Browse our anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) Antibodies

Human Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

1. Study characterize the interaction of Keap1, a central antioxidant response regulator in Metazoa, with the replicative helicase subunit protein MCM3. Analysis suggests that structural determinants of the interaction of Keap1 with its critical downstream target - Nrf2 master transactivator of oxidative stress response genes - may have evolved in evolution to mimic the conserved helix-2-insert motif of MCM3.

2. The HBXIP-mediated reduction in NRF2-KEAP1 complexes promotes NRF2 accumulation.

3. The Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (KEAP1-NRF2) signaling provides a cell protection mechanism against oxidative insults when endogenous stress defense mechanisms are imbalanced.

4. Identified mutations in KEAP1 associated with Nrf2 overexpression in papillary thyroid carcinoma. Mutations favored disruption of inhibitory interaction Nrf2-Keap1 to enable increased antioxidant Nrf2 activity, possibly with prognostic consequences.

5. Data indicate that transcription factor transcription factor 7-like 1 (TCF7L1) could regulate antioxidant response in gastric cancer cells by regulating Keap1/NRF2 [Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2] pathway.

6. to differences in relative orientation within this complex. The observed CGA isomer-specific affinity for CQA to activate Nrf2 signaling was confirmed by nuclear translocation of Nrf2 induced by CGA and greater (p < 0.05) upregulation of genes related to Nrf2 expression.

7. The KEAP1 R320Q and R470C ANCHOR mutants colocalize with NRF2, p62/SQSTM1, and polyubiquitin.

8. Data indicate that kelch-Like ECH-associated protein 1 (KEAP1)/nuclear factor (erythroid-derived 2)-like 2 protein (NRF2)-mutant lung cancer is a microenvironmentally distinct, biologically heterogeneous, and clinically underestimated disease.

9. Association of genetic alteration in KEAP1 with a variety of human diseases (review).

10. results demonstrate the existence of direct inter-pathway communication between glycolysis and the KEAP1-NRF2 transcriptional axis, provide insight into the metabolic regulation of the cellular stress response, and suggest a therapeutic strategy for controlling the cytoprotective antioxidant response in several human diseases

11. These results suggest that Keap1 is involved in the degradation of structural destabilized IKKbeta and negative regulation of NF-kappaB under proteotoxic stress.

12. KEAP1 single nucleotide polymorphism rs1048290 was associated with chronic obstructive pulmonary disease.

13. it was found that a potential phosphorylation of S53 affected Keap1-Nrf2 binding in the pull-down assay, and induced nuclear translocation of Nrf2 in the electrophoretic mobility shift assay.

14. Results found that KEAP1 mutation was exclusively present in PILAR1 expressing lung Adenocarcinoma (LUAD) samples.

15. Cytoplasmic Keap1 expression indicates poor prognosis in endometrial cancer

16. Frequency of CD69 and IL-10 positive cells in highly enriched KEAP1-edited regulatory T cells.

17. NRF1 is more stable in KEAP1(+/+) than in KEAP1(-/-) isogenic cell lines, whereas NRF2 is dramatically stabilized in KEAP1(-/-) cells.

18. Results demonstrate that Keap1 stabilizes F-actin cytoskeleton structures and inhibits focal adhesion turnover, thereby restraining the migration and invasion of NSCLC.

19. Keap1 protein expression in the esophageal squamous cell carcinoma.Aberrant signaling via the Keap1-Nrf2 pathway was common in esophageal squamous cell carcinoma and was associated with response and survival after chemoradiotherapy.

20. KEAP1 amplification is associated with the risk of lung metastasis in osteosarcoma.

Mouse (Murine) Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

1. Study characterize the interaction of Keap1, a central antioxidant response regulator in Metazoa, with the replicative helicase subunit protein MCM3. Analysis suggests that structural determinants of the interaction of Keap1 with its critical downstream target - Nrf2 master transactivator of oxidative stress response genes - may have evolved in evolution to mimic the conserved helix-2-insert motif of MCM3.

