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anti-Human STAT4 Antibodies:
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Human Monoclonal STAT4 Primary Antibody for ICS - ABIN1177203
Kisseleva, Bhattacharya, Braunstein, Schindler: Signaling through the JAK/STAT pathway, recent advances and future challenges. in Gene 2002
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Human Monoclonal STAT4 Primary Antibody for ICS - ABIN1177202
Visconti, Gadina, Chiariello, Chen, Stancato, Gutkind, OShea: Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. in Blood 2000
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Human Polyclonal STAT4 Primary Antibody for IHC, WB - ABIN362570
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
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Polyclonal STAT4 Primary Antibody for DB, IHC (fro) - ABIN541072
Miyagi, Gil, Wang, Louten, Chu, Biron: High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells. in The Journal of experimental medicine 2007
Dog (Canine) Polyclonal STAT4 Primary Antibody for IHC, WB - ABIN2777897
Torpey, Maher, Bothwell, Pober: Interferon alpha but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells. in The Journal of biological chemistry 2004
Human Polyclonal STAT4 Primary Antibody for ELISA, WB - ABIN4356388
Good, Thieu, Mathur, Yu, Stritesky, Yeh, OMalley, Perumal, Kaplan: Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming. in Journal of immunology (Baltimore, Md. : 1950) 2009
Human Polyclonal STAT4 Primary Antibody for IHC, IP - ABIN6711908
Guo, Li, Zhao, Fan, Hu, Hou: Glucocorticoid receptor mediates the effect of progesterone on uterine natural killer cells. in American journal of reproductive immunology (New York, N.Y. : 1989) 2012
Study provides evidence that polymorphisms of rs7574865, rs3024921, rs6752770, rs7601754 and rs10168266 in STAT4 were significantly associated with the risk of primary biliary cholangitis.
Single nucleotide polymorphisms in ITGAM, TNFSF4, TNFAIP3 and STAT4 genes are associated with susceptibility to systemic lupus erythematosus in a North Indian population.
the present study postulates that the genetic variation of the transcription factor GATA3, not STAT4, is associated with the risk of type 2 diabetes in the Bangladeshi population.
Lack of association of rs7574865 and rs7601754 SNPs in STAT4 gene with susceptibility to JSLE in Iranian population, despite their association with the risk of adult SLE in the same population, implicates on difference of genetic background of JSLE and SLE.
No significant associations between STAT4 variant and serum neopterin or disease activity parameters were identified. The study confirmed the association of STAT4 rs7574865 polymorphism with rheumatoid arthritis and was the first to indicate an association with rheumatoid factor and anti-cyclic citrullinated peptide antibodies positivity.
5 STAT4 SNPs were tested in 233 patients with established NMOSD and 492 healthy controls. Allelic, additive, dominant, and recessive models identified associations with NMOSD. Minor alleles of 4 STAT4 SNPs exhibited significant association with increased risk of NMOSD: rs7574865 T; rs10181656 G; rs10168266 T; and rs13426947 A in all models. rs7601754 G displayed a protective effect against NMOSD.
data demonstrate that STAT4 plays a role in enabling the normal and timely division of cells undergoing mitosis
rs744166GG in STAT3 and rs7574865TT in STAT4 had higher frequencies in the case than the control group, suggesting these 2 genotypes increase the susceptibility to psoriasis ( p < 0.05).
Genome-wide association study identified a locus in STAT4, rs13390936, associated with nontyphoidal Salmonella bacteremia.
Neither alleles nor genotypes of rs7601754 SNP of STAT4 gene demonstrated associations with juvenile rheumatoid arthritis (JRA). We recognize that gene variants of STAT4 did not affect JRA susceptibility in an Iranian population.
genetic association studies in population in southwest China: Data suggest that SNPs in STAT4 (rs7574865), IL23R (rs11209032), and STAT3 (rs744166) are associated with occurrence, severity, and immunosuppressive therapy outcomes of aplastic anemia in the population studied. (IL23R = interleukin 23 receptor) [article includes Meta-Analysis]
STAT4 is a novel transcriptional regulator of p66Shc in normal and chronic lymphocytic leukemia B cells
IL13 AA of rs20541 and STAT4 TT of rs925847 are potential genomic biomarkers for predicting lower pulmonary function. The administration of high-dose ICSs to asthmatic patients with genetic variants of IL13 AA may inhibit the advancement of airway remodelling. The genetic variants of STAT4 TT did not respond to high-dose ICSs.
