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The combination of three proteins - apolipoprotein A-IV, complement factor H-related protein 4 and platelet basic protein - demonstrated the best classification performance for our data for diagnosis of growth hormone defic.
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ApoA-IV inversely correlates with platelet aggregation.ApoA-IV is an endogenous inhibitor of thrombosis. Aspartic acids 5 and 13 at the N-terminus of apoA-IV are required for binding to alphaIIbbeta3 integrin.
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The genotype-risk associations were examined between APOA4 (rs5095, rs675, rs5110) and obesity-related phenotypes and other comorbidities in Sucre, Venezuela. There was a higher average waist-hip ratio among rs5095 homozygotes and for conicity index among homozygotes for rs5110.
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Apolipoprotein L1 and apolipoprotein A-IV and their association with kidney function
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APOA-IV glycation is associated with coronary artery disease severity in patients with Type 2 Diabetes Mellitus.
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Renal AApoAIV amyloidosis typically presents with progressive chronic kidney disease and histologically exhibits extensive medullary involvement with sparing of the cortex. The diagnosis is best established by mass spectrometry.
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These findings indicate that LZIP is a novel modulator of APOA4 expression and hepatic lipid metabolism.
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Study discovered novel and independent associations of prediabetes and related traits with MASP1, and some evidence for associations with THBS1, GPLD1 and ApoA-IV, suggesting a role for these proteins in the pathophysiology of type 2 diabetes.
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Analyses of SNP-scores indicate potential causal effects of kidney function and by lesser extent triglycerides on apoA-IV concentrations.
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Low levels of APOA1, APOC3, and APOA4 are associated with risk of Alzheimer disease.
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Single nucleotide polymorphisms (Rs7396835) of APOA4 protein did not increase the risk of CHD in the Chinese population.
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ApoA-IV colocalizes with NR4A1, which suppresses G6Pase and PEPCK gene expression at the transcriptional level, reducing hepatic glucose output and lowering blood glucose.
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the present findings reveal that High-altitude polycythemia -induced gastric mucosal lesion inspires the protection responses by up-regulating APOA4 and APOC3, and down-regulating GIF.
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analysis of methylation patterns of the APOA1/C3/A4/A5 cluster that may be directly involved in the transcriptional regulation of this cluster, especially in liver
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the systematic conversion of conserved prolines to alanine increased the thermodynamic stability of apoA-IV and its propensity to oligomerize
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transcriptional regulation of apolipoprotein A-IV by the transcription factor CREBH
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human apolipoproteina4 and apolipoproteinc3 genes are suppressed by phorbol myristate acetate in hepatic and intestinal cells
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Human papillomavirus E5 oncoproteins bind the A4 in endoplasmic reticulum to regulate proliferative ability upon differentiation.
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The structure of human apolipoprotein A-IV as revealed by stable isotope-assisted cross-linking, molecular dynamics, and small angle x-ray scattering.
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apoA-IV inhibits hepatic gluconeogenesis by decreasing Glc-6-Pase and PEPCK gene expression through NR1D1.