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Human ERK2 Protein expressed in Wheat germ - ABIN1310256
Abeydeera, Egli, Cox, Mercier, Conde, Pallan, Mizurini, Sierant, Hibti, Hassell, Wang, Liu, Liu, Martinez, Sood, Lybrand, Frydman, Monteiro, Gomer, Nawrot, Yang: Evoking picomolar binding in RNA by a single phosphorodithioate linkage. in Nucleic acids research 2016
Human ERK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2001936
Slack, Seternes, Gabrielsen, Keyse: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. in The Journal of biological chemistry 2001
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thrombin (show F2 Proteins) binding to PAR-1 (show MARK2 Proteins) receptor activated Gi-protein/c (show PROC Proteins)-Src (show SRC Proteins)/Pyk2 (show PTK2B Proteins)/EGFR (show EGFR Proteins)/PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/p42/p44 (show PSMC6 Proteins) MAPK (show MAPK3 Proteins) cascade, which in turn elicited AP-1 (show FOSB Proteins) activation and ultimately evoked MMP-9 (show MMP9 Proteins) expression and cell migration in SK-N-SH cells.
These results indicate that not H1 but M3 receptor-induced activation of p38 MAPK (show MAPK14 Proteins) might contribute to the maintenance of epithelial barrier function through down-regulation of TNF-alpha (show TNF Proteins) signalling and activation of EGFR (show EGFR Proteins).
Our findings suggest that p-MAPK1 (show MAPK3 Proteins) expression could identify a poor prognostic subgroup of AITL patients who could benefit from RAS/RAF (show RAF1 Proteins)/MEK (show MAP2K1 Proteins)/MAPK1 (show MAPK3 Proteins) pathway inhibitors or from other specific chemotherapeutic regimens.
reactivation of ERK (show EPHB2 Proteins) and Akt (show AKT1 Proteins) associated respectively with the activity of mutant BRAF (show BRAF Proteins) and CDC37 (show CDC37 Proteins) renders mutant BRAF (show BRAF Proteins) colon cancer cells resistant to AUY922
Is p38 MAPK (show MAPK14 Proteins) a Dark Force in Right Ventricular Hypertrophy and Failure in Pulmonary Arterial Hypertension.
Nestin (show NES Proteins) promotesneural progenitor cells (NPCs) proliferation via p38-MAPK (show MAPK14 Proteins) and EGFR (show EGFR Proteins) pathways, and reveals the necessity of these pathways in NPCs self-renewal.
Taken together, we suggest that AGEs directly promote primary breast cancer cells via the ERK (show EPHB2 Proteins) and NF-kappaB (show NFKB1 Proteins) pathway, which may lead to advanced therapeutic modalities of breast cancer.
Fas-FasL is the preferred death pathway for both Th1 and Th17 and that inherently low Erk2 activity protected Th17 cells from TCR AICD.
This study supports a role of the MAPK1 (show MAPK3 Proteins) gene in the biological networks related to Bipolar Disorder.
Apocynin may act as a novel molecular candidate to protect against vascular smooth muscle cell osteogenic switching/vascular calcification through suppressing ERK1/2 pathway.
Betacellulin (show BTC Proteins) promotes the proliferation of corneal epithelial stem cells through the phosphorylation of Erk1 (show MAPK3 Proteins)/Erk2.
A stimulation induced PARP1 (show PARP1 Proteins) binding to phosphorylated Erk2 in the chromatin of cerebral neurons caused Erk (show EPHB2 Proteins)-induced PARP1 (show PARP1 Proteins) activation, rendering transcription factors and promoters of immediate early (show JUN Proteins) genes (IEG) accessible to PARP1 (show PARP1 Proteins)-bound phosphorylated Erk2.
Collectively, this study firstly demonstrated that PRMT1 (show PRMT1 Proteins) exert podocyte-injury effects in mouse glomerulus through Ang (show ANG Proteins) /ERK (show EPHB2 Proteins) pathway, which reveals a potential therapeutic target for DN.
North American ginseng inhibits myocardial NOX2 (show CYBB Proteins)-ERK1/2-TNF-alpha (show TNF Proteins) signaling pathway and improves cardiac function in endotoxemia, suggesting that NA ginseng may have the potential in the prevention of clinical sepsis.
NF-alpha1 is critical for regulating antiproliferation and cell fate determination, through differentiating embryonic stem cells to GFAP (show GFAP Proteins)-positive astrocytes for normal neurodevelopment.
These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.
these findings suggest an important role of GPR160 (show GPR160 Proteins) in regulating the entry of BCG (show SLC11A1 Proteins) into macrophages by targeting the ERK (show EPHB2 Proteins) signaling pathway.