STAT4 mRNA expression was significantly correlated with IFNG mRNA expression.
findings demonstrate that variants in STAT4 play a critical role in HBV infection and clearance in the Chinese Han population.
STAT4 rs7574865G/T polymorphism is associated with rheumatoid arthritis and systemic lupus erythematosus in Mexican women
STAT4_rs7574865 TT was associated with the presence of actively inflamed joints and extra-articular damage in patients with Juvenile Idiopathic Arthritis.
Results found that activated STAT4 was overexpressed in epithelial cells of ovarian cancer and provide evidence that it promotes ovarian cancer metastasis via tumor-derived Wnt7a-induced activation of cancer-associated fibroblasts.
STAT4 rs7574865 gene polymorphism is associated with the susceptibility of primary biliary cirrhosis in the Han population of Jiangsu province.
The findings results confirm the important role of STAT4 gene in the predisposition to Systemic sclerosis and its phenotypes, such as the presence of Interstitial Lung disease , cardiac injury , and seropositivity for anti-topoisomerase I antibodies in the Russian population.
these findings show a feed-forward mechanism involving STAT4 and T-BET that modulates the outcome of IL-23 signaling in innate lymphoid cells
The results show that STAT4 plays a critical role in mediating both Th1 and Th2 responses upon immunization with monophosphoryl lipid A.
this study shows that STAT4 regulates the CD8(+) regulatory T cell/T follicular helper cell axis and promotes atherogenesis in insulin-resistant Ldlr(-/-) mice
virus-specific effector and memory CD4 T cells formed independently of Tbet and STAT4, although a slight reduction in the number of antigen-specific CD4 T cells was apparent in mice lacking both transcription factors.
expression associated with early Inflammation in diabetic wounds
STAT4 has a pro-atherogenic role that is at least partially independent of Th1 cell-derived interferon-gamma
Modulation of IL-12/STAT4 signaling may be a valuable therapeutic strategy to preserve islet/beta-cell viability in established diabetes
This study found that stathmin plays an important role in adult hippocampal neurogenesis and spinogenesis. In addition, stathmin mutation led to impaired NMDA receptor-dependent and neurogenesis-associated memory
STAT4 controls GM-CSF production by both Th1 and Th17 cells during experimental autoimmune encephalomyelitis.
Data (including data from studies in knockout mice) suggest Stat4 deletion reduces inflammation in peri-vascular and visceral adipose tissue and this appears to contribute via direct or indirect effects to reduced atheroma formation.
T-bet- and STAT4-dependent IL-33 receptor expression have roles in directly promoting antiviral Th1 cell responses
Primary infections of mice with lymphocytic choriomeningitis virus (LCMV) demonstrated that T cell receptor stimulation induced responsiveness for IFN-gamma and CD25 induction through STAT4-independent pathways.
STAT4 appears to be a critical transcription factor in defense against mycobacterial infection
STAT4 deficiency protects against neointima formation following arterial injury in mice.
IL-12 drives small airway remodeling via STAT4 signaling.
These data demonstrate that STAT4 regulates the respiratory syncytial virus-specific CD8+ T cell response to secondary infection but does not independently regulate lung Th2 or Th17 immune responses.
TCR-induced PD-1 expression was augmented by IL-6 and IL-12, inducers of STAT3 and STAT4 activity
STAT4 is dispensable for antimonial-based chemotherapy.
We have identified STAT4 as a key contributor to insulin resistance and AT inflammation in diet-induced obesity.
STAT4 deficiency has no conspicuous effect on the development and fecundity of S. japonicum.
These results suggest that the 2 single nucleotide polymorphisms of STAT4 could be used as genetic markers for milk performance traits in Chinese Holstein cows.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
signal transducer and activator of transcription 4