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Androgen-induced miR (show MLXIP Proteins)-27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression
the expression level of MAP2K4 was inversely associated with the expression of miR (show MLXIP Proteins)-802 in tongue squamous cell carcinoma (TSCC) tissues; demonstration that the MAP2K4 expression was upregulated in TSCC cell lines; elevated expression of miR (show MLXIP Proteins)-802 inhibited TSCC cell viability and invasion through inhibiting MAP2K4 expression
MKK4 activates non-canonical NFkappaB (show NFKB1 Proteins) signaling by promoting NFkappaB2-p100 (show CUX1 Proteins) processing.
Manipulating the expression of both miR (show MLXIP Proteins)-222 and miR (show MLXIP Proteins)-25 influenced diverse gene expression changes in thyroid cells. Increased expression of miR (show MLXIP Proteins)-25 reduced MEK4 and TRAIL protein expression, and cell adhesion and apoptosis are important aspects of miR (show MLXIP Proteins)-25 functioning in thyroid cells.
These results suggest that ROCK may be important in IL-1 (show IL1A Proteins)-induced signaling through MKK4 to JNK (show MAPK8 Proteins) and the activation of p38 MAPK (show MAPK14 Proteins).
Association between MKK4 promoter polymorphism and breast cancer risk in Kashmiri population
In Chinese Han ischemic stroke patients rs3826392 C/A genotype carriers showed significantly higher IL-1b (show IL1B Proteins) serum levels.
The plasma level of protein MAP2K4 was found to suggestively associate negatively with the volume of the left entorhinal cortex in asymptomatic older twins.
MAP2K4 increases human prostate cancer metastasis, and prolonged over expression induces long term changes in cell signaling pathways leading to independence from p38 MAPK (show MAPK14 Proteins) and JNK (show MAPK8 Proteins).
MKK4 is activated in vitro by reduced Trx (show VAC14 Proteins) but not oxidized Trx (show VAC14 Proteins) in the absence of an upstream kinase, suggesting that autophosphorylation of this protein occurs due to reduction of Cys (show DNAJC5 Proteins)-246 and Cys (show DNAJC5 Proteins)-266 by Trx (show VAC14 Proteins).
MKK4 activates non-canonical NFkappaB signaling by promoting NFkappaB2-p100 (show PATL2 Proteins) processing.
Demonstrate that Mkk4 is a negative regulator of the TGF-beta1 (show TGFB1 Proteins) signaling associated with atrial remodeling and arrhythmogenesis with age.
This study provides compelling evidence for the pivotal roles of the ZPK/DLK (show MAP3K12 Proteins) and MKK4/MAP2K4-dependent mechanism in axotomy-induced motoneuron death in neonates.
The loss of mkk4 and mkk7 (show MAP2K7 Proteins) locks damaged exocrine cells in a permanently de-differentiated state.
Studies identify the dual-specific kinase MKK4 as a master regulator of liver regeneration. MKK4 silencing robustly increased the regenerative capacity of hepatocytes in mouse models of liver regeneration and acute and chronic liver failure.
MicroRNA-92a negatively regulates Toll (show TLR4 Proteins)-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase
Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.
MKK4/7 and JNK1 (show MAPK8 Proteins)/2 played regulatory role in cytoskeleton reorganization during vaccinia virus infection.
These data support a model in which MKK4 activation at the metastatic site causes a cell-cycle arrest.
Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 (show GJA1 Proteins) reduction and couples hypertrophic signals to ventricular arrhythmogenesis.
in Drosophila both MAPKKs, Hep/Mkk7 (show MAP2K7 Proteins) and Mkk4, are required to induce JNK (show MAPK8 Proteins) upon TNF (show TNF Proteins) or pro-inflammatory stimulation
MKK4, MKK5 (show MAP2K5 Proteins), MKK7 (show MAP2K7 Proteins), and MKK9, are responsible for the activation of MPK3 (show MAPK3 Proteins) and MPK6 (show MAPK6 Proteins) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (show MAPK1 Proteins) signaling through MKK4/5/7/9-MPK3 (show MAPK3 Proteins)/6 cascades.
our data indicate that EDR1 physically associates with MKK4/MKK5 (show MAP2K5 Proteins) and negatively regulates the MAPK (show MAPK1 Proteins) cascade to fine-tune plant innate immunity.
Results suggest that the YDA-MKK4/MKK5 (show MAP2K5 Proteins)-MPK3 (show MAPK3 Proteins)/MPK6 (show MAPK6 Proteins) cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.
MKK4 is involved in the osmotic-stress response via its regulation of MPK3 (show MAPK3 Proteins) activity.
MKK4 is a key regulator of stomatal development and patterning.
This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
JNK activating kinase 1
, JNK-activated kinase 1
, JNK-activating kinase 1
, MAP kinase kinase 4
, MAPK/ERK kinase 4
, MAPKK 4
, MEK 4
, SAPK/ERK kinase 1
, c-Jun N-terminal kinase kinase 1
, dual specificity mitogen-activated protein kinase kinase 4
, stress-activated protein kinase kinase 1
, C-JUN N-terminal kinase kinase 1
, JNK kinase 1
, JNKK 1
, SAPK/Erk/kinase 1
, mitogen activated protein kinase kinase 4, variant 1
, mitogen-activated protein kinase kinase 4
, JNK kinase 2
, Map kinase kinase 4
, drosophila MAP kinase kinase 4