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identification and characterization of CaM-binding domain of non-specific lipid transfer proteins
Study demonstrated that PLTP is overexpressed in synovial tissue of patients with chronic inflammatory rheumatisms, such as rheumatoid arthritis (RA), when compared to osteoarthritis patients (OA); and that RA but not OA patients displayed elevated levels of PLTP activity in synovial fluid, which were correlated with pro-inflammatory cytokine levels.
These results indicate that PLTP and MASP-1 can serve as plasma biomarkers for the early diagnosis and treatment of Age-related macular degeneration , which is critical for preventing Age-related macular degeneration -related blindness.
PLTP activity did not affect this metric. Thus, deviations in PLTP activity from the wild-type level reduce HDL mass and ex vivo cholesterol efflux capacity, but not the rate of macrophage cholesterol efflux to plasma or in vivo mRCT.
serum CETP and PLTP activity in patients diagnosed with hypothyroidism, was examined.
PLTP may regulate cigarette smoke extract-induced IL-8 expression via the ERK1/2 signaling pathway in human pulmonary epithelial cells
LPL and PLTP appear to be novel glioma-associated proteins and play a role in the progression of human glioma
association of PON-1 activity with PLTP activity was lost in analysis which included large HDL particles
a novel association between PLTPa and PON1 activity
The domain of apolipoprotein E4 required for PLTP activation resides within its amino-terminal 1-185 region.
Elevated baseline plasma levels of PLTP are associated with an increased risk of long-term all-cause mortality in patients with diabetes and known or suspected coronary disease.
This review summarizes the recent progresses made in the PLTP research field and focuses on the complexity of the implication of PLTP in obesity, insulin resistance and type 2 diabetes mellitus. [review]
Elevated plasma PLTP activity may predict an increased risk of T2DM in men
High systemic PLTP expression does not contribute significantly to a renal phenotype despite being implicated in systemic atherosclerosis in ApoE deficient mice.
proteolytic cleavage of PLTP by cathepsin G may enhance the injurious inflammatory responses that occur in COPD
PLTP is actively involved in lipid transfer, cholesterol efflux, HDL genesis, and remodeling at the blood-brain barrier.
Lower plasma CETP or higher PLTP activity was each associated with a significantly increased risk of cardiovascular disease.
Higher PLTP activity is associated with depressed LV systolic function in a dose-dependent manner.
In all the models with ApoE deficiency, elevated human PLTP expression causes higher levels of diet-induced atherosclerosis coinciding with decreased plasma levels of HDL cholesterol.
The physiological relevance of PLTP in intracellular lipid metabolism and signal transduction. [Review]
PLTP mediates PL transfer and participates in reverse cholesterol transport pathways at the fetoplacental barrier.
this work reports a physiological role for PLTP in the polarization of CD4(+) T cells toward the pro-inflammatory Th1 phenotype.
these findings elucidated that PLTP repressed LPS induced inflammation due to extracellular LPS binding capability, and the protective effects were not related to HDL pool size in mice.
Data presented a novel model to link phospholipid metabolism to APP processing and also suggested that PLTP played an important role in Abeta metabolism and would be useful to further elucidate functions of PLTP in Alzheimer's disease susceptibility.
In hepatocytes, initial recruitment of phospholipid (PL) by apoB:1000 leading to the formation of the PL-rich apoB-containing initiation complex is mediated to a large extent by PLTP.
PLTP plays an important role in modulating the stability of atherosclerotic plaques. The receptor-interacting protein 3- reactive oxygen species signal pathway could be involved in this PLTP-mediated process.
Adipocyte PLTP plays a small but significant role in plasma PLTP activity and promotes cholesterol efflux from adipose tissues.
PLTP exerts significant effects on apoA-I lipidation and nascent HDL biogenesis in hepatocytes by promoting ATP-binding cassette transporter A1-mediated lipid efflux and the remodeling of nascent HDL particles.
Plasma Sphingosine-1-phosphate contents were decreased by 60.1 % in PLTP knockout mice (PLTP-/-, N = 5) compared with their wild type littermates (WT, N = 5) (151.70 +/- 38.59 vs. 379.32 +/- 59.90 nmol/l, P<0.01).
Therefore we concluded that PLTP deficiency impaired cognition and aggravated AD by enhancing the generation of Abeta in the cortex of old mice.
Cerebrovascular oxidative stress increased in PLTP deficient mice, including increased levels of reactive oxygen species (ROS) and lipid peroxidation marker 4-hydroxy-2-nonenal (HNE) and reduced superoxide dismutase (SOD) activity.
PLTP can play a significant role in the pathophysiology of abdominal aortic aneurysm.
Liver-specific PLTP deficiency significantly reduces plasma HDL and apoB-containing lipoprotein levels.
The results of this study suggested that PLTP, through its ability to deliver vitamin E to the brain, constitutes an endogenous neuroprotective agent. Increasing PLTP activity may offer a new way to develop neuroprotective therapies.
Our results suggest, for the first time, that the major function of liver PLTP is to drive VLDL production and makes a small contribution to plasma PLTP activity.
presence of PLTP in tear fluid appears to be essential for maintaining a healthy and functional ocular surface
the SR-BI pathway contributes in unique ways to cholesterol metabolism and atherosclerosis susceptibility even in the presence of CETP
Diet-induced lipid accumulation in phospholipid transfer protein-deficient mice: its atherogenicity and potential mechanism
PLTP increases blood coagulation and worsens the extent of ischemic lesions in response to acute oxidative stress.
It is concluded that PLTP is essential in mediating the association of triacyl lipid A with lipoproteins, leading to extension of its residence time and to magnification of its proinflammatory and anticancer properties.
Results suggest that phospholipid transfer protein (PLTP) polymorphisms might be an important genetic influence on economic traits in Hanwoo (Korean cattle).
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.
phospholipid transfer protein
, BPI fold containing family E
, lipid transfer protein II
, plasma phospholipid transfer protein
, PLTP-like protein