Browse our anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) Antibodies

Full name:: anti-Kelch-Like ECH-Associated Protein 1 Antibodies (KEAP1)

On www.antibodies-online.com are 169 Kelch-Like ECH-Associated Protein 1 (KEAP1) Antibodies from 26 different suppliers available. Additionally we are shipping Kelch-Like ECH-Associated Protein 1 Kits (25) and Kelch-Like ECH-Associated Protein 1 Proteins (11) and many more products for this protein. A total of 221 Kelch-Like ECH-Associated Protein 1 products are currently listed.

Synonyms:: fb36f11, Inrf2, KEAP1, klhl19, mKIAA0132, wu:fb36f11, zgc:171654

list all antibodies	Gene Name	GeneID	UniProt
	KEAP1	9817	Q14145
	KEAP1	50868	Q9Z2X8
	KEAP1	117519
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Top referenced anti-Kelch-Like ECH-Associated Protein 1 Antibodies

Human Polyclonal KEAP1 Primary Antibody for IF (p), IHC (p) - ABIN702085 : Su, Zhang, Song, Shi, Fu, Xia, Bai, Hu, Xu, Song, Song: Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation. in Chemical research in toxicology 2015 (PubMed)
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Human Monoclonal KEAP1 Primary Antibody for ICC, FACS - ABIN1098137 : Kim, You, Lee, Ahn, Seong, Hwang: Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. in Cellular signalling 2010 (PubMed)
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Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN1098141 : Muscarella, Barbano, DAngelo, Copetti, Coco, Balsamo, la Torre, Notarangelo, Troiano, Parisi, Icolaro, Catapano, Valori, Pellegrini, Merla, Carella, Fazio, Parrella: Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. in Epigenetics 2011 (PubMed)
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Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN2724101 : Mercado, Kizawa, Ueda, Xiong, Kimura, Moses, Curtis, Ito, Barnes: Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers. in PLoS ONE 2014 (PubMed)
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Human Polyclonal KEAP1 Primary Antibody for WB - ABIN3043275 : Deng, Zhu, Mi, Xu, Jiao, Li, Xu, Liu, Xu: Melatonin antagonizes Mn-induced oxidative injury through the activation of keap1-Nrf2-ARE signaling pathway in the striatum of mice. in Neurotoxicity research 2015 (PubMed)
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Human Polyclonal KEAP1 Primary Antibody for WB - ABIN3043126 : Ni, Wang, Qiu, Pang, Song, Guo: Bone marrow mesenchymal stem cells protect against bleomycin-induced pulmonary fibrosis in rat by activating Nrf2 signaling. in International journal of clinical and experimental pathology 2016 (PubMed)
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Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN4328597 : Licht-Mayer, Wimmer, Traffehn, Metz, Brück, Bauer, Bradl, Lassmann: Cell type-specific Nrf2 expression in multiple sclerosis lesions. in Acta neuropathologica 2015 (PubMed)
Human Polyclonal KEAP1 Primary Antibody for ELISA, ICC - ABIN6262767 : Xiang, Ye, Huang, Yu, Chen, Deng, Zhang, Lou, Zhang, Shi, Chen, Zhou: Brusatol Enhances the Chemotherapy Efficacy of Gemcitabine in Pancreatic Cancer via the Nrf2 Signalling Pathway. in Oxidative medicine and cellular longevity 2018 (PubMed)
Cow (Bovine) Polyclonal KEAP1 Primary Antibody for IHC, WB - ABIN2775979 : Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006 (PubMed)
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Human Polyclonal KEAP1 Primary Antibody for ELISA, IHC - ABIN4328595 : Dinkova-Kostova, Talalay, Sharkey, Zhang, Holtzclaw, Wang, David, Schiavoni, Finlayson, Mierke, Honda: An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1. in The Journal of biological chemistry 2010 (PubMed)

