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Human Cortactin Protein expressed in HEK-293 Cells - ABIN2712518
Labrador-Horrillo, Martínez, Selva-OCallaghan, Trallero-Araguás, Grau-Junyent, Vilardell-Tarrés, Juarez: Identification of a novel myositis-associated antibody directed against cortactin. in Autoimmunity reviews 2014
Show all 3 Pubmed References
Data show that cortactin-mediated p21Cip1 (show CDKN1A Proteins) nuclear export and degradation facilitating MCP1 (show CCL2 Proteins)-induced human aortic smooth muscle cell (HASMC) proliferation.
Mena (show EGFR Proteins)(INV (show INVS Proteins)) promotes invadopodium maturation by inhibiting normal dephosphorylation of cortactin at tyrosine 421 by the phosphatase PTP1B (show PTPN1 Proteins).
CTTN expression increases EGFR (show EGFR Proteins) protein levels and enhances the activation of the MAPK (show MAPK1 Proteins) signaling pathway. CTTN expression also inhibits the ubiquitin-mediated degradation of EGFR (show EGFR Proteins) by suppressing the coupling of c-Cbl (show CBL Proteins) with EGFR (show EGFR Proteins).
the study revealed that PTBP1 (show PTBP1 Proteins) facilitates colorectal cancer migration and invasion activities by inclusion of cortactin exon 11
Overall, the authors find that p27 (show PAK2 Proteins) directly promotes cell invasion by facilitating invadopodia turnover via the Rac1/PAK1 (show PAK1 Proteins)/Cortactin pathway.
Tyrosine dephosphorylation of the cytoskeletal scaffold, cortactin, recruits the RhoA (show RHOA Proteins) antagonist SRGAP1 (show SRGAP1 Proteins) to relax adherens junctions in response to HGF (show HGF Proteins).
cortactin binds to E-cadherin (show CDH1 Proteins), and that a posttranslational modification of cortactin, RhoA (show RHOA Proteins)-induced phosphorylation by protein kinase D1 (PKD1; also known as PRKD1 (show PRKD1 Proteins)) at S298, impairs adherens junction assembly and supports their dissolution.
Unique role for PBF (show PTTG1IP Proteins) in regulating CTTN function to promote endocrine cell invasion and migration.
AMPK (show PRKAA1 Proteins) phosphorylation of cortactin followed by SIRT1 (show SIRT1 Proteins) deacetylation modulates the interaction of cortactin and cortical-actin in response to shear stress. Functionally, this AMPK (show PRKAA1 Proteins)/SIRT1 (show SIRT1 Proteins) coregulated cortactin-F-actin dynamics is required for endothelial nitric oxide synthase (show NOS3 Proteins) subcellular translocation/activation and is atheroprotective.
These data suggest a model in which cortactin promotes exosome secretion by stabilizing cortical actin-rich multivesicular late endosome docking sites.
These findings suggest that the patterning of podosomes into a sealing zone involves the dynamic interaction between cofilin (show CFL1 Proteins), CTTN, and the microtubule + ends.
Cortactin may have an important role in the development of oral tumors in mice
findings reveal that Keap1 (show KEAP1 Proteins) regulates cell migration by affecting the subcellular localization and activity of cortactin independently of its role in oxidant stress responses.
association of cortactin with Pfn-1 (show PFN1 Proteins) is regulated by c-Abl (show ABL1 Proteins)-mediated cortactin phosphorylation
Cell proliferation, migration and invasion were inhibited by genetic knockdown of EMS1.
our findings suggest that after GnRHa activation, src activity leads to tyrosine phosphorylation of cortactin, which facilitates its association with Arp3 to engage the actin cytoskeleton.
GIT1-cortactin association through GIT1-Spa (show FASL Proteins) homology domain is required for cortactin localization to the leading edge and is essential for endothelial cell directional migration and tumor angiogenesis.
Data indicate that cortactin as an Src (show SRC Proteins)-dependent interacting partner of EB1 (show MAPRE1 Proteins).
Introduction of three 4-R-hydroxyproline residues stabilizes the SH3m-cortactin binding of HPK1 (show MAP4K1 Proteins) peptide.
our data suggest that cortactin and Arp2/3 mediated actin polymerization is implicated in the cell movement during gastrulation and perhaps the development of the central neural system as well.
These findings suggest that this common cortactin variant may functionally contribute to ALI predisposition by impeding endothelial wound healing.
Demonstrate a novel regulation and role for cortactin in FVIIa/TF-mediated endothelial cell migration that occurs through a PAR2 (show F2RL1 Proteins) and RhoA (show RHOA Proteins) dependent mechanism.
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
, ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
, oncogene EMS1
, src substrate cortactin
, mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)
, cortactin isoform B
, src substrate protein p85
, Src substrate cortactin
, src substrate cortactin-like