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anti-Human Fibrillin 2 Antibodies:
anti-Mouse (Murine) Fibrillin 2 Antibodies:
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Human Polyclonal Fibrillin 2 Primary Antibody for IHC, IHC (fro) - ABIN4311657
Yabe, Hagiwara, Tsuchiya, Honda, Hatori, Sonofuchi, Kanazawa, Koide, Sekiguchi, Itaya, Itoi: Decreased elastic fibers and increased proteoglycans in the ligamentum flavum of patients with lumbar spinal canal stenosis. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2016
Show all 2 Pubmed References
BAV patients have an increased FBN (show FBN1 Antibodies) (especially FBN2) gene expression level in the ascending aorta, irrespective of dilatation, whereas MMP expression does not change significantly.
A novel missense mutation, c.3769T>C (p.C1257R) in FBN2 was identified responsible for the genetic cause in a family with congenital contractural arachnodactyly.
Study described a novel mutation seen in a family with three generations of congenital contractural arachnodactyly (CCA). Whole exome sequencing in two affected individuals identified a novel missense mutation in the FBN2 gene in all affected family members.
The presence of the splice site mutation in FBN2 gene has been confirmed in a Japanese family with congenital contractural arachnodactyly complicated with aortic dilatation and dissection.
DNA sequence variation within the FBN2 gene is associated with both Achilles tendon (AT) and anterior cruciate ligament (ACL (show ACLY Antibodies)) rupture.
Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration.
we demonstrate an important role for FBN1 (show FBN1 Antibodies) and FBN2 in AIS (show AR Antibodies) pathogenesis. We show that rare variants are enriched in severely affected AIS (show AR Antibodies) patients and are significantly associated with curve severity.
There was no association of overall methylation of FBN2 in the serum DNA with age, maximal tumor size, extent of tumor, tumor site, histology, presence of lymph node metastasis, distant metastasis, or Dukes' stage.
These results suggest that both fibrillin-1 (show FBN1 Antibodies) and fibrillin-2 are essential for the formation of thick oxytalan fibers in the ciliary zonule.
Data demonstrated that N-terminal fibrillin-2 epitopes are masked in postnatal microfibrils.
Studies provide evidence for the unique role of fibrillin-2 in regulating BMP-dependent limb patterning and its distinct impact from fbn1 (show FBN1 Antibodies) proteins on the commitment and differentiation of marrow mesenchymal stem cells. [review]
Fibrillin-2 and periostin (show POSTN Antibodies) are target genes in Osterix (show SP7 Antibodies)-mediated osteoblast differentiation.
These results suggest that both fibrillin-1 (show FBN1 Antibodies) and fibrillin-2 expression is required to form thick oxytalan fibers in periodontal ligament.
Fibrillin-2 plays a role in forelimb muscle differentiation and infiltration of fat into the limb connective tissue space.
the bronchial epithelial dysplasia accompanying microfibril dysregulation in Adamtsl2 (show ADAMTSL2 Antibodies)(-/-) mice cannot be reversed by TGFbeta (show TGFB1 Antibodies) neutralization, and thus might be mediated by other mechanisms.
We propose that the Mp "worse-than-null" eye phenotype plausibly results from a failure in normal trafficking of proteins that are co-expressed with Fbn2 within the ciliary margin
Fbn2 has an indispensable role in ocular morphogenesis in mice. The high incidence of iris coloboma in Fbn2-null animals implies a previously unsuspected role in optic fissure closure.
fibrillin-2 exerts a greater positive influence on the mechanical properties of bone than fibrillin-1 (show FBN1 Antibodies) assemblies
Fibrillin-1 and -2, the structural components of extracellular microfibrils, differentially regulate TGF-beta and bone morphogenetic protein (BMP) bioavailability in bone.
Findings indicate that Fbn2 is involved in integrity of structures required for strength in limb movement.
The coordinate upregulation of fibrillin-1 (show FBN1 Antibodies) and fibrillin-2 expression with the onset of tropoelastin (show ELN Antibodies) production is consistent with a role in elastic fiber assembly.
This is the first study to investigate the expression and localization of fibrillin proteins and latent TGF-beta (show TGFB1 Antibodies) binding proteins affecting TGFbeta (show TGFB1 Antibodies) bioavailability in the ovary.
The protein encoded by this gene is a component of connective tissue microfibrils and may be involved in elastic fiber assembly. Mutations in this gene cause congenital contractural arachnodactyly.
, syndatyly ems
, fibrillin 2
, fibrillin 2 (congenital contractural arachnodactyly)
, LOW QUALITY PROTEIN: fibrillin-2