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anti-Human BCL2 Antibodies:
anti-Rat (Rattus) BCL2 Antibodies:
anti-Mouse (Murine) BCL2 Antibodies:
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Human Monoclonal BCL2 Primary Antibody for ICC, IHC (fro) - ABIN3044481
Jiang, Li, Zhou, Wang, Zhang, Wang: Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways. in International journal of molecular medicine 2014
Show all 145 Pubmed References
Human Polyclonal BCL2 Primary Antibody for ELISA, WB - ABIN3042814
Zong, Li, Lin, Hou, Ma: Lipoxin A4 pretreatment mitigates skeletal muscle ischemia-reperfusion injury in rats. in American journal of translational research 2017
Show all 137 Pubmed References
Human Polyclonal BCL2 Primary Antibody for WB - ABIN5518894
Xu, Yu, He, Li, Yu, Yu: Effects of garlicin on apoptosis in rat model of colitis. in World journal of gastroenterology 2005
Show all 87 Pubmed References
Human Polyclonal BCL2 Primary Antibody for ELISA, IHC - ABIN5693065
Bentley: Primary health care in northwestern Somalia: a case study. in Social science & medicine (1982) 1989
Show all 82 Pubmed References
Human Polyclonal BCL2 Primary Antibody for IF, IHC - ABIN6712055
Zhu, Shan, Wang, Shu, Liu: miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines. in International journal of cancer 2010
Show all 40 Pubmed References
Human Polyclonal BCL2 Primary Antibody for IHC, WB - ABIN6677123
Ge, Zhao, Wang, Li, Yu, He, Xue, Zhu, Zhang, Cheng, Jiang, Hu: iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding. in Cancer cell 2017
Show all 20 Pubmed References
Human Polyclonal BCL2 Primary Antibody for IHC, WB - ABIN6137496
Zhang, Qu, Lin, Wu, Chen, Wang, Zhou, Wei, Guo, Yao, He, Liu, Yang, Guan, Wang, Zhao, Liu, Zhao, Xu: Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients. in Nature communications 2017
Show all 20 Pubmed References
Human Polyclonal BCL2 Primary Antibody for ELISA, ICC - ABIN6260222
Zhang, Chen, Wang, Yang, Li, Wang, Liu, Ye: Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase. in Oncotarget 2018
Show all 17 Pubmed References
Dog (Canine) Polyclonal BCL2 Primary Antibody for IHC, IHC (p) - ABIN4283360
Chopra, Ray, Dwivedi, Tiwari, Singh, Singh, Kushwaha, Jahan, Pandey, Gupta, Chaturvedi, Pant, Ray, Gupta: Photoprotective efficiency of PLGA-curcumin nanoparticles versus curcumin through the involvement of ERK/AKT pathway under ambient UV-R exposure in HaCaT cell line. in Biomaterials 2016
Show all 8 Pubmed References
Human Polyclonal BCL2 Primary Antibody for IF (p), IHC (p) - ABIN707156
Wang, Ma, Su: NF-?B pathway contributes to cadmium-induced apoptosis of porcine granulosa cells. in Biological trace element research 2013
Show all 7 Pubmed References
Approximately 3% of all newly diagnosed chronic lymphocytic leukemia patients have either an IGH-BCL2 or IGH-BCL3 translocations.
The inhibition of AKT attenuated EYA2-induced Bcl-2 upregulation. In conclusion, our data demonstrated that Eya2 was upregulated in prostate cancers. EYA2 promotes cell proliferation and invasion as well as cancer progression by regulating docetaxel sensitivity and mitochondrial membrane potential, possibly via the AKT/Bcl-2 axis.
Study in rat xenograft model of renal clear cell carcinoma (RCCC) showed that expression of G250 had a certain correlation with the pathological changes of RCCC and expressions of Bax and Bcl-2 were up-regulated in the RCCC group compared to a healthy control. Results suggest G250 as a new specific marker of RCCC and joint detection of Bax and Bcl-2 can be used as an important index for the diagnosis of RCCC.
Sensitization and reversal of glioblastoma cells resistance to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism has been reported.
our results demonstrated that the interaction of Atg4B and Bcl-2 might play an important role in Cd-induced crosstalk between apoptosis and autophagy through disassociation of Bcl-2-Beclin1. Cd-induced autophagy is apoptosis-dependent and prevents apoptotic cell death to ensure the growth and proliferation of A549 cells.
