Dynactin 1 Proteins

Protein Summary

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

Alternative names and synonyms associated with Dynactin 1 (DCTN1)

• dynactin subunit 1 (DCTN1) antibody
• dynactin subunit 1 (Dctn1) antibody
• dynactin 1 (Dctn1) antibody
• Dynactin 1, p150 subunit (DCTN1-p150) antibody
• dynactin subunit 1 L homeolog (dctn1.L) antibody

• AL022633 antibody
• CG9206 antibody
• Chip150 antibody
• DAP-150 antibody
• DCTN1 antibody
• Show all synonym aliases
• DKFZp469C1813 antibody
• Dmel\\CG9206 antibody
• DP-150 antibody
• Dynactin-1 antibody
• DYNA_DROME antibody
• FCP-D antibody
• Glu antibody
• glued antibody
• P135 antibody
• P150 antibody
• p150/glued antibody
• p150 antibody
• p150[glued] antibody
• t1 antibody

Protein level used designations for Dynactin 1 Proteins (DCTN1)

150 kDa dynein-associated polypeptide , dynactin 1 (p150, glued homolog, Drosophila) , dynactin subunit 1 , DAP-150 , DP-150 , p150-glued , dynactin 1 , dynactin subunit 1-like , dynactin 1, retrograde axonal transport , CG9206-PA , Gl-PA , dynactin , dynactin P150 , glued , p150[glued] , p150glued , dynactin 1 (p150, glued homolog)