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anti-Mouse (Murine) NUF2 Antibodies:
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Human Polyclonal NUF2 Primary Antibody for IF, WB - ABIN2452061
Wigge, Kilmartin: The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. in The Journal of cell biology 2001
Show all 3 Pubmed References
Human Polyclonal NUF2 Primary Antibody for IF (p), IHC (p) - ABIN872897
Tokuzumi, Fukushima, Miyashita, Nakahara, Kubo, Yamashita, Harada, Nakamura, Kajihara, Jinnin, Ihn: Cell division cycle-associated protein 1 as a new melanoma-associated antigen. in The Journal of dermatology 2016
Nuf2 is a critical regulator of meiotic cell cycle progression in mammalian oocytes.
CDCA1 could be a prognostic marker in malignant melanoma patients.
Results provide evidence that CDCA1 plays a significant role in oral cavity carcinoma (OCC) tumorigenesis. Importantly, CDCA1 is associated with growth and survival of OCC cells where its elevated expression issignificantly associated with poor prognosis .
NUF2 modulates cell proliferation via cell cycle control in osteosarcoma Saos-2 cells.
found LncRNA AF339813 was positively regulated by NUF2
NUF2 silencing by RANi (RNA interference) reduced the proliferation and colony formation ability of pancreatic cancer cells in vitro.
NUF2 plays a critical role in the regulation of HCC cell proliferation and apoptosis.
NUF2 was overexpressed in glioma tissues and differentially expressed in a series of glioma cell lines. Depletion of NUF2 by short-hairpin RNA inhibited cell growth in vitro and in vivo.
hnRNP K binds to the promoter region of NUF2 and activates its transcription.
These results suggest that CDCA1 could be a prognostic biomarker and a potential therapeutic target for colorectal cancers .
these findings demonstrated that three buried glutamic acid-lysine pairs, in concert with hydrophobic interactions of core residues, provide the major specificity and stability requirements for Hec1-Nuf2 dimerization
NDC80, NUF2 and PTN were significantly aberrantly overexpressed in serous adenocarcinomas.
These data suggest that the CH and tail domains of Hec1 generate essential contacts between kinetochores and microtubules in cells, whereas the Nuf2 CH domain does not.
cell growths of colorectal and gastric cancers after the siRNA-mediated knockdown of either CDCA1 or KNTC2 were significantly suppressed.
Data highlight a specific role for hNuf2 in kinetochore-microtubule attachment and suggest that hNuf2 is part of a molecular linker between the kinetochore attachment site and tubulin subunits within the lattice of attached plus ends.
NUF2 is a core component of the kinetochore outer plate essential for organizing microtubule attachment sites.
the Spc24, Spc25, Nuf2, and Ndc80/Hec1 complex is a faithful copy of the endogenous Ndc80 complex
HsNUF2 and CENP-E are required for organization of stable microtubule-kinetochore attachment that is essential for faithful chromosome segregation in mitosis
CDCA1 may therefore be an ideal tumor-associated antigen useful for the diagnosis and immunotherapy of these cancer
alternative splicing variants, M-RIP, HYAL2, CDCA1, and MSMB genes showed differential expressions between cancer cells and corresponding normal tissues.
Chromosome congression in HSET + hNuf2 co-depleted cells required the plus-end directed motor CENP-E , which has been implicated in the gliding of mono-oriented kinetochores alongside adjacent K-fibres.
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.
cell division cycle associated 1
, cell division cycle-associated protein 1
, kinetochore protein Nuf2
, NUF2, NDC80 kinetochore complex component, homolog
, cancer/testis antigen 106
, un-named hi2769
, unm hi2769
, NMS complex subunit nuf2
, Cell division cycle-associated protein 1-A
, cell division cycle-associated protein 1-A
, kinetochore protein Nuf2-A
, kinetochore spindle checkpoint protein Nuf2