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Human Monoclonal BCL2 Primary Antibody for ICC, IHC (fro) - ABIN3044481
Jiang, Li, Zhou, Wang, Zhang, Wang: Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways. in International journal of molecular medicine 2014
Show all 91 Pubmed References
Human Polyclonal BCL2 Primary Antibody for ELISA, WB - ABIN3042814
Zong, Li, Lin, Hou, Ma: Lipoxin A4 pretreatment mitigates skeletal muscle ischemia-reperfusion injury in rats. in American journal of translational research 2017
Show all 79 Pubmed References
Human Polyclonal BCL2 Primary Antibody for IF, IHC (p) - ABIN388095
Zheng, Zhou, Ye, Li, Bai, Zhang: The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells. in World journal of surgical oncology 2010
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Human Polyclonal BCL2 Primary Antibody for IF (p), IHC (p) - ABIN707156
Wang, Ma, Su: NF-?B pathway contributes to cadmium-induced apoptosis of porcine granulosa cells. in Biological trace element research 2013
Show all 7 Pubmed References
Dog (Canine) Polyclonal BCL2 Primary Antibody for IHC, IHC (p) - ABIN4283360
Chopra, Ray, Dwivedi, Tiwari, Singh, Singh, Kushwaha, Jahan, Pandey, Gupta, Chaturvedi, Pant, Ray, Gupta: Photoprotective efficiency of PLGA-curcumin nanoparticles versus curcumin through the involvement of ERK/AKT pathway under ambient UV-R exposure in HaCaT cell line. in Biomaterials 2016
Show all 6 Pubmed References
Human Monoclonal BCL2 Primary Antibody for ICS - ABIN1177234
Deng, Xiao, Lang, Gao, Ruvolo, May: Novel role for JNK as a stress-activated Bcl2 kinase. in The Journal of biological chemistry 2001
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Human Monoclonal BCL2 Primary Antibody for ICS - ABIN1177233
Maundrell, Antonsson, Magnenat, Camps, Muda, Chabert, Gillieron, Boschert, Vial-Knecht, Martinou, Arkinstall: Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1. in The Journal of biological chemistry 1997
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Human Monoclonal BCL2 Primary Antibody for FACS, ICC - ABIN638444
Soilu-Hänninen, Ekert, Bucci, Syroid, Bartlett, Kilpatrick: Nerve growth factor signaling through p75 induces apoptosis in Schwann cells via a Bcl-2-independent pathway. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
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Human Monoclonal BCL2 Primary Antibody for IP, IHC - ABIN222984
Cordiali-Fei, Ardigo, Mastroianni, Giuliani, D Agosto, Bordignon, Trento, Vento, Berardesca: Serum cytokines and biohumoral immunological characterization of psoriatic patients in long term etanercept treatment. in International journal of immunopathology and pharmacology 2008
Show all 6 Pubmed References
Human Polyclonal BCL2 Primary Antibody for ELISA, WB - ABIN268671
Pachori, Melo, Zhang, Solomon, Dzau: Chronic recurrent myocardial ischemic injury is significantly attenuated by pre-emptive adeno-associated virus heme oxygenase-1 gene delivery. in Journal of the American College of Cardiology 2006
Show all 4 Pubmed References
Bcl-2 binding to ARTS involves the BH3 domain of Bcl-2. Lysine 17 in Bcl-2 serves as the main acceptor for ubiquitylation, and a Bcl-2 K17A mutant has increased stability and is more potent in protection against apoptosis.
The expression levels of miR (show MLXIP Antibodies)-204-5p were downregulated in prostate cancer cells compared with normal prostate epithelial cells. BCL2 mRNA and protein expression decreased in miR (show MLXIP Antibodies)-204-5p-transfected cells, which led to cytochrome C (show CYCS Antibodies) release from mitochondria. Cotransfection of a reporter vector harboring the BCL2 3'-untranslated region to compete with endogenous transcripts partially rescued miR (show MLXIP Antibodies)-204-5p-induced apoptosis.
GATA4 (show GATA4 Antibodies) was a transcription factor that activated mouse double minute 2 homolog (MDM2 (show MDM2 Antibodies)) and B cell lymphoma 2 (BCL2) expression in ALL cells.
High BCL2 expression is associated with oncogenicity and chemoresistance in hepatocellular carcinoma.
Gastrin (show GAST Antibodies) and BCL2 apoptosis regulator (Bcl2) are highly expressed in gastric cancer tissues, and they are correlated with the clinicopathologic features.
This study utilized a lentiviral vector that overexpressed the human VEGF (show VEGFA Antibodies) and Bcl-2 genes simultaneously. Co-overexpression of VEGF (show VEGFA Antibodies) and Bcl-2 inhibits the oxygen glucose deprivation induced apoptosis of mesenchymal stem cells.
