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Human Cortactin Protein expressed in HEK-293 Cells - ABIN2712518
Labrador-Horrillo, Martínez, Selva-OCallaghan, Trallero-Araguás, Grau-Junyent, Vilardell-Tarrés, Juarez: Identification of a novel myositis-associated antibody directed against cortactin. in Autoimmunity reviews 2014
Show all 3 Pubmed References
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
, ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
, oncogene EMS1
, src substrate cortactin
, mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)
, cortactin isoform B
, src substrate protein p85
, Src substrate cortactin
, src substrate cortactin-like