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Browse our anti-PDI (P4HB) Antibodies

Full name:: anti-Prolyl 4-Hydroxylase, beta Polypeptide Antibodies (P4HB)

On www.antibodies-online.com are 271 Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) Antibodies from 29 different suppliers available. Additionally we are shipping PDI Kits (56) and PDI Proteins (47) and many more products for this protein. A total of 383 PDI products are currently listed.

Synonyms:: DSI, ERBA2L, ERp59, GIT, P4Hbeta, p55, p58, PDI, Pdia1, PDIR, PHDB, PO4DB, PO4HB, PROHB, Thbp

list all antibodies	Gene Name	GeneID	UniProt
	P4HB	5034	P07237
	P4HB	18453	P09103
	P4HB	25506	P04785
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Relevant Pathways for anti-PDI Antibodies

Lipid Metabolism

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Top referenced anti-PDI Antibodies

Cow (Bovine) Monoclonal PDI Primary Antibody for BP, ELISA - ABIN152676 : Courageot, Fenouillet, Bastiani, Miquelis: Intracellular degradation of the HIV-1 envelope glycoprotein. Evidence for, and some characteristics of, an endoplasmic reticulum degradation pathway. in European journal of biochemistry 1999 (PubMed)
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Hamster Monoclonal PDI Primary Antibody for ICC, FACS - ABIN269364 : Jun, Lee, Song, Mansfield, Chou: G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis. in Blood 2011 (PubMed)
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Cow (Bovine) Polyclonal PDI Primary Antibody for ICC, IF - ABIN361829 : Na, Park, Jang, Cho, Lee, Kang, Lee, Bae, Park: Protein disulfide isomerase is cleaved by caspase-3 and -7 during apoptosis. in Molecules and cells 2007 (PubMed)
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Human Polyclonal PDI Primary Antibody for ELISA, WB - ABIN188849 : Uehara, Nakamura, Yao, Shi, Gu, Ma, Masliah, Nomura, Lipton: S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. in Nature 2006 (PubMed)
Cow (Bovine) Polyclonal PDI Primary Antibody for IHC, WB - ABIN2783246 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007 (PubMed)

More Antibodies against PDI Interaction Partners

Human Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) interaction partners

High P4HB expression is associated with colon cancer.
The cell surface trafficking of PDIA1, PDIA3, and PDIA6 is dependent on KDELR1, which travels in a dynamic manner to the cell surface. This transport is assumed to result in PDI cell surface association, which differs from PDI inducible secretion into the extracellular space.
Peroxynitrite preferentially oxidizes the dithiol redox motifs of protein-disulfide isomerase.
Overexpression of HIF-1alpha and P4HB is associated with poor prognosis in patients with gastric cancer.
Study demonstrated that the expression of P4HB is frequently upregulated at the mRNA and protein levels in diffuse gliomas. Its high expression was significantly correlated with high Ki-67, more TP53 mutations and poor survival outcome. These findings imply that high expression of P4HB plays an important role in diffuse glioma progression.
identify a potent and selective PDIA1 inhibitor, KSC-34, with 30-fold selectivity for the a site over the a' site. KSC-34 displays time-dependent inhibition of PDIA1 reductase activity in vitro with a kinact/ KI of 9.66 x 10(3) M(-1) s(-1) and is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins.
P4HB promotes hepatocellular carcinoma progression by down-regulating GRP78 expression and subsequently promoting epithelial-to-mesenchymal transition.
analysis of antiplatelet activity of CxxC through binding to Cys400 in the PDI a0 domain, which can be further exploited as a model for sitedriven antithrombotic agent development
Current findings indicate that thiol isomerase-mediated disulfide bond modification in receptors and plasma proteins is an important layer of control of thrombosis and vascular function more generally.
DIA1 was robustly secreted by physiological levels of arterial laminar shear in endothelial cells and supported alpha 5 integrin thiol oxidation.
Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates.
a mechanism of dual Ero1alpha regulation by dynamic redox interactions between PDI and the two Ero1alpha flexible loops that harbor the regulatory cysteines.
analysis of how redox affects human protein disulfide isomerase regulate binding affinity of 17 beta-estradiol
These findings improve our understanding of PDI-protected aggregation of wild-type alpha-Syn and its H50Q familial mutant.
Association of P4HB polymorphisms with sporadic amyotrophic lateral sclerosis susceptibility in the Chinese Han population.
the effect of the endoplasmic reticulum chaperone protein disulfide isomerase (PDI) on beta-cell dysfunction, was examined.
Amyotrophic lateral sclerosis-linked PDIA1 mutations disrupt motor neuron connectivity.
direct binding of PDIA1 to VWF, is reported.
Selective sequestration of PDI1A in a calcium depletion-mediated complex with the abundant chaperone calreticulin attenuates the effective concentration of this major lumenal thiol oxidant.
Cole-Carpenter syndrome is caused by a specific de novo mutation in P4HB that impairs the disulfide isomerase activity of protein disulfide isomerase.

