Browse our anti-Caveolin-1 (CAV1) Antibodies

Zebrafish Caveolin 1, Caveolae Protein, 22kDa (CAV1) interaction partners

1. These results point to intestinal epithelial cell CAV1 as a potential therapeutic target to lower circulating free fatty acids and LDL cholesterol.

2. Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration.

3. The development of transgenic zebrafish lines expressing CLTA (show CLTA Antibodies) fused to dsRed and CAV1 fused to GFP is reported.

4. maternally expressed zebrafish Cav-1 regulates dorsoventral patterning by limiting nuclear translocation of active beta-catenin (show CTNNB1 Antibodies)

5. These results support important and previously unanticipated roles for the Caveolin-1 isoforms in vertebrate organogenesis.

Xenopus laevis Caveolin 1, Caveolae Protein, 22kDa (CAV1) interaction partners

1. interactions of cav1 at lipid-exposed domains regulate the partition of the receptor into membrane raft microdomains

Mouse (Murine) Caveolin 1, Caveolae Protein, 22kDa (CAV1) interaction partners

1. This study defines ZNRF1 (show ZNRF1 Antibodies) as a regulator of TLR4 (show TLR4 Antibodies)-induced inflammatory responses and reveals another mechanism for the regulation of TLR4 (show TLR4 Antibodies) signalling through CAV1.

2. Renal Cav1 promotes water and salt reabsorption via modulation of NCC (show SLC12A3 Antibodies) function and regulation of vascular eNOS (show NOS3 Antibodies).

3. Sirt1 (show SIRT1 Antibodies) preserves Cav1-dependent endothelial function by mitigating miR (show MLXIP Antibodies)-204-mediated vascular endoplasmic reticulum stress.

4. Cav1 is an important inhibitor of TGF-&beta (show TGFB1 Antibodies);1/Smad (show SMAD1 Antibodies) signaling in hepatic stellate cell activation and collagen production.

5. the present study indicated that Cav-1-/- accelerated liver injury in a mouse model of liver fibrosis through enhancing oxidative stress, inflammatory response and fibrosis progression

6. MURC (show MURC Antibodies) binds to Cav1 and inhibits the association of Cav1 with the active form of Galpha13 (show GNA13 Antibodies), resulting in the facilitated association of the active form of Galpha13 (show GNA13 Antibodies) with p115RhoGEF (show ARHGEF1 Antibodies). These results reveal that MURC (show MURC Antibodies) has a function in the development of pulmonary hypertension through modulating Rho/ROCK signaling.

7. The part of PKC regulation of CaV1.2 in the heart involves changes in channel's cellular fate. The mechanism of this PKC regulation appears to involve the C-terminus of alpha1C, possibly corroborating the previously proposed role of NT-CT interactions within alpha1C.

8. Findings suggest that CAV1 might be involved in apoptosis and proliferation regulation in pancreatic beta cells.

9. Caveolin1 is required for Th1 (show HAND1 Antibodies) cell infiltration, but not tight junction remodeling at the Blood-Brain Barrier in autoimmune neuroinflammation

10. Results suggest distinct functional roles for type 1 ryanodine receptor (RYR1 (show RYR1 Antibodies)) and Ca2 (show CA2 Antibodies)+ channels-the 1,4-dihydropyridine receptor (Cav1.1 (show CACNA1S Antibodies)) in skeletal primary and secondary myogenesis.

Human Caveolin 1, Caveolae Protein, 22kDa (CAV1) interaction partners

1. Study provides evidence that KIF13B (show KIF13B Antibodies) and NPHP4 (show NPHP4 Antibodies) are both required for establishment of a specialized caveolin-1 membrane microdomain at the ciliary transition zone, which is essential for Shh (show SHH Antibodies)-induced accumulation of SMO in the primary cilium as well as for activation of GLI (show GLI1 Antibodies)-mediated target gene expression.

2. High CAV1 expression is associated with gastric cancer cell migration.

3. Study shows that progression-related loss of stromal caveolin 1 levels fosters the growth of human PC3 (show PCSK1 Antibodies) xenografts and mediates radiation resistance.

4. Results found decreasing trend of cav-1 (transcripts I and II) in tumoral tissues especially in stages I and II and seem to be associated with the incidence and promotion of breast cancer, especially in the initial stages of breast cancer.

5. stromal expression of CAV1 in primary tumors was not associated with clinical outcome whereas the stromal expression of especially CAV2 (show CAV2 Antibodies) in the metastatic lymph nodes could be associated with lung cancer pathogenesis.

6. CAV-1 is important for NAFLD (show TSC2 Antibodies)-HCC (show FAM126A Antibodies) survival in fatty acid-rich environments and is a potential therapeutic target.

