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anti-Rat (Rattus) DYNC1H1 Antibodies:
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Human Polyclonal DYNC1H1 Primary Antibody for ELISA - ABIN4268688
Chen, Levedakou, Millen, Wollmann, Soliven, Popko: Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic Dynein heavy chain 1 gene. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Human Polyclonal DYNC1H1 Primary Antibody for ICC, IF - ABIN4306503
Barisic, Aguiar, Geley, Maiato: Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces. in Nature cell biology 2014
Data show that basal body docking was unaffected in dynein 1 (dync1h1) mutation, but rab GTP-binding protein Rab6 expression was reduced.
dync1h1 promotes axon ensheathment and myelin gene expression.
This study provided evidence that Dync1h1 is also required for efficient myelination of peripheral axons by Schwann cells, perhaps by facilitating signal transduction necessary for myelination.
demonstrate that the outward transport of dynein from soma to axon terminal is driven by direct interactions with the anterograde motor kinesin-1.
The Swl/Swl mutation of Dync1h1 gene led to embryonic mal (show TIRAP Antibodies)-development and lethality, whereas the Swl/+ DRG neurons demonstrated deficient retrograde transport in dynein-driven cargos and excessive apoptosis during mid- to late-developmental stages.
These data unveil a previously unrecognized role for the dynein-dynactin (show DCTN1 Antibodies) motor complex in osteoclast formation and function.
The Loa heterozygote phenotype is morphometrically depleted; in addition to dendritic axonal defects, the Loa mutation in a mouse model for mixed motor-sensory loss considers the entire neuraxis and is not a model for sensory loss.
Snapin (show SNAPIN Antibodies)-dynein coupling is one of the primary mechanisms driving BDNF (show BDNF Antibodies)-TrkB (show NTRK2 Antibodies) retrograde transport, thus providing mechanistic insights into the regulation of neuronal growth and survival.
Data show that amyloid precursor protein (APP (show APP Antibodies)) levels are well-correlated with the amount of the light chain of kinesin-1 (KLC1 (show KLC1 Antibodies)).
neuromuscular junction defects in mice with mutation of dynein heavy chain 1
Results provide genetic evidence that dynein plays a key role in lipid metabolism and thermogenesis.
These results suggest a potential role for the dynein tail in motor function, and provide direct evidence for a link between single-motor processivity and disease.
Impairment of retrograde transport by knockdown of DHC1 or BicD1 (show BICD1 Antibodies) inhibits stress-granule formation and P-body growth upon stress.
Taken together, these results demonstrate DYNC1H1 as a strong candidate and RTP1 (show RTP1 Antibodies) as a potential candidate on the onset of epileptic encephalopathies.
Here, the authors use quantitative imaging and laser ablation to show that NuMA targets dynactin to spindle microtubule minus-ends, localizing dynein activity there.
Structural and functional mutations and hotspots for DYNC1H1.
This observation offers an explanation for the dominant effects of DYNC1H1 mutations in vivo.
This cohort demonstrates that mutations in DYNC1H1 can mimic a congenital myopathy.
These results suggest that cytoplasmic dynein 1 binds to BRCA2 (show BRCA2 Antibodies) through the latter's centrosomal localization signal and BRCA2 (show BRCA2 Antibodies) mediates the cohesion between centrosomes during the S phase, potentially serving as a cell-cycle checkpoint.
A novel de novo mutation (c.2327C > T, p.P776L) in the DYNC1H1 gene identified and confirmed it as the causal variant of Spinal muscular atrophy with lower extremity predominance.
Our findings suggest that DYNC1H1 variants can cause not only lower, but also upper motor neuron disease.
The mutations in DYNC1H1 increase the interaction with its adaptor BICD2 (show BICD2 Antibodies).
Dynactin functions as both a dynamic tether and brake during dynein-driven motility.
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family.
cytoplasmic dynein 1 heavy chain 1
, cytoplasmic dynein
, MAP 1C
, cytoplasmic dynein heavy chain 1
, dynein heavy chain, cytosolic
, dynein, cytoplasmic, heavy chain 1
, dynein heavy chain, retrograde transport
, legs at odd angle
, dynein, cytoplasmic, heavy polypeptide 1