a role in the etiology of suicide in male subjects in the Portuguese population.
5-HT6 receptor gene polymorphism C267T is associated with Parkinson's disease.
Association of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease. apolipoprotein E epsilon 4 status. the 267C allele of the 5-HT(6) receptor gene may not be a genetic risk factor for AD.
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity).
, 5-hydroxytryptamine receptor 6
, serotonin receptor 6
, 5-alpha-hydroxytryptamine receptor 6