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the two cell lines exhibited relatively low protein expression levels of p53 (show TP53 Proteins), lower levels of p53 (show TP53 Proteins) and TPp53BP1 transcripts were detected in the K562/G cells. Taken together, these findings suggest that the resistance of CML (show BCR Proteins) to the tyrosine kinase (show TXK Proteins) inhibitor, imatinib, may be associated with persistent STAT5-mediated ROS (show ROS1 Proteins) production, and the abnormality of the p53 (show TP53 Proteins) pathway
Peripheral blood Tregs failed to effectively utilize IL-2 (show IL2 Proteins) and had relatively little STAT5 phosphorylation in active ankylosing spondylitis.
These results indicate that IL-3 (show IL-3 Proteins) regulates endothelial cells-extracellular vesicles release, cargo and IL-3 (show IL-3 Proteins) angiogenic paracrine action via STAT5.
Our finding supports that STAT3 (show STAT3 Proteins) was the potential treated target for breast cancer therapy, whereas STAT5A/5B/6 were potential prognostic markers for better survival of BC, providing more accurate prognosis.
Similar to normal developmental programs, oncogenic functions of STAT5 rely on molecular crosstalk with PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling for the initiation, and in some instances the progression, of breast cancer. (Review)
As targets of oncogenes with intrinsic tyrosine kinase (show TXK Proteins) activity, STAT3 (show STAT3 Proteins) and STAT5 become constitutively active in hematologic neoplasms and solid tumors, promoting cell proliferation and survival and modulating redox homeostasis via regulation xCT (show SLC7A11 Proteins) expression. (Review)
we demonstrated that Imatinib mesylate (IM)impaired T cell survival through the inhibition of IL-7 (show IL7 Proteins) and STAT5-p but not TCR signaling which remained unaffected during IM therapy. Thus, off-target inhibitory effects of IM on IL-7 (show IL7 Proteins) and STAT5-p explain how T cell lymphopenia occurs in patients treated with IM.
Our results suggest the regulation of STAT5A via epigenetic mechanisms during normal pregnancy and the association of STAT5A epigenetic dysregulation in pregnancy related complications
dehydrocostus lactone significantly inhibits the phosphorylation expression of Bcr/Abl (show ABL1 Proteins), STAT5, JAK2 (show JAK2 Proteins), and STAT3 (show STAT3 Proteins) and downstream molecules including p-CrkL (show CRKL Proteins), Mcl-1 (show MCL1 Proteins), Bcl-XL (show BCL2L1 Proteins), and Bcl-2 (show BCL2 Proteins) proteins in K562 cells.
Two p53 (show TP53 Proteins) binding sites were mapped in the STAT5A gene and named PBS1 and PBS2; these sites were sufficient to confer p53 (show TP53 Proteins) responsiveness in a luciferase reporter gene.
NK cell numbers are decreased in Stat5a-Stat5b (show STAT5B Proteins) tetramer-deficient double knockin mice, but the mechanism was not investigated. Here we show that STAT5 dimers are sufficient for NK cell development, whereas STAT5 tetramers mediate NK cell maturation and the expression of maturation-associated genes.
endogenous growth hormone (show GH1 Proteins) induces UCP1 (show UCP1 Proteins) expression in adipose tissue via STAT5
Each mutation decreased STAT5 binding and altered IL-2 (show IL2 Proteins)-induced Il2ra (show IL2RA Proteins) gene expression, revealing that individual elements within the superenhancer were not functionally redundant and that all were required for normal gene expression.
findings indicate that STAT5 contributes to the remarkable IL-3 (show IL-3 Proteins)-mediated inhibition of RANKL (show TNFSF11 Proteins)-induced osteoclastogenesis by activating Id genes and their associated pathways.
Results suggest activation of H2AX (show H2AFX Proteins) via promoter demethylation in specific populations of basal mammary cells that is induced by a signal from neighboring luminal cells with hyper STAT5 activity.
On the basis of our ChIP data and these previous findings, we hypothesize that PDC (show PDC Proteins) may modulate STAT5's ability to regulate gene expression by controlling histone or STAT5 acetylation
STAT5 gene deletion had a minor effect on cholesterol metabolism, as evidenced by no changes in expression of cholesterol transport and cholesterol synthesis genes, and numeric changes in serum and liver cholesterol levels. These minor changes in cholesterol metabolism may not have been sufficient to influence on cholesterol crystal and gallstone formation in lithogenic diet-fed STAT5 LKO mice.
Stat5 deficiency has a strong impact upon transcriptional heterogeneity in single sorted c-Kit+Lin-Sca-1+ (KLS (show RPS6KB2 Proteins)) cells or CD150 (show SLAMF1 Proteins)+CD48 (show CD48 Proteins)- KLS (show RPS6KB2 Proteins) long-term repopulating hematopoietic stem cells.
mice carrying Stat5a/b inactivation specifically in kisspeptin cells were generated. These mutants exhibited an early onset of estrous cyclicity, indicating that STAT5 transcription factors exert an inhibitory effect on the timing of puberty.
these data suggest that ROCK2 (show ROCK2 Proteins) signaling plays a critical role in controlling the development of TFH cells induced by autoimmune conditions through reciprocal regulation of STAT3 (show STAT3 Proteins) and STAT5 activation.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (show JAK2 Proteins)-STAT5 and mTOR (show FRAP1 Proteins) signaling pathways.
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Milk production traits were analyzed for each animal in the first, second, third, and fourth lactation. No genetic variability was found at STAT5A/AvaI locus. At STAT5A/MslI locus, the frequencies of T and C alleles were 0.875 and 0.125, respectively. Significant differences between genotypes were found
Results indicate that SNPs in STAT5A and JAK2 (show JAK2 Proteins) genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
The embryonic STAT5A gene is primarily activated by maternal gene products and the most abundant STAT5A expression occurred at the 2-cell stage blastocysts.
INVESTIGATION OF STAT5A, FSHR (show FSHR Proteins) AND LHR (show LHCGR Proteins) GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS
The Stat5a gene is associated with an increase in lactation of mammary gland epithelial cells.
STAT5A/AvaI polymorphism seems to be a promising indirect marker to improve milk production traits in cattle.
Associations between reproduction and milk traits, and polymorphisms at the STAT5A and FGF2 (show FGF2 Proteins) gene loci, were found with STAT5A polymorphism for age at first calving (suggestive effect; P =0.077) and lactation milk yield (significant effect; P<0.05).
Base sequence variation in STAT5A-noncoding region was studied.
This study indicates that CISH (show CISH Proteins) functions as a conserved in vivo target and regulator of STAT5 (show STAT5B Proteins) in the control of embryonic hematopoiesis.
study demonstrates that STAT5 (show STAT5B Proteins) in basophils is activated through both the IL-3 (show IL-3 Proteins) and the FcepsilonRI (show FCER1G Proteins) signaling pathway
Studies demonstrate a conserved role for SOCS1 (show SOCS1 Proteins) in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2 (show JAK2 Proteins)-Stat5 (show STAT5B Proteins) pathway.
The stat5.1 (show STAT5B Proteins) gene lies next to the stat3 (show STAT3 Proteins) gene.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
mammary gland factor STAT5A
, mammary gland factor
, signal transducer and activator of transcription 5
, STAT5A, Mammary Gland Factor
, signal transducer and activator of transcription 5A
, signal transducer and activator of transcription 5A-like
, signal transducer and activator of transcription 5B