-
PIST, a Golgi-associated PDZ domain-containing protein, interacts with PCDH15 in the plasma membrane.
-
CAL can regulate the anterograde trafficking, the internalization as well as the signaling of CRFR1 via modulating the post-translational modifications that the receptor undergoes at the Golgi apparatus.
-
CAL overexpression retards B2AR expression in Golgi apparatus and reduces the receptor expression in the plasma membrane.
-
Six out of 65 (9%) BTC patients were positive for the FIG-ROS1 fusion, comprising two out of 14 (14%) gallbladder carcinoma (GBC) patients and four out of 25 (16%) extrahepatic cholangiocarcinoma (ECC) patients.
-
Our data suggest that PIST contributes to the fine-tuning of b1AR sorting both during biosynthetic and postendocytic trafficking
-
None of 268 gliomas analysed showed the FIG-ROS1(L) rearrangement.
-
Stereochemical preferences modulate affinity and selectivity among CAL PDZ domain protein variants that bind CFTR.
-
FIG-ROS fusion protein, which is found in a subset of intrahepatic cholangiocarcinoma patients, accelerates cholangiocarcinogenesis.
-
Data indicate that E3 ubiquitin ligase MARCH2 co-immunoprecipitated and co-localized with CAL and syntaxin 6 (STX6), and show the ubiquitination of CFTR by MARCH2.
-
The coiled-coil domain of PIST was then purified to homogeneity and crystallized at 293 K. Finally, X-ray diffraction data were collected to a resolution of 4.0 A from a crystal belonging to the hexagonal space group P6(2)22 or P6(4)22.
-
crystals of CAL PDZ domain diffracted to 1.4 A resolution
-
establish CAL inhibitors as founding members of a class of CFTR "stabilizers" specifically designed to reduce DeltaF508-CFTR post-endocytic breakdown
-
Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator
-
The FIG-ROS locus encodes for an in-frame fusion protein with a constitutively active kinase activity, suggesting that FIG-ROS may act as an oncogene.
-
CAL retains CFTR in the cell and targets CFTR for degradation.
-
modulates beta1AR intracellular trafficking
-
golgin-160 assosiates in an isoform-specific manner with the Golgi-associated protein PIST
-
intracellular sorting of the somatostatin receptor subtype 5 is regulated by interactions with PDZ domain proteins PIST/GOPC and PDZK1
-
Our discoveries provide insight into the specific interaction of the GOPC PDZ domain with the C-terminal peptide of Nlg and also provide a general insight about the possible binding mode of the interaction of Nlg with other PDZ domain-containing proteins.
-
CAL is a negative regulator of DeltaF508-CFTR cell-surface expression