More Antibodies against Kelch-Like ECH-Associated Protein 1 Interaction Partners

Human Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

Aberrant Nrf2 (show GABPA Antibodies)/Keap1 system integrity may affect self-defence mechanisms against oxidative stress in primary biliary cholangitis.
this study shows changes of KEAP1 expression levels induced by cell-free DNA in different cell types
Here we present a proof-of-concept application for the rational design of an epitope-specific antibody binding with the target protein Keap1, by grafting pre-defined structural interaction patterns from the native binding partner protein, Nrf2 (show GABPA Antibodies), onto geometrically matched positions of a set of antibody scaffolds. The designed antibodies bind to Keap1 and block the Keap1-Nrf2 (show GABPA Antibodies) interaction in an epitope-specific way
our study emphasizes the discovery of a gene signature regulated by the KEAP1-NRF2 (show GABPA Antibodies)-CUL3 (show CUL3 Antibodies) axis which is strongly associated with tumorigenesis and drug resistance in head and neck squamous cell cancer .
In the present review we briefly introduce the Nrf2 (show GABPA Antibodies)-Keap1 system and describe Nrf2 (show GABPA Antibodies) functions, illustrate the Nrf2 (show GABPA Antibodies)-NF-kappaB (show NFKB1 Antibodies) cross-talk, and highlight the effects of the Nrf2 (show GABPA Antibodies)-Keap1 system in the physiology and pathophysiology of striated (show NSDHL Antibodies) muscle tissue taking into account its role(s) in oxidative stress and reductive stress
Results show that KEAP1 expression in esophageal squamous cell carcinoma is regulated by miR (show MLXIP Antibodies)-432-3p that binds directly its 3'UTR (show UTS2R Antibodies).
An intact complex of PGAM5 (show PGAM5 Antibodies)-KEAP1-Nrf2 (show GABPA Antibodies) preserves mitochondrial motility by suppressing dominant-negative KEAP1 activity.
Hydrogen sulfide (show SQRDL Antibodies) attenuates vascular smooth muscle cell calcification in vitro via the KEAP1-NRF2 (show GABPA Antibodies) redox sensing/stress response system by enhancing NQO1 (show NQO1 Antibodies) expression.
Keap1 silencing in melanocytes induced melanogenesis and the expression of melanogenesis-associated molecules through HO-1 (show HMOX1 Antibodies)-associated beta-catenin (show CTNNB1 Antibodies) activation. Keap1 downregulation in melanocytes is important for cell proliferation and survival.
itaconate alkylates cysteine residues 151, 257, 288, 273 and 297 on the protein KEAP1, enabling Nrf2 (show GABPA Antibodies) to increase the expression of downstream genes with anti-oxidant and anti-inflammatory capacities

Mouse (Murine) Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

Renal tubular deletion of Keap1 promotes nephrogenic diabetes insipidus (show AVPR2 Antibodies) features, confirming that Nrf2 (show NFE2L2 Antibodies) activation in developing tubular cells causes a water reabsorption defect.
By inhibiting binding of Keap1 to Nrf2 (show NFE2L2 Antibodies).
these studies are the first to demonstrate that Brain ischemic preconditioning protects the blood-brain barrier against ischemic injury by generation of endogenous electrophiles and activation of the Nrf2 (show NFE2L2 Antibodies) pathway through inhibition of Keap1- and GSK3beta-dependent Nrf2 (show NFE2L2 Antibodies) degradation.
these results suggested that trehalose can function as a novel activator of the p62 (show GTF2H1 Antibodies)-Keap1/Nrf2 (show NFE2L2 Antibodies) pathway, in addition to inducing autophagy. Therefore, trehalose may be useful to treat many chronic diseases involving oxidative stress and dysfunction of autophagy.
While injury tended to suppress these genes in wild-type mice, the suppression was attenuated or reversed in Keap1 hypomorphs, suggesting that protection in these mice was mediated by increased Nrf2 (show NFE2L2 Antibodies) transcriptional activity.
These findings suggest that Keap1-Nrf2 (show NFE2L2 Antibodies) system plays a key role in depression and that dietary intake of sulforaphane-rich food during juvenile stages and adolescence can confer stress resilience in adulthood.
these results indicated that inactivation of KEAP1 protein by epigallocatechin gallate may mediate epigallocatechin gallate function in activating NRF2 (show NFE2L2 Antibodies)
the incidence, multiplicity and burden of Cutaneous squamous cell carcinomas that form in Keap1(flox/flox)/Nrf2 (show NFE2L2 Antibodies)(-/-) mice are much greater than in their Keap1(flox/flox)/Nrf2 (show NFE2L2 Antibodies)(+/+) counterparts, establishing Nrf2 (show NFE2L2 Antibodies) activation as the protection mediator.
The p62 (show GTF2H1 Antibodies)-keap1-Nrf2 (show NFE2L2 Antibodies) antioxidant pathway was primarily activated in the early stage of APAP hepatotoxicity.
Keap1 deletion in renal tubular cells results in an abnormal kidney development consistent with hydronephrosis.

