Browse our anti-ABHD5 (ABHD5) Antibodies

Human Abhydrolase Domain Containing 5 (ABHD5) interaction partners

1. our findings indicate that inhibition of both DGAT1 (show DGAT1 Antibodies) and ABHD5 using siRNA leads to reduction in prostate cancer cell growth.

2. Prebinding CGI-58 with PI(3 (show PI3 Antibodies))P or PI(5 (show SERPINB5 Antibodies))P did not alter its coactivation of ATGL (show PNPLA2 Antibodies) in vitro. In summary, purified recombinant CGI-58 that is functional as an ATGL (show PNPLA2 Antibodies) coactivator lacks LPAAT (show MBOAT2 Antibodies) activity.

3. It is clear that CGI-58 can regulate TAG hydrolysis by activating the major TAG hydrolase adipose triglyceride lipase (ATGL (show PNPLA2 Antibodies)), yet CGI-58 can also regulate lipid metabolism via mechanisms that do not involve ATGL (show PNPLA2 Antibodies).

4. ABHD5 possesses a PNPLA2 (show PNPLA2 Antibodies)-independent function in regulating autophagy and tumorigenesis.

5. These results indicate that HCV taps (show ASPRV1 Antibodies) into the lipid droplet triglyceride reservoir usurping ABHD5 lipase (show LIPG Antibodies) cofactor function

6. Case Report: novel ABHD5 mutation, c.838C > T (p.Arg280*), in trans with p.Arg234* in a Chinese patient with very mild Dorfman-Chanarin syndrome.

7. Authors show that rat ATGL (show PNPLA2 Antibodies), coactivated by rat CGI-58, efficiently hydrolyzes triglycerides and retinyl ester.

8. novel ABHD5 truncating variant in a twenty nine month old female child, who presented with icthyosiform erythroderma.

9. simultaneous tryptophan alanine permutations in both arms abolish localization and activity of CGI-58 as opposed to tryptophan substitutions that occur in only one arm.

10. this study presents clinical and molecular data of four affected relatives with Chanarin-Dorfman syndrome homozygous for a N209X mutation in ABHD5, and provides a short review by comparing patients with N209X homozygous mutations to patients with other ABHD5 mutations.

Mouse (Murine) Abhydrolase Domain Containing 5 (ABHD5) interaction partners

1. Mice lacking brown adipose tissue CGI-58 gene, a lipolytic activator essential for the stimulated lipid droplet lipolysis, have normal thermogenic capacity and are not cold sensitive.

2. Prebinding CGI-58 with PI(3 (show PI3 Antibodies))P or PI(5)P did not alter its coactivation of ATGL (show PNPLA2 Antibodies) in vitro. In summary, purified recombinant CGI-58 that is functional as an ATGL (show PNPLA2 Antibodies) coactivator lacks LPAAT (show AGPAT1 Antibodies) activity.

3. CGI-58 regulates hepatic neutral lipid storage and inflammation in the genetic absence of ATGL (show PNPLA2 Antibodies).

4. ABHD5 possesses a PNPLA2 (show PNPLA2 Antibodies)-independent function in regulating autophagy and tumorigenesis.

5. omega-O-AcylCer and CLE (show C14orf166 Antibodies) formation critically depend on CGI-58 expression in differentiated keratinocytes.

6. These results demonstrate that macrophage CGI-58 enhances PPAR-gamma (show PPARG Antibodies) signaling and thus suppresses inflammatory responsiveness and mitochondrial dysfunction in macrophages.

7. Here, we identify synthetic ligands that release ABHD5 from PLIN1 (show PLIN1 Antibodies) or PLIN5 (show PLIN5 Antibodies) without PKA activation and rapidly activate adipocyte and muscle lipolysis.

8. we identify adipocyte-type fatty acid-binding protein (A-Fabp (show FABP4 Antibodies)) and other members of the fatty acid-binding protein (Fabp (show FABP Antibodies)) family as interaction partners of Cgi-58.

9. Data (including data from studies in atherosclerotic knockout mice) suggest CGI58-deficient macrophages store-up triglyceride-rich droplets and have reduced phagocytic capacity, comparable to Atgl- (adipose triglyceride lipase (show PNPLA2 Antibodies)-)deficient macrophages.

10. -mediated phosphorylation of CGI-58 is required for dispersion of CGI-58 from perilipin (show PLIN1 Antibodies) 1A-coated lipid droplets

Pig (Porcine) Abhydrolase Domain Containing 5 (ABHD5) interaction partners

1. These findings suggest that CGI-58 may be a new target for enhancing the quality of pork products as well as offering the potential of CGI-58 for human obesity treatment.