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Data show that basal body docking was unaffected in dynein 1 (dync1h1) mutation, but rab GTP-binding protein Rab6 expression was reduced.
dync1h1 promotes axon ensheathment and myelin gene expression.
This study provided evidence that Dync1h1 is also required for efficient myelination of peripheral axons by Schwann cells, perhaps by facilitating signal transduction necessary for myelination.
demonstrate that the outward transport of dynein from soma to axon terminal is driven by direct interactions with the anterograde motor kinesin-1.
The Swl/Swl mutation of Dync1h1 gene led to embryonic mal (show TIRAP Proteins)-development and lethality, whereas the Swl/+ DRG neurons demonstrated deficient retrograde transport in dynein-driven cargos and excessive apoptosis during mid- to late-developmental stages.
These data unveil a previously unrecognized role for the dynein-dynactin (show DCTN1 Proteins) motor complex in osteoclast formation and function.
The Loa heterozygote phenotype is morphometrically depleted; in addition to dendritic axonal defects, the Loa mutation in a mouse model for mixed motor-sensory loss considers the entire neuraxis and is not a model for sensory loss.
Snapin (show SNAPIN Proteins)-dynein coupling is one of the primary mechanisms driving BDNF (show BDNF Proteins)-TrkB (show NTRK2 Proteins) retrograde transport, thus providing mechanistic insights into the regulation of neuronal growth and survival.
Data show that amyloid precursor protein (APP (show APP Proteins)) levels are well-correlated with the amount of the light chain of kinesin-1 (KLC1 (show KLC1 Proteins)).
neuromuscular junction defects in mice with mutation of dynein heavy chain 1
Results provide genetic evidence that dynein plays a key role in lipid metabolism and thermogenesis.
These results suggest a potential role for the dynein tail in motor function, and provide direct evidence for a link between single-motor processivity and disease.
Impairment of retrograde transport by knockdown of DHC1 or BicD1 (show BICD1 Proteins) inhibits stress-granule formation and P-body growth upon stress.
These results suggest that cytoplasmic dynein 1 binds to BRCA2 (show BRCA2 Proteins) through the latter's centrosomal localization signal and BRCA2 (show BRCA2 Proteins) mediates the cohesion between centrosomes during the S phase, potentially serving as a cell-cycle checkpoint.
A novel de novo mutation (c.2327C > T, p.P776L) in the DYNC1H1 gene identified and confirmed it as the causal variant of Spinal muscular atrophy with lower extremity predominance.
Our findings suggest that DYNC1H1 variants can cause not only lower, but also upper motor neuron disease.
The mutations in DYNC1H1 increase the interaction with its adaptor BICD2.
Dynactin functions as both a dynamic tether and brake during dynein-driven motility.
These findings also reveal a possible new target for Amblyomin-X, i.e., dynein, and may serve as a tool for investigating tumor cell death associated with proteasome inhibition.
These results reveal that conformational changes involving hexon hypervariable region 1 are the basis for a novel viral mechanism controlling capsid transport to the nucleus by dynein.
Report expands the clinical spectrum of DYNC1H1-related spinal muscular atrophy to include generalized arthrogryposis
Authors propose that Snapin connects chlamydial inclusions with the microtubule network by interacting with both Chlamydia psittaci IncB and dynein.
Authors find that pharmacological or small interfering RNA (siRNA)-mediated inhibition of cytoplasmic dynein or the kinesin 1 heavy chain KIF5B (show KIF5B Proteins) delays HIV-1 uncoating.
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family.
cytoplasmic dynein 1 heavy chain 1
, cytoplasmic dynein
, MAP 1C
, cytoplasmic dynein heavy chain 1
, dynein heavy chain, cytosolic
, dynein, cytoplasmic, heavy chain 1
, dynein heavy chain, retrograde transport
, legs at odd angle
, dynein, cytoplasmic, heavy polypeptide 1