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Human STAT3 Protein expressed in Wheat germ - ABIN1321594
Qian, Chai, Liang, Wang, Zhou, Xu, Zhang, Zhang, Si, Huang, Huang, Hong, Wang: KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer. in Molecular cancer 2014
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Study in mouse psoriasis model suggests that Stat3 activation in keratinocytes may impact on Langerhans cell activation in situ via IL-1alpha stimulation, at least in part, and that their presence may be essential for the pathogenesis of psoriasis through producing IL-23.
The RNF20-mediated H2Bub1 cooperating with MOF-mediated H4K16ac activates the transcription of Stat3
MiR-125a-3p exerts anti-fibrotic effects in silica-induced pulmonary fibrosis by regulating Fyn/STAT3 signaling.
IL-23 signaled through both STAT3 and STAT4, and disruption in STAT4 signaling impaired CNS autoimmunity independent of IL-12
These results indicate that Stat3 is indispensable for the survival of epithelial cells through the activation of integrin signaling and the downstream FAK pathway; however, it is not required for the Wnt signaling-activated normal or tumor epithelial cells.
Here the authors show that the transcription factor Stat3, a canonical inducer of astrogliosis, is activated in an Alzheimer's disease mouse model and human Alzheimer's disease. Therefore, using a conditional knockout approach, the authors deleted Stat3 specifically in astrocytes in the APP/PS1 model of Alzheimer's disease. They found that Stat3-deficient APP/PS1 mice show decreased beta-amyloid levels and plaque burden.
High STAT3 expression is associated with renal dysfunction, inflammation and fibrosis in Alport syndrome.
Cucurbitacin E ameliorates acute graft-versus-host disease by modulating Th17 cell subsets and inhibiting STAT3 activation.
BATF2 activates DUSP2 gene expression and up-regulates NF-kappaB activity via phospho-STAT3 dephosphorylation
These findings imply that regionally distinct patterns of STAT3 phosphorylation in the Sertoli cells depend on either location or spermatogenic activity in normal healthy testes in vivo, highlighting a novel entry point to understanding STAT signaling in mammalian spermatogenesis.
this study demonstrates a previously unrecognized protective role of myeloid cell-specific STAT3 signaling in immune cell-mediated skin fibrosis
Studied effect of Papaver nudicaule extract on reduction of inflammation through inactivating NF-kappaB and signal transducer and activator of transcription 3 (STAT3) in lipopolysaccharide treated RAW264.7 cells.
Study provides evidence that Stat3 activity is required for HC11 mammary epithelial cell differentiation.
PRMT1 thus regulates Th17 differentiation by controlling the reciprocal recruitment of STAT3 and STAT5.
Findings indicate excess signal transducer and activator of transcription 3 (STAT3) activity negatively regulated preproopiomelanocortin (POMC) expression in hypothalamus of diet induced obesity (DIO) mice.
Results indicate that dopamine receptor D5 (DRD5)-signalling in dendritic cells (DCs) was mediated through the attenuation of signal transducer and activator of transcription 3 (STAT3)-activation.
Study identified Fam3a, a cytokine-like protein, as a major Stat3 downstream effector in muscle stem cells and demonstrated that Fam3a is required for muscle stem cell commitment and skeletal muscle development. These findings indicate that Fam3a is a Stat3-regulated secreted factor that promotes muscle stem cell oxidative metabolism and differentiation.
miR-151-3p inhibited lipopolysaccharide-induced IL-6 production by targeting Stat3.
DLX3 is a critical regulator of STAT3 signaling network that maintains skin homeostasis.
Stat3 conditional knockout adult mice were significantly resistant to collagen-induced arthritis.
The miR-1181/STAT3 axis mediated PDGFBB-induced dysfunction in human PASMCs.
STAT3 protein expression is upregulated in human papillary thyroid cancers (PTC) and in thyroid carcinoma cell lines exposed to PLX4032, a BRAF inhibitor, inducing PTC resistance.
Data show that phosphorylated STAT3 could bind to the miR155HG promoter region from - 1548 bp to - 1411 bp upstream of the transcription start site to stimulate miR155HG expression. This suggests that STAT3 phosphorylation is the critical role in driving lncRNAs regulation similar to miR155HG in malignant brain tumor.
