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The differentially expressed C21orf5 gene in the medial temporal-lobe system could play a role in Down syndrome.
C21orf5 selective expression in the key brain structures for learning and memory suggests that C21orf5 overexpression could participate in mental retardation pathogenesis in Down syndrome patients.
C21orf5, could play a role in brain morphogenesis and, when overexpressed, it could participate in neurological features and mental retardation observed in DS patients.
Results quantify and statistically analyze, for the first time, DOPEY2 expression variations in different regions of the Down syndrome human fetal brains and to compare them to corresponding normal brains.
We proposed DOPEY2 as potential candidate gene for these cerebellar alterations considering its high expression in the brain.
May be involved in protein traffic between late Golgi and early endosomes (By similarity).
dopey family member 2
, protein dopey-2
, protein dopey-2-like
, homolog of yeast DOP1