Protein Summary

This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.

Alternative names and synonyms associated with PDI (P4HB)

• prolyl 4-hydroxylase subunit beta (P4HB) antibody
• prolyl 4-hydroxylase, beta polypeptide (P4hb) antibody
• prolyl 4-hydroxylase subunit beta (P4hb) antibody
• prolyl 4-hydroxylase, beta polypeptide (P4HB) antibody
• prolyl 4-hydroxylase subunit beta L homeolog (p4hb.L) antibody
• Show all gene names
• protein disulfide-isomerase (LOC8281065) antibody

• DSI antibody
• ERBA2L antibody
• ERp59 antibody
• GIT antibody
• P4Hbeta antibody
• Show all synonym aliases
• p55 antibody
• p58 antibody
• PDI antibody
• Pdia1 antibody
• PDIR antibody
• PHDB antibody
• PO4DB antibody
• PO4HB antibody
• PROHB antibody
• Thbp antibody

Protein level used designations for P4HB

cellular thyroid hormone-binding protein , collagen prolyl 4-hydroxylase beta , glutathione-insulin transhydrogenase , p55 , procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide , prolyl 4-hydroxylase subunit beta , protein disulfide isomerase family A, member 1 , protein disulfide isomerase-associated 1 , protein disulfide isomerase/oxidoreductase , protein disulfide-isomerase , protocollagen hydroxylase , thyroid hormone-binding protein p55 , ER protein 59 , endoplasmic reticulum resident protein 59 , protein disulfide isomerase , Protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide) , PDI (E.C.5.3.4.1) , cellular thyroid hormone binding protein , prolyl 4-hydroxylase beta polypeptide , prolyl 4-hydroxylase, beta subunit , Cellular thyroid hormone-binding protein , Prolyl 4-hydroxylase subunit beta , multifunctional thyroid hormone binding protein , PDI , R-cognin , procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase-associated 1) , procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55) , retina cognin , protein disulphide isomerase PDI , p58 , prolyl 4-hydroxylase, beta polypeptide