Hsa_circ_0068871 regulates the miR-181a-5p/FGFR3 axis and activates STAT3 to promote bladder cancer (BCa) progression, and it may serve as a potential biomarker.
The present results revealed that the JAK3/STAT3 oncogenic pathway and PRDM1 expression could stratify clinicopathologic features of extranodal NK/Tcell lymphoma, nasal type (ENNK/TNT).
the intracellular interaction of IL-32theta;, PKCdelta, and STAT3 to regulate IL-13 and IL-13Ralpha2 synthesis, supporting the role of IL-32theta; as an inflammatory modulator.
The data point to a participation of Notch in stabilizing toll like receptor-mediated STAT3 activation and STAT3-mediated modulation of myeloid functional phenotype through induction of immune-suppressive PD-L1.
STAT3 participates in modulating G2-M phase checkpoint by regulating gene expressions of cyclin B1 and Cdc2 via E2F.
A significant positive correlation was demonstrated between STAT1 and STAT2 and also between STAT1 and STAT3.
a functional role of ASS1 in HCC. Overexpression of ASS1 inhibits HCC progression by inactivating the pSTAT3Ser727 pathway, which subsequently decreases the expression of ID1.
There is a strong link between pri-miR-124-1 rs531564 and STAT3 rs1053023 and gastric cancer that may be pathogenic, and so worthy of further investigation.
A significant increase was observed in expression of STAT3 and lnc-DC genes but not SOCS1 in coronary artery disease \+ versus coronary artery disease- patients.
Study shows that high expression of IL22RA1 is associated with poor prognosis in pancreatic cancer. IL22 promotes pancreatic cancer stemness via IL22RA1/STAT3 signaling, identifying the mechanism of regulation of cancer stem cells by microenvironmental factors. Moreover, STAT3 activation is indispensable for the maintenance of IL22RA1-hi cells, both in the absence or presence of IL22.
these data indicate that miR-124 suppresses the growth and invasion of breast cancer cells via downregulation of STAT3 expression.
We further demonstrate that RIP4-activated STAT3 binds CCL20 promoter region and regulates its expression.
In extranodal NK/T-cell lymphoma, STAT3 activation correlated significantly with PD-L1 expression.
IFN-beta, by virtue of its activating the IDO/Kyn/AhR cascade and serine phosphorylation of STAT3, induces dormancy of melanoma tumor-repopulating cells
Study that STAT3 expression is regulated in colorectal neoplasm by PTPN4 which directly dephosphorylates pSTAT3 at the Tyr705 residue and suppresses its transcriptional activity.
SOCS3 overexpression rescued the IL-9-induced effects. Altogether, IL-9 participates in the pathogenesis of Ulcerative colitis (UC) through STAT3/SOCS3 signaling pathway and has the potential to serve as a possible therapeutic candidate in patients with UC
LncRNA PTCSC3 was low-expressed in anaplastic thyroid cancer (ATC) tissues and cells. Over-expressed PTCSC3 inhibited the drug resistance of ATC to doxorubicin. PTCSC3 negatively regulated STAT3, and STAT3 promoted expression of INO80. PTCSC3 regulated INO80 through STAT3. PTCSC3 suppressed stem cells properties and drug resistance of ATC to doxorubicin.
variations in the STAT3 gene promoter regions, most notably haplotype H3H3, may benefit marker-assisted breeding of Qinchuan cattle.
Thus, activation of STAT3 and inactivation of AKT signaling are involved in structural regression of the corpus luteum.
STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes
role of shear flow in attenuating activation in endothelial cells
peroxynitrite causes increased expression of VEGF in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase-mediated activation of STAT3.
STAT3tyr705 phosphorylation/total STAT3 protein at early reperfusion significantly increased by ischemic preconditioning
In porcine circovirus type 2 subclinical infection, SOCS3 interacted with STAT3 and TNF receptor-associated factor 2, suggesting mechanisms by which SOCS3 inhibits IL-6 and TNF-alpha signaling.
this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF-supplemented media.
Data suggest that IL-6 (interleukin 6) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
Osteoarthritis-cartilage injuries are caused by activating JAK2/STAT3 pathway.
This is the first report of the genetic polymorphisms of the JAK1 and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
Stat3 is required for hepatocyte cell differentiation and liver regeneration.
Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a expression during oogenesis. Accordingly, restoring Cdc25a expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
PTPN9 plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 and ZBP-89.
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3