Double-hit lymphoma (DHL) is an aggressive form of DLBCL with an unmet treatment need, in which MYC (show MYC Antibodies) rearrangement is present with either BCL2 or BCL6 (show BCL6 Antibodies) rearrangement
The expression of Bcl-2 and E cadherin (show CDH1 Antibodies) immunopositivity was associated positively with tumor grade, high T category and histopathological grades. The results of this study points to the significance of cell proliferation and invasion as a major determinant of prognosis in OSCC.
meta-analysis suggests a role BCL-2 promoter polymorphisms in cancer susceptibility and prognosis; rs2279115 was associated with higher risk of cancer susceptibility in Asia but not in Caucasian; rs2279115 was associated with a higher risk in digestive system cancer and endocrine system cancer but not breast cancer, respiratory cancer and hematopoietic cancer
In this study, we investigated whether APG (show SMAD1 Antibodies)-1252-12A inhibits the growth of five leukemia cell lines in a concentration- or time-dependent manner by MTS (show TIMM8A Antibodies) assay.APG-1252-12A is a Bcl-2 homology (BH)-3 mimetic that specifically binds to Bcl-2 and Bcl-xl (show BCL2L1 Antibodies), which has shown efficacy in some Bcl-2 dependent hematological cancers
The results suggest that SPK2 (show SPHK2 Antibodies) interacts with Bcl2 via its BH3 domain, thereby dissociating it from Beclin-1 (show BECN1 Antibodies) and activating autophagy while protecting neurons against ischemic injury.
The findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins, BCL2, Mcl1 (show MCL1 Antibodies), and BCL2A1 (show BCL2A1 Antibodies), rather than by a single anti-apoptotic protein.
Bcl-2 is strongly expressed in the inner hair cells and spiral ganglion neurons of young mice. In addition, moderate Bcl-2 expression is also detected in the outer hair cells and in the neurons of the auditory cortex. A significant reduction of Bcl-2 expression in the cochlea or auditory cortex is also associated with elevated hearing thresholds and hair cell loss during aging.
Bcl2 is the autophagy-related target of miR (show MLXIP Antibodies)-449a.
anti-apoptotic molecules BclxL (show BCL2L1 Antibodies) and Bcl-2 and the pro-apoptotic factors BAD and BID (show BID Antibodies) cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L (show FASL Antibodies).
Acute ethanol exposure induced autophagy-mediated heart toxicity and injury mainly through the ROS (show ROS1 Antibodies)-JNK (show MAPK8 Antibodies)-Bcl-2 signaling pathway.
Th17 cells are resistant to glucocorticoid-induced apoptosis and cytokine suppression, at least in part due to high levels of BCL-2. These findings support a role of Th17 cells in glucocorticoid-resistant inflammatory conditions such as certain endotypes of asthma.
E2 protects skeletal myoblasts against apoptosis induced by H2 O2 modulating p53 (show TP53 Antibodies) and FoxO (show FOXO3 Antibodies) transcription factors and then their target genes Bcl-2, Bim (show BCL2L11 Antibodies), Puma (show BBC3 Antibodies), PERP (show PERP Antibodies), and MDM2 (show MDM2 Antibodies), without affecting Noxa (show PMAIP1 Antibodies) gene.
Bcl-2 expression has a significant impact on the mineralogical content of enamel crystals of tooth structure
The results suggest that CARP (show ANKRD1 Antibodies) can protect against hypoxia-reperfusion induced cardiomyocyte apoptosis, possibly through increasing anti-apoptosis Bcl2 gene expression.
These results suggest a role for mitochondrial p53 (show TP53 Antibodies) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax (show BAX Antibodies) and Bcl2.
Zebrafish gene expressions of P53 (show TP53 Antibodies), Bcl-2, Bax (show BAX Antibodies) and caspase-3 (show CASP3 Antibodies) were elevated after exposure with microcystin-LR under different ambient temperatures.
Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1 (show S1PR1 Antibodies), and ICAM1 (show ICAM1 Antibodies) in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.
Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 (show COX2 Antibodies) and bcl2, but increased p53 (show TP53 Antibodies) expression.
Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 (show NOTCH1 Antibodies) and fish bcl-2, indicating synergy between the Notch (show NOTCH1 Antibodies) pathway and the bcl2-mediated antiapoptotic pathway.
Over-expression of STC-1 (show STC1 Antibodies) up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 (show CASP3 Antibodies) production in the damaged cells. Findings from this study suggest that STC-1 (show STC1 Antibodies) plays a protective role in intestinal cells through an antioxidant mechanism.
BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax (show BAX Antibodies) expression.
G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.
role of vascular endothelial growth factor receptor-1 (show FLT1 Antibodies) in Bcl-2 expression
apoptosis-inducing factor (show AIFM1 Antibodies) was expressed in luminal alveolar cells and, in concert with a change in bax (show BAX Antibodies) protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
mRNA expression of Bax (show BAX Antibodies), Bcl-2, caspase-3 (show CASP3 Antibodies) and-7 cannot be used as a reliable apoptosis detection method.
These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.
bcl-2 and bax (show BAX Antibodies) were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax (show BAX Antibodies)]
excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 (show CASP3 Antibodies) expression as well as low Bcl-2 expression.
These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax (show BAX Antibodies) ratio through a mechanism involving protein kinase C (show PKC Antibodies).
Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax (show BAX Antibodies) and decreasing expression of bcl2.
Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax (show BAX Antibodies).
Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 (show TP53 Antibodies) and decrease in the antiapoptotic BCl2 proteins.
Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3 (show CASP3 Antibodies).
Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
apoptosis regulator Bcl-2
, protein phosphatase 1, regulatory subunit 50
, B cell lymphoma 2 associated oncogene
, B-cell leukemia/lymphoma 2
, Bcl2-like protein
, BCL2B-cell CLL/lymphoma 2
, B-cell lymphoma protein 2
, B-cell CLL/lymphoma 2
, LOW QUALITY PROTEIN: apoptosis regulator Bcl-2
, Apoptosis regulator Bcl-2