STAT3 Protein (His tag)
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- Target See all STAT3 Proteins
- STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This STAT3 protein is labelled with His tag.
- Purpose
- Recombinant Human STAT3 Protein (His Tag)
- Sequence
- Met 1-Asn175
- Characteristics
- Recombinant Human Signal Transducer and Activator of Transcription 3 is produced by our E.coli expression system and the target gene encoding Met1-Asn175 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product STAT3 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
- Alternative Name
- STAT3 (STAT3 Products)
- Synonyms
- 1110034C02Rik Protein, AW109958 Protein, Aprf Protein, APRF Protein, HIES Protein, Xstat3 Protein, aprf Protein, hies Protein, stat3 Protein, wu:fc15d02 Protein, wu:fl59g06 Protein, z-Stat3 Protein, signal transducer and activator of transcription 3 Protein, signal transduction and activation of transcription 3 Protein, signal transducer and activator of transcription 3, gene 1 L homeolog Protein, signal transducer and activator of transcription 3 (acute-phase response factor) Protein, STAT3 Protein, stat3 Protein, Stat3 Protein, stat3.1.L Protein
- Background
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Background: Signal Transducer and Activator of Transcription 3 (STAT3) belongs to the transcription factor STAT family. STAT3 contains one SH2 domain and is a transcription factor expressed in most cell types. STAT3 is activated by multiple cytokines and growth factors including: IFN-a, IL-10, IL-6, IL-11, IL-12, IL-2, EGF etc. STAT3 functions as signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. In addition, STAT3 may also mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Synonym: Signal Transducer and Activator of Transcription 3, Acute-Phase Response Factor, STAT3, APRF
- Molecular Weight
- 21.8 kDa
- UniProt
- P40763
- Pathways
- JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor
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