Browse our anti-BCL2 (BCL2) Antibodies

Human B-Cell CLL/lymphoma 2 (BCL2) interaction partners

1. Polo-like kinase (show PLK1 Antibodies) inhibition can sensitize cholangiocarcinoma cells to cisplatin-induced apoptosis with proteasomal Bcl-2 degradation as an additional pro-apoptotic effect.

2. Lipid oxidation product 4-hydroxy-2-nonenal is at the crossroads of NF-kappaB (show NFKB1 Antibodies) pathway and anti-apoptotic Bcl2 expression. (Review)

3. Ibrutinib-resistant TMD8 cells had higher BCL2 gene expression and increased sensitivity to ABT-199, a BCL-2 inhibitor. Consistently, clinical samples from ABC (show ABCB6 Antibodies)-DLBCL patients who experienced poorer response to ibrutinib had higher BCL2 gene expression. We further demonstrated synergistic growth suppression by ibrutinib and ABT-199 in multiple ABC (show ABCB6 Antibodies)-DLBCL, GCB (show GBA Antibodies)-DLBCL, and follicular lymphoma cell lines.

4. MUC1 (show MUC1 Antibodies)-C Stabilizes MCL-1 (show MCL1 Antibodies) in the Oxidative Stress Response of Triple-Negative Breast Cancer Cells to BCL-2 Inhibitors

5. The BCL2 c.-938C>A and c.21G>A single-nucleotide polymorphisms showed a significant impact on outcome with transitional cell carcinoma of the bladder

6. High expression of prosurvival BCL2 proteins and inhibition of apoptosis and autophagy prolongs Sertoli survival upon exposure to stress stimuli.

7. on the basis of data obtained during the study, it can be concluded that these polyphenols have the potential to be used as lead molecules for BCL-2 inhibition.

8. Tumor cell hypoxia induced Bcl-2/Twist1 (show TWIST1 Antibodies) complex formation, promoting tumor cell invasion in oral squamous cell carcinoma.

9. Bcl-2 rs1800477A/G polymorphism may be related to the occurrence of colorectal cancer(CRC (show CALR Antibodies)), and GG genotype could be a risk factor of poor prognosis in CRC (show CALR Antibodies).

10. BTK (show BTK Antibodies)-mediated signaling was found to be highly attenuated accompanied by a shift in PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and apoptosis regulation-associated genes/proteins. Cytotoxicity studies using the AKT (show AKT1 Antibodies) inhibitor, MK2206+/-ibrutinib, and the Bcl-2-specific inhibitor, venetoclax+/-ibrutinib, demonstrated synergistic loss of cell viability

Mouse (Murine) B-Cell CLL/lymphoma 2 (BCL2) interaction partners

1. The results suggest that SPK2 (show SPHK2 Antibodies) interacts with Bcl2 via its BH3 domain, thereby dissociating it from Beclin-1 (show BECN1 Antibodies) and activating autophagy while protecting neurons against ischemic injury.

2. The findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins, BCL2, Mcl1 (show MCL1 Antibodies), and BCL2A1 (show BCL2A1 Antibodies), rather than by a single anti-apoptotic protein.

3. Bcl-2 is strongly expressed in the inner hair cells and spiral ganglion neurons of young mice. In addition, moderate Bcl-2 expression is also detected in the outer hair cells and in the neurons of the auditory cortex. A significant reduction of Bcl-2 expression in the cochlea or auditory cortex is also associated with elevated hearing thresholds and hair cell loss during aging.

4. Bcl2 is the autophagy-related target of miR (show MLXIP Antibodies)-449a.

5. anti-apoptotic molecules BclxL (show BCL2L1 Antibodies) and Bcl-2 and the pro-apoptotic factors BAD and BID (show BID Antibodies) cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L (show FASL Antibodies).

6. Acute ethanol exposure induced autophagy-mediated heart toxicity and injury mainly through the ROS (show ROS1 Antibodies)-JNK (show MAPK8 Antibodies)-Bcl-2 signaling pathway.

7. Th17 cells are resistant to glucocorticoid-induced apoptosis and cytokine suppression, at least in part due to high levels of BCL-2. These findings support a role of Th17 cells in glucocorticoid-resistant inflammatory conditions such as certain endotypes of asthma.

8. E2 protects skeletal myoblasts against apoptosis induced by H2 O2 modulating p53 (show TP53 Antibodies) and FoxO (show FOXO3 Antibodies) transcription factors and then their target genes Bcl-2, Bim (show BCL2L11 Antibodies), Puma (show BBC3 Antibodies), PERP (show PERP Antibodies), and MDM2 (show MDM2 Antibodies), without affecting Noxa (show PMAIP1 Antibodies) gene.

9. Bcl-2 expression has a significant impact on the mineralogical content of enamel crystals of tooth structure

10. The results suggest that CARP (show ANKRD1 Antibodies) can protect against hypoxia-reperfusion induced cardiomyocyte apoptosis, possibly through increasing anti-apoptosis Bcl2 gene expression.

Zebrafish B-Cell CLL/lymphoma 2 (BCL2) interaction partners

1. These results suggest a role for mitochondrial p53 (show TP53 Antibodies) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax (show BAX Antibodies) and Bcl2.

2. Zebrafish gene expressions of P53 (show TP53 Antibodies), Bcl-2, Bax (show BAX Antibodies) and caspase-3 (show CASP3 Antibodies) were elevated after exposure with microcystin-LR under different ambient temperatures.

3. Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1 (show S1PR1 Antibodies), and ICAM1 (show ICAM1 Antibodies) in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.

4. Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 (show COX2 Antibodies) and bcl2, but increased p53 (show TP53 Antibodies) expression.

5. Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 (show NOTCH1 Antibodies) and fish bcl-2, indicating synergy between the Notch (show NOTCH1 Antibodies) pathway and the bcl2-mediated antiapoptotic pathway.

Cow (Bovine) B-Cell CLL/lymphoma 2 (BCL2) interaction partners

1. Over-expression of STC-1 (show STC1 Antibodies) up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 (show CASP3 Antibodies) production in the damaged cells. Findings from this study suggest that STC-1 (show STC1 Antibodies) plays a protective role in intestinal cells through an antioxidant mechanism.

2. BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax (show BAX Antibodies) expression.

3. G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.

4. role of vascular endothelial growth factor receptor-1 (show FLT1 Antibodies) in Bcl-2 expression

5. apoptosis-inducing factor (show AIFM1 Antibodies) was expressed in luminal alveolar cells and, in concert with a change in bax (show BAX Antibodies) protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses

6. mRNA expression of Bax (show BAX Antibodies), Bcl-2, caspase-3 (show CASP3 Antibodies) and-7 cannot be used as a reliable apoptosis detection method.

7. These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.

Guinea Pig B-Cell CLL/lymphoma 2 (BCL2) interaction partners

1. bcl-2 and bax (show BAX Antibodies) were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax (show BAX Antibodies)]

Rabbit B-Cell CLL/lymphoma 2 (BCL2) interaction partners

1. excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 (show CASP3 Antibodies) expression as well as low Bcl-2 expression.

2. These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax (show BAX Antibodies) ratio through a mechanism involving protein kinase C (show PKC Antibodies).

3. Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax (show BAX Antibodies) and decreasing expression of bcl2.

4. Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax (show BAX Antibodies).

5. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 (show TP53 Antibodies) and decrease in the antiapoptotic BCl2 proteins.

6. Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3 (show CASP3 Antibodies).

7. Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.