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anti-Human BUB3 Antibodies:
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Human Polyclonal BUB3 Primary Antibody for ICC, ELISA - ABIN1001948
Kalitsis, Earle, Fowler, Choo: Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. in Genes & development 2000
Show all 4 Pubmed References
Human Polyclonal BUB3 Primary Antibody for ICC, ELISA - ABIN1887091
Jiang, Li, Yang, Hawke, Zheng, Xia, Aldape, Wei, Guo, Chen, Lu: PKM2 regulates chromosome segregation and mitosis progression of tumor cells. in Molecular cell 2014
Human Polyclonal BUB3 Primary Antibody for WB - ABIN1981301
Morais da Silva, Moutinho-Santos, Sunkel: A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition. in The Journal of cell biology 2013
Human Polyclonal BUB3 Primary Antibody for ICC, IF - ABIN4285582
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
Small sequence differences in Bub1 (show BUB1 Antibodies) and BubR1 (show BUB1B Antibodies) direct Bub3 to different phosphorylated targets in the spindle assembly checkpoint signaling cascade.
The integrity of the mitotic checkpoint complex depends on the specific recognition between BubR1 (show BUB1B Antibodies) and Bub3, for which the BubR1 (show BUB1B Antibodies) Gle2 (show RAE1 Antibodies) binding sequence motif is essential.
We show that kinetochore recruitment of BUBR1 (show BUB1B Antibodies) and BUB3 by BUB1 (show BUB1 Antibodies) is dispensable for SAC (show ADCY10 Antibodies) activation
a mutual antagonism exists between Bub3 and dynein to ensure optimal KT-MT attachments
the mechanisms of BUB3 in mitotic checkpoint signaling
Data show sequential multisite regulation of the microtubule-associated protein KNL1 (show CASC5 Antibodies)-kinase-adaptor complex BUB1 (show BUB1 Antibodies)/BUB3 interaction.
Data indicate that cell cycle protein Bub3-mediated kinetochore recruitment of BubR1 (show BUB1B Antibodies) kinase enhances mitotic checkpoint signaling.
Results suggest that these USP7 (show USP7 Antibodies)-dependent effects are mediated by decreased levels of spindle assembly checkpoint (SAC (show ADCY10 Antibodies)) component Bub3.
Mutations targeting the Bub3 interface prevent kinetochore recruitment of the SAC (show ADCY10 Antibodies) kinase Bub1 (show BUB1 Antibodies). Crucially, they also cause a checkpoint defect, showing that recognition of phosphorylated targets by Bub3 is required for checkpoint signaling
Results showed that neither variants in BUB3 nor variants in MAD2L1 (show MAD2L1 Antibodies) caused any significant effect on the risk of breast cancer
Data show that Zfp207 binds to Bub3 to form a complex and maintains its protein level in oocytes, and that overexpression of Bub3 is able to partially rescue the occurrence of aneuploid eggs in Zfp207-depleted oocytes.
as a member of the spindle assembly checkpoint, Bub3 is required for regulation of both meiosis I and II, and is potentially involved in kinetochore-microtubule attachment in mammalian oocytes
Cenpa (show CENPA Antibodies), Cenpb (show CENPB Antibodies), and Bub3, but not Cenpc (show CENPC1 Antibodies), interacted with PARP-1 (show PARP1 Antibodies)
Haploinsufficiency of Bub3 causes a slight increase in chromosome instability but is not clearly associated with a noticeable rise in the probability of tumor formation.
subpopulation of dynein, containing the DYNLT3 (show DYNLT3 Antibodies) light chain, may be important for chromosome congression, in addition to having a role in the transport of checkpoint proteins from the kinetochore to the spindle pole
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
BUB3 budding uninhibited by benzimidazoles 3 homolog
, budding uninhibited by benomyl
, budding uninhibited by benzimidazoles 3 homolog
, mitotic checkpoint component
, mitotic checkpoint protein BUB3
, WD repeat protein Bub3
, WD repeat type I transmembrane protein A72.5