Zebrafish Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1, disrupting the Keap1-Nrf2 (show NFE2L2 Antibodies) complex, thereby liberating and activating Nrf2 (show NFE2L2 Antibodies). Our findings of natural product-derived Nrf2 (show NFE2L2 Antibodies) activators lead to design options of potent Nrf2 (show NFE2L2 Antibodies) activators for further optimization.
mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (show NFE2L2 Antibodies), indicating that the presence of either Cys (show DNAJC5 Antibodies)-273 or Cys (show DNAJC5 Antibodies)-288 is sufficient for fish Keap1 molecules to fully function
study reports that the Keap1-Nrf2 (show NFE2L2 Antibodies) system comprises discrete sensor sites, including the Keap1 cysteines Cys (show DNAJC5 Antibodies)-151 and Cys (show DNAJC5 Antibodies)-273, for a variety of Nrf2 (show NFE2L2 Antibodies)-activating compounds

Cow (Bovine) Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

the potency of 15d-PGJ2 as a signalling molecule (show GDF5 Antibodies) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin

Kelch-Like ECH-Associated Protein 1 (KEAP1) Antigen Profile

Antigen Summary

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Alternative names and synonyms associated with Kelch-Like ECH-Associated Protein 1 (KEAP1)

kelch like ECH associated protein 1 (KEAP1) antibody
kelch-like ECH-associated protein 1 (Keap1) antibody
Kelch-like ECH-associated protein 1 (Keap1) antibody
kelch-like ECH-associated protein 1a (keap1a) antibody
kelch like ECH associated protein 1 (keap1) antibody
kelch like ECH associated protein 1 L homeolog (keap1.L) antibody
kelch like ECH associated protein 1 (Keap1) antibody
kelch-like ECH-associated protein 1b (keap1b) antibody

fb36f11 antibody
Inrf2 antibody
KEAP1 antibody
klhl19 antibody
mKIAA0132 antibody
wu:fb36f11 antibody
zgc:171654 antibody

Protein level used designations for KEAP1

cytosolic inhibitor of Nrf2 , kelch-like family member 19 , kelch-like protein 19 , NRF2 cytosolic inhibitor , ring canal protein , kelch-like ECH-associated protein 1 , klhl19 , LOW QUALITY PROTEIN: kelch-like ECH-associated protein 1

GENE ID	SPECIES
9817	Homo sapiens
50868	Mus musculus
117519	Rattus norvegicus
321837	Danio rerio
455706	Pan troglodytes
476713	Canis lupus familiaris
493386	Xenopus (Silurana) tropicalis
496326	Xenopus laevis
532791	Bos taurus
100136900	Sus scrofa
100173389	Pongo abelii
100346935	Oryctolagus cuniculus
100713871	Cavia porcellus
100003679	Danio rerio
101113845	Ovis aries musimon

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Show all anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) Antibodies with Pubmed References