Cortical neuron-specific deletion of extracellular signal-regulated kinases Erk1 (show MAPK3 Proteins) or Erk2 significantly increased the duration of wakefulness.
pERK1/2 is a regulator of CD44 (show CD44 Proteins) expression, and increased CD44 (show CD44 Proteins) expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
mmLDL increased the serum concentrations and expression of ICAM-1 (show ICAM1 Proteins) and VCAM-1 (show VCAM1 Proteins) by activating the ERK1/2 pathway, resulting in the expression of ETB (show EDNRB Proteins) receptors and the enhancement of contractile function in vascular smooth muscle.
The present results suggest that demecolcine might contribute to the activation of the Mos (show MOCOS Proteins)/MAPK pathway and affect spindle structure
MAPK1 upregulated milk protein (show CSN2 Proteins) synthesis through the Stat5 (show STAT5A Proteins) and mTOR (show FRAP1 Proteins) pathways.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Cyclin-dependent kinase (show CDK1 Proteins) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (show MSLN Proteins)) and MAPK, and had nearly no effect on kinase activities during maturation.
Thrombospondin 1 (show THBS1 Proteins), fibronectin (show FN1 Proteins), and vitronectin (show VTN Proteins) are differentially dependent upon RAS, ERK1/2, and p38 (show MAPK14 Proteins) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (show EGR1 Proteins) nuclear accumulation.
Role of CaMKII (show CAMK2G Proteins) in hydrogen peroxide activation of p38 MAPK (show MAPK14 Proteins)/heat shock protein 27 pathway and ERK1/2
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
Excess PLAC8 promotes an unconventional ERK2-dependent EMT (show ITK Proteins) in colon cancer.
ERK1/2-Akt1 (show AKT1 Proteins) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (show SH3GL1 Proteins) plays an important role in the development of the myeloid cell through activation of the ERK1 (show MAPK3 Proteins)/ERK2 pathway
ERK1 (show MAPK3 Proteins) and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK2 genes involved in cell-migration, mesendoderm differentiation and patterning were identified.
These results demonstrate that induction of Hsp70 (show HSPA1A Proteins) in response to heat stress is dependent on ERK activation in Pac2 (show PSMG2 Proteins) cells.
Data define distinct roles for ERK1 (show MAPK3 Proteins) and ERK2 in developmental cell migration processes during zebrafish embryogenesis.
Here the authors show that CPEB4 activity is regulated by ERK2- and Cdk1-mediated hyperphosphorylation. These phosphorylation events additively activate CPEB4 in M-phase by maintaining it in its monomeric state.
The reciprocal feedback observed between MPF (show MSLN Proteins) and ERK2 in meiosis is not observed during mitotic M-phase in cell-free Xenopus embryo extracts.
MKP1 (show DUSP1 Proteins) is a negative regulator of signaling pathways required for some, but not all, early and late pathogen-associated molecular pattern responses.
MKP1 (show DUSP1 Proteins) and PTP1 act redundantly to suppress salicylic acid and camalexin biosynthesis, and regulate growth homeostasis and PR gene expression in an MPK3 (show MAPK3 Proteins)- and MPK6 (show MAPK6 Proteins)-dependent manner.
Regulation of AtMPK1/2 kinase activity in Arabidopsis might be under the control of signals involved in different kinds of stress.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Agonist stimulation of vascular smooth muscle increases PKC (show FYN Proteins) activity, which, in turn, increases MKP-1 (show DUSP1 Proteins) activity and maintains MAPK1 activity at submaximal values.
sub-vasomotor concentration of ET-1 (show EDN1 Proteins) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Proteins) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Proteins) following ETA receptor activation
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (show CSF2 Proteins) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK-dependent MTOR (show FRAP1 Proteins) signal transduction cascades.
PGRN (show GRN Proteins) inhibits adipogenesis in porcine preadipocytes partially through ERK activation mediated PPARgamma (show PPARG Proteins) phosphorylation.
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (show MAPK8 Proteins)/2 dependent.
The authors show that porcine circovirus type 2 (PCV2) activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication.
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
, MAP kinase 1
, MAP kinase 2
, MAP kinase isoform p42
, MAPK 2
, extracellular signal-regulated kinase 2
, mitogen-activated protein kinase 2
, protein tyrosine kinase ERK2
, MAPK 1
, mitogen activated protein kinase 1
, extracellular-signal-regulated kinase 2
, mitogen-activated protein kinase 1
, MAP kinase
, mitogen-activated protein kinase 1b
, myelin basic protein kinase-like protein
, mitogen-activated protein kinase 1a
, extracellular signal-regulated kinase-2
, extracellular regulated protein 2