People with bcl-2 gene locus 938 CC genotype in Hebei Provincewere more likely to suffer from the esophageal and gastric cardia adenocarcinoma.
There was a statistically significant correlation between mRNA of MYC and BCL2.
Results provide evidence that overexpression of BCL-2 protein is associated with a poor survival in patients with primary central nervous system diffuse large B-cell lymphoma.
Patients with juvenile dermatomyositis had increased sBcl-2, which correlated with CRP. Expression of Bcl-2 was increased and expression of Fas was decreased in CD3+, CD4+, and CD8+ T lymphocytes compared with juvenile idiopathic arthritis and/or healthy controls.
BCL2 levels are elevated in breast cancer where they are marker of good prognosis. BCL2 and active caspase levels correlate negatively; yet, active caspases indicate good outcome. Low BCL2 and low caspase-7 are highly prognostic of unfavourable outcome across all breast cancers. BCL2 levels indicate molecular subtype and tumour proliferation status in breast cancer.
KPT-330 treatment increased binding of Bcl-2 to Bim but was overcome by ABT-199 treatment, demonstrating that KPT-330 and ABT-199 reciprocally overcome apoptosis resistance. Mcl-1 knockdown and overexpression confirmed its critical role in the antileukaemic activity of the combination
Mechanistic investigation demonstrated that FSTL5 promoted Hepatocellular carcinoma (HCC) cell apoptosis in a caspase-dependent manner and regulated Bcl-2 family proteins. These results indicate that FSTL5 may be a potential novel target for HCC treatment, and a biomarker for tumor prognosis.
These pore-forming effector proteins share four Bcl-2 homology (BH) domains.
Study results indicate that TRAF3, perhaps by promoting exacerbated B cell responses to certain antigens, and BCL2, presumably by supporting survival of these clones, cooperate to induce mature B cell neoplasms in transgenic mice expressing human proteins. TRAF3 upregulation favors the production of V(H)DJ(H) rearrangements producing HCDR3 sequences similar to those recognizing PAMPs and DAMPs.
Review focuses on the relevance of BCL-2 for apoptosis modulation at the mitochondrial level, its potential as therapeutic target for hematological malignancies, and the results obtained with selective inhibitors belonging to the BH3-mimetics, especially venetoclax used in monotherapy or in combination with other agents.
High BCL2 expression is associated with MYC-positive diffuse large B-cell lymphoma.
IL-17A-inhibited autophagy is related to Bcl2 degradation in hepatocellular carcinoma (HCC) cells. Bcl2 may be degraded via the autophagosome-lysosome pathway in HCC cells.
Information on molecular markers obtained from immunohistochemical staining of prostate tissue, included B cell lymphoma-2 (bcl-2), p53, and microvessel density.
miR-15a modulation has potential implications in controlling various biological and pathogenic processes in colon carcinogenesis via targeting its downstream proteins such as BCL2 and SOX2
Gray matter structural covariance networks (SCNs) analysis and covariance strength interactions support the genetic influences of the Bcl-2 rs956572 functional polymorphism on the SCN in the early stage of Alzheimer's disease. Results show a greater genetic influence in the A homozygotes on the executive control network.
GIT1 interacted with Beclin1 and promoted Beclin1 phosphorylation at Thr119, which induced the disruption of Beclin1 and Bcl2 binding under starvation conditions, thereby, positively regulating autophagy. Taken together, the findings suggest a previously unappreciated role of GIT1 in autophagy of OCs during fracture repair
the findings of this study demonstrate that Nur77 is involved in the cigarette smoke extract induced autophagic death of lung cells, and that this process is partially dependent on the increased interaction between Nur77 and Bcl2, and on the dissociation of Bcl2 from Beclin1.
Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid protein that is found predominantly in the heart.
These results establish crucial residues in Bcl-2 required for Nur77/Nor-1-mediated apoptosis and point to potential new strategies for manipulating Bcl-2 function.
