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anti-Human STAT4 Antibodies:
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Human Monoclonal STAT4 Primary Antibody for ICS - ABIN1177203
Kisseleva, Bhattacharya, Braunstein, Schindler: Signaling through the JAK/STAT pathway, recent advances and future challenges. in Gene 2002
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Human Monoclonal STAT4 Primary Antibody for ICS - ABIN1177204
Visconti, Gadina, Chiariello, Chen, Stancato, Gutkind, OShea: Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. in Blood 2000
Show all 2 Pubmed References
Human Polyclonal STAT4 Primary Antibody for IHC, WB - ABIN362570
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 2 Pubmed References
Dog (Canine) Polyclonal STAT4 Primary Antibody for IHC, WB - ABIN2777897
Torpey, Maher, Bothwell, Pober: Interferon alpha but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells. in The Journal of biological chemistry 2004
Human Polyclonal STAT4 Primary Antibody for ELISA, WB - ABIN4356388
Good, Thieu, Mathur, Yu, Stritesky, Yeh, OMalley, Perumal, Kaplan: Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming. in Journal of immunology (Baltimore, Md. : 1950) 2009
No significant associations between STAT4 variant and serum neopterin or disease activity parameters were identified. The study confirmed the association of STAT4 rs7574865 polymorphism with rheumatoid arthritis and was the first to indicate an association with rheumatoid factor and anti-cyclic citrullinated peptide antibodies positivity.
5 STAT4 SNPs were tested in 233 patients with established NMOSD and 492 healthy controls. Allelic, additive, dominant, and recessive models identified associations with NMOSD. Minor alleles of 4 STAT4 SNPs exhibited significant association with increased risk of NMOSD: rs7574865 T; rs10181656 G; rs10168266 T; and rs13426947 A in all models. rs7601754 G displayed a protective effect against NMOSD.
data demonstrate that STAT4 plays a role in enabling the normal and timely division of cells undergoing mitosis
rs744166GG in STAT3 (show STAT3 Antibodies) and rs7574865TT in STAT4 had higher frequencies in the case than the control group, suggesting these 2 genotypes increase the susceptibility to psoriasis ( p < 0.05).
Genome-wide association study identified a locus in STAT4, rs13390936, associated with nontyphoidal Salmonella bacteremia.
Neither alleles nor genotypes of rs7601754 SNP of STAT4 gene demonstrated associations with juvenile rheumatoid arthritis (JRA). We recognize that gene variants of STAT4 did not affect JRA susceptibility in an Iranian population.
genetic association studies in population in southwest China: Data suggest that SNPs in STAT4 (rs7574865), IL23R (show IL23R Antibodies) (rs11209032), and STAT3 (show STAT3 Antibodies) (rs744166) are associated with occurrence, severity, and immunosuppressive therapy outcomes of aplastic anemia in the population studied. (IL23R (show IL23R Antibodies) = interleukin 23 receptor (show IL23R Antibodies)) [article includes Meta-Analysis]
STAT4 is a novel transcriptional regulator of p66Shc (show SHC1 Antibodies) in normal and chronic lymphocytic leukemia B cells
IL13 (show IL13 Antibodies) AA of rs20541 and STAT4 TT of rs925847 are potential genomic biomarkers for predicting lower pulmonary function. The administration of high-dose ICSs to asthmatic patients with genetic variants of IL13 (show IL13 Antibodies) AA may inhibit the advancement of airway remodelling. The genetic variants of STAT4 TT did not respond to high-dose ICSs.
STAT4 mRNA expression was significantly correlated with IFNG (show IFNG Antibodies) mRNA expression.
The results show that STAT4 plays a critical role in mediating both Th1 (show HAND1 Antibodies) and Th2 responses upon immunization with monophosphoryl lipid A.
this study shows that STAT4 regulates the CD8 (show CD8A Antibodies)(+) regulatory T cell/T follicular helper cell axis and promotes atherogenesis in insulin (show INS Antibodies)-resistant Ldlr (show LDLR Antibodies)(-/-) mice
virus-specific effector and memory CD4 (show CD4 Antibodies) T cells formed independently of Tbet and STAT4, although a slight reduction in the number of antigen-specific CD4 (show CD4 Antibodies) T cells was apparent in mice lacking both transcription factors.
STAT4 has a pro-atherogenic role that is at least partially independent of Th1 (show HAND1 Antibodies) cell-derived interferon-gamma (show IFNG Antibodies)
Modulation of IL-12 (show IL12A Antibodies)/STAT4 signaling may be a valuable therapeutic strategy to preserve islet/beta-cell viability in established diabetes
This study found that stathmin (show STMN1 Antibodies) plays an important role in adult hippocampal neurogenesis and spinogenesis. In addition, stathmin (show STMN1 Antibodies) mutation led to impaired NMDA receptor-dependent and neurogenesis-associated memory
STAT4 controls GM-CSF (show CSF2 Antibodies) production by both Th1 (show HAND1 Antibodies) and Th17 cells during experimental autoimmune encephalomyelitis.
Data (including data from studies in knockout mice) suggest Stat4 deletion reduces inflammation in peri (show POSTN Antibodies)-vascular and visceral adipose tissue and this appears to contribute via direct or indirect effects to reduced atheroma formation.
T-bet- and STAT4-dependent IL-33 (show IL33 Antibodies) receptor expression have roles in directly promoting antiviral Th1 (show HAND1 Antibodies) cell responses
Primary infections of mice with lymphocytic choriomeningitis virus (LCMV) demonstrated that T cell receptor stimulation induced responsiveness for IFN-gamma (show IFNG Antibodies) and CD25 (show IL2RA Antibodies) induction through STAT4-independent pathways.
These results suggest that the 2 single nucleotide polymorphisms of STAT4 could be used as genetic markers for milk performance traits in Chinese Holstein cows.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
signal transducer and activator of transcription 4