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identification and characterization of CaM-binding domain of non-specific lipid transfer proteins
Study demonstrated that PLTP is overexpressed in synovial tissue of patients with chronic inflammatory rheumatisms, such as rheumatoid arthritis (RA), when compared to osteoarthritis patients (OA); and that RA but not OA patients displayed elevated levels of PLTP activity in synovial fluid, which were correlated with pro-inflammatory cytokine levels.
These results indicate that PLTP and MASP-1 (show MASP1 Proteins) can serve as plasma biomarkers for the early diagnosis and treatment of Age-related macular degeneration , which is critical for preventing Age-related macular degeneration -related blindness.
PLTP activity did not affect this metric. Thus, deviations in PLTP activity from the wild-type level reduce HDL (show HSD11B1 Proteins) mass and ex vivo cholesterol efflux capacity, but not the rate of macrophage cholesterol efflux to plasma or in vivo mRCT.
serum CETP (show CETP Proteins) and PLTP activity in patients diagnosed with hypothyroidism, was examined.
PLTP may regulate cigarette smoke extract-induced IL-8 expression via the ERK1/2 signaling pathway in human pulmonary epithelial cells
LPL (show LCP1 Proteins) and PLTP appear to be novel glioma-associated proteins and play a role in the progression of human glioma
association of PON-1 (show PON1 Proteins) activity with PLTP activity was lost in analysis which included large HDL (show HSD11B1 Proteins) particles
a novel association between PLTPa and PON1 (show PON1 Proteins) activity
The domain of apolipoprotein E4 required for PLTP activation resides within its amino-terminal 1-185 region.
Elevated baseline plasma levels of PLTP are associated with an increased risk of long-term all-cause mortality in patients with diabetes and known or suspected coronary disease.
this work reports a physiological role for PLTP in the polarization of CD4 (show CD4 Proteins)(+) T cells toward the pro-inflammatory Th1 (show HAND1 Proteins) phenotype.
these findings elucidated that PLTP repressed LPS (show TLR4 Proteins) induced inflammation due to extracellular LPS (show TLR4 Proteins) binding capability, and the protective effects were not related to HDL (show HSD11B1 Proteins) pool size in mice.
Data presented a novel model to link phospholipid metabolism to APP (show APP Proteins) processing and also suggested that PLTP played an important role in Abeta (show APP Proteins) metabolism and would be useful to further elucidate functions of PLTP in Alzheimer's disease susceptibility.
In hepatocytes, initial recruitment of phospholipid (PL) by apoB (show APOB Proteins):1000 leading to the formation of the PL-rich apoB (show APOB Proteins)-containing initiation complex is mediated to a large extent by PLTP.
PLTP plays an important role in modulating the stability of atherosclerotic plaques. The receptor-interacting protein 3 (show RIPK3 Proteins)- reactive oxygen species signal pathway could be involved in this PLTP-mediated process.
Adipocyte PLTP plays a small but significant role in plasma PLTP activity and promotes cholesterol efflux from adipose tissues.
PLTP exerts significant effects on apoA-I (show APOA1 Proteins) lipidation and nascent HDL (show HSD11B1 Proteins) biogenesis in hepatocytes by promoting ATP-binding cassette transporter A1 (show ABCA1 Proteins)-mediated lipid efflux and the remodeling of nascent HDL (show HSD11B1 Proteins) particles.
Plasma Sphingosine-1-phosphate contents were decreased by 60.1 % in PLTP knockout mice (PLTP-/-, N = 5) compared with their wild type littermates (WT, N = 5) (151.70 +/- 38.59 vs. 379.32 +/- 59.90 nmol/l, P<0.01).
Therefore we concluded that PLTP deficiency impaired cognition and aggravated AD by enhancing the generation of Abeta (show APP Proteins) in the cortex of old mice.
Cerebrovascular oxidative stress increased in PLTP deficient mice, including increased levels of reactive oxygen species (ROS) and lipid peroxidation marker 4-hydroxy-2-nonenal (HNE) and reduced superoxide dismutase (SOD) activity.
PLTP is actively involved in lipid transfer, cholesterol efflux, HDL (show HSD11B1 Proteins) genesis, and remodeling at the blood-brain barrier.
Results suggest that phospholipid transfer protein (PLTP) polymorphisms might be an important genetic influence on economic traits in Hanwoo (Korean cattle).
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.
phospholipid transfer protein
, BPI fold containing family E
, lipid transfer protein II
, plasma phospholipid transfer protein
, PLTP-like protein