STAT5A Protein (Myc-DYKDDDDK Tag)
-
- Target See all STAT5A Proteins
- STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))
- Protein Type
- Recombinant
-
Origin
- Human
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This STAT5A protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
-
- Recombinant human STAT5 / STAT5A protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product STAT5A Protein
-
Signal Transducer and Activator of Transcription 5A (STAT5A) (AA 1-794) protein (GST tag)
STAT5A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Signal Transducer and Activator of Transcription 5A (STAT5A) (AA 1-104) protein (GST tag)STAT5A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Signal Transducer and Activator of Transcription 5A (STAT5A) (AA 1-793) protein (Strep Tag)Crystallography grade STAT5A Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Signal Transducer and Activator of Transcription 5A (STAT5A) (AA 1-794) protein (Strep Tag)Crystallography grade STAT5A Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
-
- Application Notes
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
-
The tag is located at the C-terminal.
- Restrictions
- For Research Use only
-
- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
- Target
- STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))
- Alternative Name
- Stat5,stat5a (STAT5A Products)
- Synonyms
- MGF Protein, STAT5 Protein, AA959963 Protein, Stat5 Protein, STAT5A/MGF Protein, STATA5 Protein, STAT5A Protein, stat5 Protein, stat5b Protein, signal transducer and activator of transcription 5A Protein, signal transducer and activator of transcription 5a Protein, STAT5A Protein, Stat5a Protein, stat5a Protein, LOC100348518 Protein, LOC100716811 Protein
- Background
- The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.
- Molecular Weight
- 90.5 kDa
- NCBI Accession
- NP_003143
- Pathways
- JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation
-