7. At the onset of mitotic cell rounding, caveolin-1 is targeted to the retracting cortical region at the proximal end of retraction fibres, where ganglioside GM1-enriched membrane domains with clusters of caveola-like structures are formed in an integrin and RhoA (show RHOA Antibodies)-dependent manner.

8. down-regulation of Cav-1 may aggravate DNA damage of Chang liver cells through reducing the interaction of Cav-1 and Mdm2 (show MDM2 Antibodies), which results in the promotion of p53 (show TP53 Antibodies) degradation.

9. High CAV1 expression is associated with Small Cell Lung Cancer.

10. NEDD8 (show NEDD8 Antibodies) seems to inhibit the Src (show SRC Antibodies)-mediated phosphorylation of caveolin-1 by modifying the structure of caveolin-1 protein, which blocks the migration of cancer cells. Although the neddylation process is currently regarded as an emerging target for cancer therapy, our results suggest the possibility that the inhibition of neddylation could facilitate cancer invasion or metastasis at least in some types of cancers.

Pig (Porcine) Caveolin 1, Caveolae Protein, 22kDa (CAV1) interaction partners

1. Caveolin-1 is a modulator of fibroblast activation and a potential biomarker for gastric cancer

2. transcription factor Sp1 (show SP1 Antibodies) interacts with nucleotides -123/-114, indicating that Sp1 (show SP1 Antibodies) could play a key role in the transcriptional regulation of pig CAV-1

3. Two alternative transcript variants encode two isoforms, caveolin-1-alpha and -beta; Cav1 may be implicated in pathogenesis of Glasser's disease of swine.

4. The plasma membrane Na/K-ATPase (show ATP1A1 Antibodies)-caveolin-1 interaction may represent an important sensing mechanism by which the cells regulate the sterol regulatory element-binding protein (show CNBP Antibodies) pathway.

5. The present study indicates that caveolin-containing rafts/caveolins such as caveolin-1 could play a modulating role during oligodendroglial differentiation and regeneration via NGF (show NGFB Antibodies)/TrkA (show NTRK1 Antibodies) signaling.

6. Cav-1 might be a candidate gene for carcass traits, and might provide valuable information for understanding the mechanism of caveolae signaling in fat deposition by using the animal model of pig

Rabbit Caveolin 1, Caveolae Protein, 22kDa (CAV1) interaction partners

1. ATRA is able to ameliorate highfatinduced AS in rabbits, which is mediated through the activation of eNOS (show NOS3 Antibodies) and downregulating CAV1 expression.

2. Caveolin-1 expression ameliorates nephrotic damage in a rabbit model of cholesterol-induced hypercholesterolemia.

3. 8-Bromo-cAMP stimulated alpha-methyl-D-glucopyranoside uptake via Epac and PKA-dependent SGLTs expression and trafficking through cav-1 and F-actin in proximal tubule cells.

Cow (Bovine) Caveolin 1, Caveolae Protein, 22kDa (CAV1) interaction partners

1. Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt (show AKT1 Antibodies) signaling

2. Data show that resveratrol (Res) reversed caveolin-1 (Cav-1)/endothelial nitric oxide synthase (eNOS (show NOS3 Antibodies)) expressions in high glucose cultured bovine aortic endothelial cells (BAECs).

3. these data provide the first detailed analysis of Cav-1 binding to one of its most significant client proteins, eNOS (show NOS3 Antibodies).

4. Study identifies a critical role of caveolin-1 in the regulation of eNOS (show NOS3 Antibodies) uncoupling via a biopterin-dependent mechanism.

5. Data indicate that caveolin-1 expression is required for insulin (show INS Antibodies) uptake by aortic endothelial cells.

6. caveolin-1 is not required for the targeting of signaling molecules to caveolae/lipid rafts

7. integrin activation with shear stress results in SFK-regulated caveolin-1 phosphorylation that, in turn, mediates Csk (show CSK Antibodies) association at integrin sites, where it plays a role in downstream, shear-stimulated myelin light chain diphosphorylation.

8. importance of CAV1 amino acids 89-95 and particularly F92 in mediating eNOS (show NOS3 Antibodies) inhibition by AP-Cav and Cav-1

9. When endothelial cells were exposed to shear stress, caveolin-1 was transiently dephosphorylated.

10. caveolin-1 tyrosine 14 phosphorylation has a role in cell adhesion and migration

Guinea Pig Caveolin 1, Caveolae Protein, 22kDa (CAV1) interaction partners

1. results suggest that cell division control protein 42(CDC42 (show CDC42 Antibodies)) activation is favored by the disruption of the caveolin-1-CDC42 (show CDC42 Antibodies) interaction, allowing for its participation in the regulation of capacitation and the acrosome reaction

Caenorhabditis elegans (C. elegans) Caveolin 1, Caveolae Protein, 22kDa (CAV1) interaction partners

1. The distribution of CAV-1 is highly dynamic during development and provides new insights into the sorting mechanisms that regulate CAV-1 localization.