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Human Polyclonal KEAP1 Primary Antibody for IF (p), IHC (p) - ABIN702085
Su, Zhang, Song, Shi, Fu, Xia, Bai, Hu, Xu, Song, Song: Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation. in Chemical research in toxicology 2015
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Human Monoclonal KEAP1 Primary Antibody for ICC, FACS - ABIN1098137
Kim, You, Lee, Ahn, Seong, Hwang: Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. in Cellular signalling 2010
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Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN1098141
Muscarella, Barbano, DAngelo, Copetti, Coco, Balsamo, la Torre, Notarangelo, Troiano, Parisi, Icolaro, Catapano, Valori, Pellegrini, Merla, Carella, Fazio, Parrella: Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. in Epigenetics 2011
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Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN2453954
Mercado, Kizawa, Ueda, Xiong, Kimura, Moses, Curtis, Ito, Barnes: Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers. in PLoS ONE 2014
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Human Polyclonal KEAP1 Primary Antibody for ELISA, IHC - ABIN4328595
Dinkova-Kostova, Talalay, Sharkey, Zhang, Holtzclaw, Wang, David, Schiavoni, Finlayson, Mierke, Honda: An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1. in The Journal of biological chemistry 2010
Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN4328597
Licht-Mayer, Wimmer, Traffehn, Metz, Brück, Bauer, Bradl, Lassmann: Cell type-specific Nrf2 expression in multiple sclerosis lesions. in Acta neuropathologica 2015
Cow (Bovine) Polyclonal KEAP1 Primary Antibody for IHC, WB - ABIN2775979
Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006
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High cytoplasmic Keap1 expression, which might prevent nuclear translocation of Nrf2 (show GABPA Antibodies) in ovarian cancer cells, was associated with lower disease recurrence and death rate.
The ratio of thioredoxin (show TXN Antibodies)/Keap1 protein level may be useful for suggesting distant metastasis in colorectal cancer.
our study pinpoints that PAQR3 (show PAQR3 Antibodies) functions as an adaptor protein to promote Nrf2 (show GABPA Antibodies)-Keap1 complex formation, thereby modulating the Nrf2 (show GABPA Antibodies)-Keap2 pathway and playing an important role in controlling antioxidant response of the cell
provide a rationale for stratification of human patients with lung cancer harboring KRAS/KEAP1- or KRAS/NRF2 (show GABPA Antibodies)-mutant lung tumors as likely to respond to glutaminase (show GLS Antibodies) inhibition
Our results identified ECG as a novel Keap1-Nrf2 (show GABPA Antibodies) interaction disruptor and LPS (show IRF6 Antibodies)-induced TLR4 (show TLR4 Antibodies) activation inhibitor, thereby providing an innovative strategy to prevent or treat immune, oxidative stress and inflammatory-related diseases
The Keap-1/Nrf2 (show GABPA Antibodies) redox system is a biological target of SSNO.
Molecular docking studies revealed that Wogonin can disrupt KEAP-1/Nrf-2 (show GABPA Antibodies) interaction by directly blocking the binding site of Nrf-2 (show GABPA Antibodies) in the KEAP-1 protein. The study provides novel insights into the development of Nrf2 (show GABPA Antibodies) as a promising candidate and Wogonin as a therapeutic agent for the management of Osteoarthritis .
Data show that genistein induced re-expression of the methylated Keap1 genes through demethylation in A549 cells, however, no Keap1 mRNA expression changes were detected in MRC-5 fibroblast cells.
Punicalagin protects HepG2 cells from lipotoxicity induced by free fatty acids through activating Nrf2 (show GABPA Antibodies)/Keap1 pathway.
Data suggest that Keap1, rather than Nrf2 (show GABPA Antibodies), is critical for the recruitment of iASPP (show PPP1R13L Antibodies) into the Keap1-Nrf2 (show GABPA Antibodies) complex
the potency of 15d-PGJ2 as a signalling molecule (show GDF5 Antibodies) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin
The p62 (show GTF2H1 Antibodies)-keap1-Nrf2 (show NFE2L2 Antibodies) antioxidant pathway was primarily activated in the early stage of APAP hepatotoxicity.
Keap1 deletion in renal tubular cells results in an abnormal kidney development consistent with hydronephrosis.
serine 351 phosphorylation of p62 (show GTF2H1 Antibodies) did not enhance its binding to Keap1 or stabilise the nuclear factor erythroid 2-related factor 2 (Nrf2 (show NFE2L2 Antibodies)) transcription factor in this neuronal context. Nrf2 (show NFE2L2 Antibodies) protein levels were markedly decreased despite transcriptional activation of the Nrf2 (show NFE2L2 Antibodies) gene
These results suggest that the Keap1/Nrf2 (show NFE2L2 Antibodies) axis plays a critical role in NFATc1 (show NFATC1 Antibodies) expression and osteoclastogenic progression.
Results show that Keap1 deficiency in long-term hematopoietic stem cells increases the number of multipotent progenitor cells in steady-state hematopoiesis, and impairs their hematopoietic regeneration capacity .
During cellular stress or electrolytic imbalance, cysteine residue modification in Keap1 induces Nrf2 (show NFE2L2 Antibodies) release from the Nrf2 (show NFE2L2 Antibodies)-Keap1 complex, which stabilizes Nrf2 (show NFE2L2 Antibodies) and causes its nuclear translocation.
Results showed that in the basal state, the amount of Keap1 and Cul3 (show CUL3 Antibodies) proteins were maintained at higher levels than that of Nrf2 (show NFE2L2 Antibodies), and remained the same even under oxidative and electrophilic stimuli.
This study found that under oxidative stress induced (show SQSTM1 Antibodies) by experimental periodontitis, the Nrf2 (show NFE2L2 Antibodies)/antioxidant defense pathway was activated and could be visualized from the luciferase activity in the in Keap1-dependent oxidative stress detector-luciferase mice model.
Caffeic acid induces Nrf2 (show NFE2L2 Antibodies) activation by decreasing the expression of its inhibitor protein Keap1 and blocking the binding of Nrf2 (show NFE2L2 Antibodies) with Keap1.
Hepatocyte-specific deletion of Keap1 triggering constitutive Nrf2 (show NFE2L2 Antibodies) activation shifts hepatic metabolism towards increased lipid catabolism, reduced liponeogenesis and activation of the pentose phosphate pathway.
These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1, disrupting the Keap1-Nrf2 (show NFE2L2 Antibodies) complex, thereby liberating and activating Nrf2 (show NFE2L2 Antibodies). Our findings of natural product-derived Nrf2 (show NFE2L2 Antibodies) activators lead to design options of potent Nrf2 (show NFE2L2 Antibodies) activators for further optimization.
mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (show NFE2L2 Antibodies), indicating that the presence of either Cys (show DNAJC5 Antibodies)-273 or Cys (show DNAJC5 Antibodies)-288 is sufficient for fish Keap1 molecules to fully function
study reports that the Keap1-Nrf2 (show NFE2L2 Antibodies) system comprises discrete sensor sites, including the Keap1 cysteines Cys (show DNAJC5 Antibodies)-151 and Cys (show DNAJC5 Antibodies)-273, for a variety of Nrf2 (show NFE2L2 Antibodies)-activating compounds
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
kelch-like ECH-associated protein 1
, cytosolic inhibitor of Nrf2
, kelch-like family member 19
, kelch-like protein 19
, NRF2 cytosolic inhibitor
, ring canal protein