6 months of aerobic exercise can effectively prevent cardiomyocyte apoptosis in mice. It is an important way to effectively regulate Bcl-2, Bax expression and Bcl-2/Bax level of cardiomyocytes.
data demonstrate that disruption of the beclin 1-BCL2 complex is an effective mechanism to increase autophagy, prevent premature ageing, improve healthspan and promote longevity in mammals
Results support a link between age-related apoptosis in auditory cortex neurons and miR-34a/Bcl-2 signaling, which may serve as a potential mechanism of the expression of age-related hearing loss in the auditory cortex.
MiR-146a inhibits proliferation and induces apoptosis in murine osteoblastic MC3T3-E1 by regulating Bcl2
The data revealed that autophagy is an important regulator of osteoblastic apoptosis through its interaction with Bax/Bcl2, and maintains the osteoblastic function of MC3T3E1 cells following GC exposure. In addition, these results indicated that the suppression of autophagy in OBs under chronic GC therapy may increase the prevalence of GCinduced osteoporosis and fragility fractures.
Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53/Bax activation.
The results suggest that SPK2 interacts with Bcl2 via its BH3 domain, thereby dissociating it from Beclin-1 and activating autophagy while protecting neurons against ischemic injury.
The findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins, BCL2, Mcl1, and BCL2A1, rather than by a single anti-apoptotic protein.
Bcl-2 is strongly expressed in the inner hair cells and spiral ganglion neurons of young mice. In addition, moderate Bcl-2 expression is also detected in the outer hair cells and in the neurons of the auditory cortex. A significant reduction of Bcl-2 expression in the cochlea or auditory cortex is also associated with elevated hearing thresholds and hair cell loss during aging.
Bcl2 is the autophagy-related target of miR-449a.
anti-apoptotic molecules BclxL and Bcl-2 and the pro-apoptotic factors BAD and BID cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L.
Acute ethanol exposure induced autophagy-mediated heart toxicity and injury mainly through the ROS-JNK-Bcl-2 signaling pathway.
Th17 cells are resistant to glucocorticoid-induced apoptosis and cytokine suppression, at least in part due to high levels of BCL-2. These findings support a role of Th17 cells in glucocorticoid-resistant inflammatory conditions such as certain endotypes of asthma.
E2 protects skeletal myoblasts against apoptosis induced by H2 O2 modulating p53 and FoxO transcription factors and then their target genes Bcl-2, Bim, Puma, PERP, and MDM2, without affecting Noxa gene.
Bcl-2 expression has a significant impact on the mineralogical content of enamel crystals of tooth structure
The results suggest that CARP can protect against hypoxia-reperfusion induced cardiomyocyte apoptosis, possibly through increasing anti-apoptosis Bcl2 gene expression.
upregulated in choriodecidua following labor
These results suggest a role for mitochondrial p53 activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax and Bcl2.
Zebrafish gene expressions of P53, Bcl-2, Bax and caspase-3 were elevated after exposure with microcystin-LR under different ambient temperatures.
Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1, and ICAM1 in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.
Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 and bcl2, but increased p53 expression.
Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 and fish bcl-2, indicating synergy between the Notch pathway and the bcl2-mediated antiapoptotic pathway.
Over-expression of STC-1 up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 production in the damaged cells. Findings from this study suggest that STC-1 plays a protective role in intestinal cells through an antioxidant mechanism.
BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax expression.
G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.
role of vascular endothelial growth factor receptor-1 in Bcl-2 expression
apoptosis-inducing factor was expressed in luminal alveolar cells and, in concert with a change in bax protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
mRNA expression of Bax, Bcl-2, caspase-3 and-7 cannot be used as a reliable apoptosis detection method.
These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.
bcl-2 and bax were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax]
excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 expression as well as low Bcl-2 expression.
These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax ratio through a mechanism involving protein kinase C.
Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax and decreasing expression of bcl2.
Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax.
Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 proteins.
Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3.
Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
apoptosis regulator Bcl-2
, protein phosphatase 1, regulatory subunit 50
, B cell lymphoma 2 associated oncogene
, B-cell leukemia/lymphoma 2
, Bcl2-like protein
, BCL2B-cell CLL/lymphoma 2
, B-cell lymphoma protein 2
, B-cell CLL/lymphoma 2
, LOW QUALITY PROTEIN: apoptosis regulator Bcl-2
, Apoptosis regulator Bcl-2