2. DC32 significantly suppressed rheumatoid arthritis (RA) via the Nrf2-p62-Keap1 feedback loop.

3. miR-1225 is significant in multiple malignancies and other pathological reactions; transfection of a miR-1225 mimic or Keap1 silencing inhibits osteoclastogenesis; after miR-1225 inhibition and Keap1 overexpression, TNF was increased; TNFalpha overexpression promoted Keap1 depletion-inhibited BMM osteoclastogenesis; miR-1225 activates Keap1-Nrf2-HO-1 signal to inhibit TNFalpha-induced osteoclastogenesis

4. Silencing Keap1 was able to reverse the inhibitory effect of Axitinib and enhance the protein expressions of Nrf2, NAD(P)H dehydrogenase [quinone] 1 and heme oxygenase 1.

5. This study showed that the KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy.

6. Keap1 possesses a Zn(2+) sensor whose triggering distorts its structure in a fashion that inhibits ubiquitylation of Nrf2 upon CRL(Keap1).

7. These results suggest that Keap1 is involved in the degradation of structural destabilized IKKbeta and negative regulation of NF-kappaB under proteotoxic stress.

8. The results from this study suggest a novel function of miR-24-3p in protecting cardiomyocytes from ischemia/reperfusion injury by the activation of the Nrf2-Keap1 pathway.

9. Nrf2 activation by Keap1 deletion concomitant with K-ras activation cause pancreatic atrophy.

10. Cold exposure induced cardiac injury by inhibiting the Nrf2-Keap1 signaling pathway.

11. Nrf2/Keap1 system regulates VSMC apoptosis during neointimal formation, thereby inhibiting neointimal hyperplasia after a vascular injury.

12. Renal tubular deletion of Keap1 promotes nephrogenic diabetes insipidus features, confirming that Nrf2 activation in developing tubular cells causes a water reabsorption defect.

13. By inhibiting binding of Keap1 to Nrf2.

14. these studies are the first to demonstrate that Brain ischemic preconditioning protects the blood-brain barrier against ischemic injury by generation of endogenous electrophiles and activation of the Nrf2 pathway through inhibition of Keap1- and GSK3beta-dependent Nrf2 degradation.

15. these results suggested that trehalose can function as a novel activator of the p62-Keap1/Nrf2 pathway, in addition to inducing autophagy. Therefore, trehalose may be useful to treat many chronic diseases involving oxidative stress and dysfunction of autophagy.

16. While injury tended to suppress these genes in wild-type mice, the suppression was attenuated or reversed in Keap1 hypomorphs, suggesting that protection in these mice was mediated by increased Nrf2 transcriptional activity.

17. These findings suggest that Keap1-Nrf2 system plays a key role in depression and that dietary intake of sulforaphane-rich food during juvenile stages and adolescence can confer stress resilience in adulthood.

18. these results indicated that inactivation of KEAP1 protein by epigallocatechin gallate may mediate epigallocatechin gallate function in activating NRF2

19. the incidence, multiplicity and burden of Cutaneous squamous cell carcinomas that form in Keap1(flox/flox)/Nrf2(-/-) mice are much greater than in their Keap1(flox/flox)/Nrf2(+/+) counterparts, establishing Nrf2 activation as the protection mediator.

20. The p62-keap1-Nrf2 antioxidant pathway was primarily activated in the early stage of APAP hepatotoxicity.

Zebrafish Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

1. These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1, disrupting the Keap1-Nrf2 complex, thereby liberating and activating Nrf2. Our findings of natural product-derived Nrf2 activators lead to design options of potent Nrf2 activators for further optimization.

2. mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2, indicating that the presence of either Cys-273 or Cys-288 is sufficient for fish Keap1 molecules to fully function

3. study reports that the Keap1-Nrf2 system comprises discrete sensor sites, including the Keap1 cysteines Cys-151 and Cys-273, for a variety of Nrf2-activating compounds

Cow (Bovine) Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

1. the potency of 15d-PGJ2 as a signalling molecule in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin