Browse our anti-BCL2 (BCL2) Antibodies

Human B-Cell CLL/lymphoma 2 (BCL2) interaction partners

1. Permeabilisation of the mitochondrial outer membrane (MOMP) is directly regulated by the BCL-2 (B cell lymphoma 2) family in mammals [Review].

2. These results suggest that chlorogenic acid (CGA (show CGA Antibodies))suppresses hLECs apoptosis and prevents lens opacity (show MIP Antibodies) induced by H2O2 via Bax (show BAX Antibodies)/Bcl2 signaling pathway. CGA (show CGA Antibodies) may provide effective defenses against oxidative stress and, thus, has potential as treatment for a variety of diseases in clinical practice.

3. The present study demonstrated that TATfused inositol 1,4,5trisphosphate receptorderived peptide (TATIDPS), which targets the BH4 domain of Bcl2, increased cisplatininduced Ca2 (show CA2 Antibodies)+ flux from the endoplasmic reticulum (ER) into the cytosol and mitochondria.

4. we highlight the emerging recognition of MYC (show MYC Antibodies) and BCL2 coexpression as the most robust predictor of diffuse large B cell lymphoma outcome, and discuss rationally conceived experimental approaches to treat these high-risk patients.

5. Bcl-2 binding to ARTS involves the BH3 domain of Bcl-2. Lysine 17 in Bcl-2 serves as the main acceptor for ubiquitylation, and a Bcl-2 K17A mutant has increased stability and is more potent in protection against apoptosis.

6. The expression levels of miR (show MLXIP Antibodies)-204-5p were downregulated in prostate cancer cells compared with normal prostate epithelial cells. BCL2 mRNA and protein expression decreased in miR (show MLXIP Antibodies)-204-5p-transfected cells, which led to cytochrome C (show CYCS Antibodies) release from mitochondria. Cotransfection of a reporter vector harboring the BCL2 3'-untranslated region to compete with endogenous transcripts partially rescued miR (show MLXIP Antibodies)-204-5p-induced apoptosis.

7. GATA4 (show GATA4 Antibodies) was a transcription factor that activated mouse double minute 2 homolog (MDM2 (show MDM2 Antibodies)) and B cell lymphoma 2 (BCL2) expression in ALL cells.

8. High BCL2 expression is associated with oncogenicity and chemoresistance in hepatocellular carcinoma.

9. Gastrin (show GAST Antibodies) and BCL2 apoptosis regulator (Bcl2) are highly expressed in gastric cancer tissues, and they are correlated with the clinicopathologic features.

10. This study utilized a lentiviral vector that overexpressed the human VEGF (show VEGFA Antibodies) and Bcl-2 genes simultaneously. Co-overexpression of VEGF (show VEGFA Antibodies) and Bcl-2 inhibits the oxygen glucose deprivation induced apoptosis of mesenchymal stem cells.

Mouse (Murine) B-Cell CLL/lymphoma 2 (BCL2) interaction partners

1. MiR (show MLXIP Antibodies)-146a inhibits proliferation and induces apoptosis in murine osteoblastic MC3T3-E1 by regulating Bcl2

2. The data revealed that autophagy is an important regulator of osteoblastic apoptosis through its interaction with Bax (show BAX Antibodies)/Bcl2, and maintains the osteoblastic function of MC3T3E1 cells following GC exposure. In addition, these results indicated that the suppression of autophagy in OBs (show LEP Antibodies) under chronic GC therapy may increase the prevalence of GCinduced osteoporosis and fragility fractures.

3. Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53 (show TP53 Antibodies)/Bax (show BAX Antibodies) activation.

4. The results suggest that SPK2 (show SPHK2 Antibodies) interacts with Bcl2 via its BH3 domain, thereby dissociating it from Beclin-1 (show BECN1 Antibodies) and activating autophagy while protecting neurons against ischemic injury.

5. The findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins, BCL2, Mcl1 (show MCL1 Antibodies), and BCL2A1 (show BCL2A1 Antibodies), rather than by a single anti-apoptotic protein.

6. Bcl-2 is strongly expressed in the inner hair cells and spiral ganglion neurons of young mice. In addition, moderate Bcl-2 expression is also detected in the outer hair cells and in the neurons of the auditory cortex. A significant reduction of Bcl-2 expression in the cochlea or auditory cortex is also associated with elevated hearing thresholds and hair cell loss during aging.

7. Bcl2 is the autophagy-related target of miR (show MLXIP Antibodies)-449a.

8. anti-apoptotic molecules BclxL (show BCL2L1 Antibodies) and Bcl-2 and the pro-apoptotic factors BAD and BID (show BID Antibodies) cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L (show FASL Antibodies).

9. Acute ethanol exposure induced autophagy-mediated heart toxicity and injury mainly through the ROS (show ROS1 Antibodies)-JNK (show MAPK8 Antibodies)-Bcl-2 signaling pathway.

10. Th17 cells are resistant to glucocorticoid-induced apoptosis and cytokine suppression, at least in part due to high levels of BCL-2. These findings support a role of Th17 cells in glucocorticoid-resistant inflammatory conditions such as certain endotypes of asthma.

Zebrafish B-Cell CLL/lymphoma 2 (BCL2) interaction partners

1. These results suggest a role for mitochondrial p53 (show TP53 Antibodies) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax (show BAX Antibodies) and Bcl2.

2. Zebrafish gene expressions of P53 (show TP53 Antibodies), Bcl-2, Bax (show BAX Antibodies) and caspase-3 (show CASP3 Antibodies) were elevated after exposure with microcystin-LR under different ambient temperatures.

3. Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1 (show S1PR1 Antibodies), and ICAM1 (show ICAM1 Antibodies) in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.

4. Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 (show COX2 Antibodies) and bcl2, but increased p53 (show TP53 Antibodies) expression.

5. Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 (show NOTCH1 Antibodies) and fish bcl-2, indicating synergy between the Notch (show NOTCH1 Antibodies) pathway and the bcl2-mediated antiapoptotic pathway.

Cow (Bovine) B-Cell CLL/lymphoma 2 (BCL2) interaction partners

1. Over-expression of STC-1 (show STC1 Antibodies) up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 (show CASP3 Antibodies) production in the damaged cells. Findings from this study suggest that STC-1 (show STC1 Antibodies) plays a protective role in intestinal cells through an antioxidant mechanism.

2. BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax (show BAX Antibodies) expression.

3. G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.

4. role of vascular endothelial growth factor receptor-1 (show FLT1 Antibodies) in Bcl-2 expression

5. apoptosis-inducing factor (show AIFM1 Antibodies) was expressed in luminal alveolar cells and, in concert with a change in bax (show BAX Antibodies) protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses

6. mRNA expression of Bax (show BAX Antibodies), Bcl-2, caspase-3 (show CASP3 Antibodies) and-7 cannot be used as a reliable apoptosis detection method.

7. These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.

Guinea Pig B-Cell CLL/lymphoma 2 (BCL2) interaction partners

1. bcl-2 and bax (show BAX Antibodies) were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax (show BAX Antibodies)]

Rabbit B-Cell CLL/lymphoma 2 (BCL2) interaction partners

1. excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 (show CASP3 Antibodies) expression as well as low Bcl-2 expression.

2. These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax (show BAX Antibodies) ratio through a mechanism involving protein kinase C (show PKC Antibodies).

3. Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax (show BAX Antibodies) and decreasing expression of bcl2.

4. Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax (show BAX Antibodies).

5. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 (show TP53 Antibodies) and decrease in the antiapoptotic BCl2 proteins.

6. Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3 (show CASP3 Antibodies).

7. Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.