SIGLEC5 ELISA Kit (Sialic Acid Binding Ig-Like Lectin 5)

Details for Product SIGLEC5 ELISA Kit No. ABIN5510738
Target
Binding Specificity
AA 17-441
Reactivity
Human
Alternatives
Kits with alternative reactivity to:
4
1
Detection Method
Colorimetric
Method Type
Sandwich ELISA
Application
ELISA
Options
Purpose Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Siglec5
Brand PicoKine™
Analytical Method Quantitative
Detection Method Colorimetric
Specificity Expression system for standard: NSO, Immunogen sequence: E17-L441
Cross-Reactivity (Details) There is no detectable cross-reactivity with other relevant proteins.
Characteristics

Tissue Specificity: Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

Target
Alternative Name SIGLEC5 (SIGLEC5 ELISA Kit Abstract)
Background

Protein Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Background: Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

Synonyms: Sialic acid-binding Ig-like lectin 5,Siglec-5,CD33 antigen-like 2,Obesity-binding protein 2,OB-BP2,OB-binding protein 2,CD170,SIGLEC5,CD33L2, OBBP2,

Full Gene Name: Sialic acid-binding Ig-like lectin 5

Cellular Localisation: Membrane, Single-pass type I membrane protein.
UniProt O15389
Plate Pre-coated
Restrictions For Research Use only
Storage 4 °C,-20 °C
Storage Comment Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
Expiry Date 12 months
Images
Image no. 1 for Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) ELISA Kit (ABIN5510738) Human Siglec5 PicoKine ELISA Kit standard curve