Mouse (Murine) Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) interaction partners

these results suggest that overexpression of PDI may protect transplanted cells from hypoxia and other possibly occurring endoplasmic reticulum stresses, and consequently enhance their regenerative properties.
Neutrophil surface PDI is important for alphaMbeta2 integrin-mediated adhesion of human neutrophils under shear and static conditions and for binding of soluble fibrinogen to activated alphaMbeta2 integrin.
Unfolded protein response caused by protein misfolding, may lead to PDI-dependent NOX activation and contribute to neurotoxicity in neurodegenerative diseases including ALS.
These results indicate that both endothelial and platelet beta3 integrins contribute to extracellular PDI binding at the vascular injury site.
PDI from endothelial cells is required for fibrin generation in vivo.
Protein disulfide isomerase (PDI) on the platelet surface is recognized by anti-dengue virus NS1 antibodies.

Cow (Bovine) Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) interaction partners

Rotavirus-protein disulfide isomerase interaction was demonstrated in vitro as well as inMA104 cells and intestinal villi from suckling mice.

PDI (P4HB) Antigen Profile

Antigen Summary

This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.

Alternative names and synonyms associated with PDI (P4HB)

prolyl 4-hydroxylase subunit beta (P4HB) antibody
prolyl 4-hydroxylase, beta polypeptide (P4hb) antibody
prolyl 4-hydroxylase subunit beta (P4hb) antibody
prolyl 4-hydroxylase, beta polypeptide (P4HB) antibody
prolyl 4-hydroxylase subunit beta L homeolog (p4hb.L) antibody
protein disulfide-isomerase (LOC8281065) antibody

DSI antibody
ERBA2L antibody
ERp59 antibody
GIT antibody
P4Hbeta antibody
p55 antibody
p58 antibody
PDI antibody
Pdia1 antibody
PDIR antibody
PHDB antibody
PO4DB antibody
PO4HB antibody
PROHB antibody
Thbp antibody

Protein level used designations for P4HB

, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , cellular thyroid hormone-binding protein collagen prolyl 4-hydroxylase beta glutathione-insulin transhydrogenase p55 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide prolyl 4-hydroxylase subunit beta protein disulfide isomerase family A, member 1 protein disulfide isomerase-associated 1 protein disulfide isomerase/oxidoreductase protein disulfide-isomerase protocollagen hydroxylase thyroid hormone-binding protein p55 ER protein 59 endoplasmic reticulum resident protein 59 protein disulfide isomerase Protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide) PDI (E.C.5.3.4.1) cellular thyroid hormone binding protein prolyl 4-hydroxylase beta polypeptide prolyl 4-hydroxylase, beta subunit Cellular thyroid hormone-binding protein Prolyl 4-hydroxylase subunit beta multifunctional thyroid hormone binding protein PDI R-cognin procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase-associated 1) procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55) retina cognin protein disulphide isomerase PDI p58 prolyl 4-hydroxylase, beta polypeptide

GENE ID	SPECIES
5034	Homo sapiens
18453	Mus musculus
25506	Rattus norvegicus
281373	Bos taurus
100328595	Oryctolagus cuniculus
454970	Pan troglodytes
100173809	Pongo abelii
399248	Xenopus laevis
374091	Gallus gallus
100733944	Cavia porcellus
483369	Canis lupus familiaris
8281065	Ricinus communis
100689433	Cricetulus griseus

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Show all anti-Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) Antibodies with Pubmed References