Browse our anti-GOPC (GOPC) Antibodies

Mouse (Murine) Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC) interaction partners

1. Six putative caspase substrates, including five novel proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis, were identified.[caspase 10]

2. PIST protein, mouse plays an important role in regulating the intracellular sorting/ localization of cadherin 23.

3. predominantly localized at the trans-Golgi region in round spermatids; male mice in which GOPC has been disrupted are infertile with globozoospermia

4. Gopc-deficient spermatids fail to assemble the peri-nuclear structures in round-headed spermatozoa during spermatogenesis.

5. The coiled tail of the round-headed spermatozoa appears during epididymal passage in Gopc-deficient mice.

6. Transmission electron microscope (TEM) images of the spermatozoa were studied quantitatively to analyze disorganization processes during epididymal passage in Gopc knockout mice.

Human Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC) interaction partners

1. PIST, a Golgi-associated PDZ domain-containing protein, interacts with PCDH15 in the plasma membrane.

2. CAL can regulate the anterograde trafficking, the internalization as well as the signaling of CRFR1 via modulating the post-translational modifications that the receptor undergoes at the Golgi apparatus.

3. CAL overexpression retards B2AR expression in Golgi apparatus and reduces the receptor expression in the plasma membrane.

4. Six out of 65 (9%) BTC patients were positive for the FIG-ROS1 fusion, comprising two out of 14 (14%) gallbladder carcinoma (GBC) patients and four out of 25 (16%) extrahepatic cholangiocarcinoma (ECC) patients.

5. Our data suggest that PIST contributes to the fine-tuning of b1AR sorting both during biosynthetic and postendocytic trafficking

6. None of 268 gliomas analysed showed the FIG-ROS1(L) rearrangement.

7. Stereochemical preferences modulate affinity and selectivity among CAL PDZ domain protein variants that bind CFTR.

8. FIG-ROS fusion protein, which is found in a subset of intrahepatic cholangiocarcinoma patients, accelerates cholangiocarcinogenesis.

9. Data indicate that E3 ubiquitin ligase MARCH2 co-immunoprecipitated and co-localized with CAL and syntaxin 6 (STX6), and show the ubiquitination of CFTR by MARCH2.

10. The coiled-coil domain of PIST was then purified to homogeneity and crystallized at 293 K. Finally, X-ray diffraction data were collected to a resolution of 4.0 A from a crystal belonging to the hexagonal space group P6(2)22 or P6(4)22.

11. crystals of CAL PDZ domain diffracted to 1.4 A resolution

12. establish CAL inhibitors as founding members of a class of CFTR "stabilizers" specifically designed to reduce DeltaF508-CFTR post-endocytic breakdown

13. Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator

14. The FIG-ROS locus encodes for an in-frame fusion protein with a constitutively active kinase activity, suggesting that FIG-ROS may act as an oncogene.

15. CAL retains CFTR in the cell and targets CFTR for degradation.

16. modulates beta1AR intracellular trafficking

17. golgin-160 assosiates in an isoform-specific manner with the Golgi-associated protein PIST

18. intracellular sorting of the somatostatin receptor subtype 5 is regulated by interactions with PDZ domain proteins PIST/GOPC and PDZK1

19. Our discoveries provide insight into the specific interaction of the GOPC PDZ domain with the C-terminal peptide of Nlg and also provide a general insight about the possible binding mode of the interaction of Nlg with other PDZ domain-containing proteins.

20. CAL is a negative regulator of DeltaF508-CFTR cell-surface expression